tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Struktur
203661-69-2
CAS-Nr.
203661-69-2
Englisch Name:
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
Synonyma:
2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;ate tert-butyL;7-Boc-2-oxo-7-azaspiro[3....;7-Boc-2-oxo-7-azaspiro[3.5]nonane;N-Boc-2-oxo-7-azaspiro[3.5]nonane;2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL;7-Azaspiro[3.5]nonan-2-one, N-BOC protected;7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one;ert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate;tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
CBNumber:
CB92537657
Summenformel:
C13H21NO3
Molgewicht:
239.31
MOL-Datei:
203661-69-2.mol

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Eigenschaften

Schmelzpunkt:
55-56℃
Siedepunkt:
349℃
Dichte
1.12
Flammpunkt:
165℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
solid
pka
-0.80±0.20(Predicted)
Farbe
Clear yellow
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 36/37/38
S-Sätze: 26-36
HS Code  29339900
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White powder

Synthese

To a flame-dried RB flask with tert-butyl 4-methylenepiperidine-1- carboxylate (2.96 g, 15 mmol, 1.0 equiv) and Zn/Cu couple (6.54 g, 172.5 mmol, 11.5 equiv) under vacuum, t-BuOMe (60 mL) was charged and refilled the flask with N2 balloon. To the mixture thus obtained stirred at 15 °C, a solution of 2,2,2- trichloroacetyl chloride in DME (20 mL) was added dropwise. The mixture was stirred at room temperature overnight after addition. To the reaction mixture stirred in an external ice- bath, a saturated solution of NH4CI (60 mL) was added slowly and carefully (especially the first few drops). After addition, the mixture was stirred at room temperature for 4 h and filtered to remove the solid. The phases were separated. The aqueous phase was extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2S04, and concentrated to give the residue, which was purified by CombiFlash (40 g silica gel column, EtOAc/Hexane: 0-40percent) to afford 619 mg (15%) of tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate.

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • 7-Boc-2-oxo-7-azaspiro[3....
  • 7-Boc-2-oxo-7-azaspiro[3.5]nonane
  • tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
  • 7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one
  • 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester
  • 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester
  • 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
  • 7-Azaspiro[3.5]nonan-2-one, N-BOC protected
  • N-Boc-2-oxo-7-azaspiro[3.5]nonane
  • ert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
  • 2-Oxo-7-aza-spiro3.5none-7-carboxylic acid tert-butyl ester
  • 2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL
  • ate tert-butyL
  • 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester
  • 1,1-Dimethylethyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
  • 2-oxo-7-azaspiro[3,5]nonane-7-carboxylic tertbytyl ester
  • 203661-69-2
  • 6203661-69-2
  • 03661-69-2
  • 203661-89-2
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