Procain

Procaine Struktur
59-46-1
CAS-Nr.
59-46-1
Bezeichnung:
Procain
Englisch Name:
Procaine
Synonyma:
P;Novocaine;Novocain;2-(Diethylamino)ethyl 4-aminobenzoate;Procine;Procain;Procaine powder;Procaine hydrochlori;4-amino-benzoicaci2-(diethylamino)ethylester;Jenacain
CBNumber:
CB9296712
Summenformel:
C13H20N2O2
Molgewicht:
236.31
MOL-Datei:
59-46-1.mol

Procain Eigenschaften

Schmelzpunkt:
61°
Siedepunkt:
378.78°C (rough estimate)
Dichte
1.0604 (rough estimate)
Brechungsindex
1.5430 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
pKa 9.04±0.01(H2O,t=25,I=0.1(NaCl))(Approximate)
Farbe
White to Off-White
Wasserlöslichkeit
9.45g/L(30 ºC)
Merck 
14,7757
Stabilität:
Hygroscopic
InChI
InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
InChIKey
MFDFERRIHVXMIY-UHFFFAOYSA-N
SMILES
C(OCCN(CC)CC)(=O)C1=CC=C(N)C=C1
CAS Datenbank
59-46-1(CAS DataBase Reference)
NIST chemische Informationen
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester(59-46-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  3249
RTECS-Nr. DG2100000
HS Code  2922.49.3700
HazardClass  6.1(b)
PackingGroup  III
Giftige Stoffe Daten 59-46-1(Hazardous Substances Data)
Toxizität LD50 in mice (mg/kg): 195 i.p.; 45 i.v. (North, Urbach)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Procain Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Procaine is a local anesthetic with a para-amino function. Sensitization mainly concerns medical, dental and veterinary professions.

Chemische Eigenschaften

The hydrochloride salt of 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 or N2C6H4COOCH2CH2NH(C2H5)2HCl) is generally referred to as procaine. Although the PABA ester is insoluble in water, the hydrochloride salt is very soluble in water.

Verwenden

Procaine (Novocain) is mainly used in dental or medical procedures requiring infiltration anesthesia, peripheral block, or spinal block.

Definition

ChEBI:Procaine is a benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. It has a role as a local anaesthetic, a central nervous system depressant, a peripheral nervous system drug and a drug allergen. It is a benzoate ester, a substituted aniline and a tertiary amino compound. It is functionally related to a 2-diethylaminoethanol and a 4-aminobenzoic acid. It is a conjugate base of a procaine(1+).

Biologische Funktion

Procaine hydrochloride (Novocain) is readily hydrolyzed by plasma cholinesterase, although hepatic metabolism also occurs. It is not effective topically but is employed for infiltration, nerve block, and spinal anesthesia. It has a relatively slow onset and short (1 hour) duration of action. All concentrations can be combined with epinephrine. It is available in dental cartridges with phenylephrine as the vasoconstrictor.

Allgemeine Beschreibung

Procaine was synthesized in 1904 to address the chemical instabilityof cocaine and the local irritation it produced. The pKa of procaine is 8.9; it has low lipid solubility and the estergroup is unstable in basic solutions. Procaine is available inconcentrations ranging from 0.25% to 10% with pHs adjustedto 5.5 to 6.0 for chemical stability. Procaine is also includedin some formulations of penicillin G to decrease the pain ofintramuscular injection.

Kontakt-Allergie

Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.

Mechanism of action

The fundamental mechanism of analgesia underlying all local anesthetics is the blockade of neurotransmission via inhibition of sodium channels along nerve fibers. Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited.

Clinical Use

Procaine is very quickly metabolizedin the plasma by cholinesterases and in the liver via ester hydrolysisby a pseudocholinesterase. The in vitroelimination half-life is approximately 60 seconds. Any conditionthat decreases the cholinesterase concentration may increaseexposure to procaine and potential toxicity. Decreasedenzyme activity can be found with genetic deficiency, liverdisease, malignancy, malnutrition, renal failure, burns, thirdtrimester of pregnancy, and following cardiopulmonary bypasssurgery. Ester hydrolysis produces PABA, the compoundresponsible for the allergic reactions common to theester anesthetics. Procaine is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for cutaneous or mucous membranes, forshort procedures. Procaine is also used for peripheral nerveblock and as an epidural agent to diagnose pain syndromes.

läuterung methode

Procain crystallises as the dihydrate from aqueous EtOH and as the anhydrous material from pet ether or diethyl ether. The latter is hygroscopic. [Beilstein 14 IV 1138.]

Procain Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Procain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 295)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 491 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12446 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2534 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5873 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 853 58
Shandong Hanjiang Chemical Co., Ltd
+86-0533-2066820 +8618369939125
hanson@sdhanjiang.com China 1000 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504 +86-17332992504
sales8@hbganmiao.com China 300 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5866 58
Nanjing Deda New Material Technology Co., Ltd
+8613223293093
bella@njdeda.com China 80 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3138 58

59-46-1(Procain)Verwandte Suche:


  • 2-(Diethylamino)ethyl p-aminobenzoate
  • 2-(diethylamino)ethylp-aminobenzoate
  • 2-diethylaminoethyl4-aminobenzoate
  • 2-Diethylaminoethylester kyseliny p-aminobenzoove
  • 2-diethylaminoethylesterkyselinyp-aminobenzoove
  • 2-diethylaminoethylp-aminobenzoate
  • 4-Aminobenzoic acid diethylaminoethyl ester
  • 4-aminobenzoicaciddiethylaminoethylester
  • Allocaine
  • Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
  • Benzoicacid,4-amino-2-(diethylamino)ethylester
  • beta-(Diethylamino)ethyl 4-aminobenzoate
  • beta-(Diethylamino)ethyl p-aminobenzoate
  • beta-(diethylamino)ethylp-aminobenzoate
  • beta-diethylaminoethyl4-aminobenzoate
  • Diethylaminoethyl p-aminobenzoate
  • diethylaminoethylp-aminobenzoate
  • Duracaine
  • Gerovital
  • Gerovital H-3
  • Jenacain
  • Jenacaine
  • Neocaine
  • Nissocaine
  • Norocaine
  • p-Aminobenzoic acid, 2-(diethylamino)ethyl ester
  • p-amino-benzoicaci2-(diethylamino)ethylester
  • p-aminobenzoicacid2-diethylaminoethylester
  • p-Aminobenzoyldiethylaminoethanol
  • procaine,base
  • 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester 2-(Diethylamino)ethyl 4-Aminobenzoate
  • PROCAINE, NOVOCAINE
  • Procaine, >=98.5%
  • Procaine (base and/or unspecified salts)
  • 4-Aminobenzoic acid 2-(diethylamino)ethyl
  • Scurocaine
  • Spinocaine
  • Vitamin H3
  • vitaminh3
  • PROCAINE
  • 4-AMINO-BENZOIC ACID 2-DIETHYLAMINO-ETHYL ESTER
  • AKOS B006598
  • ART-CHEM-BB B006598
  • PROCAINE HCL, PHARMA GRADE
  • 2-(DIETHYLAMINO)ETHYLPARA-AMINOBENZOICACID
  • PARA-AMINOBENZOICACIDDIETHYLAMINOETHYLESTER
  • PROCAINE(Cas number:59-46-1)
  • Procaine Powder CAS 59-46-1 Procaine kf-wang(at)kf-chem.com
  • procaine base/procaine hcl
  • Procaine>
  • Procaine Lidocaine Tetracaine
  • PROCAINE/CARBOMER 940
  • Procaine powder on sale
  • procaine on sale
  • Procaine Wickr jane8886
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  • PROCAINE USP/EP/BP
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