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プロカイン

プロカイン 化学構造式
59-46-1
CAS番号.
59-46-1
化学名:
プロカイン
别名:
p-アミノ安息香酸2-(ジエチルアミノ)エチル;ニッソカイン;p-アミノ安息香酸ジエチルアミノエチル;プロカインベース;4-アミノ安息香酸2-(ジエチルアミノ)エチル;スピノカイン;プロカイン;p-アミノ安息香酸2-ジエチルアミノエチル;2-(ジメチルアミノ)エチル4-アミノ安息香酸
英語化学名:
PROCAINE
英語别名:
Procain;Procine;Jenacain;Neocaine;Novocain;PROCAINE;Allocaine;Duracaine;Gerovital;Jenacaine
CBNumber:
CB9296712
化学式:
C13H20N2O2
分子量:
236.31
MOL File:
59-46-1.mol

プロカイン 物理性質

融点 :
61°
沸点 :
378.78°C (rough estimate)
比重(密度) :
1.0604 (rough estimate)
屈折率 :
1.5430 (estimate)
貯蔵温度 :
Keep in dark place,Sealed in dry,Room Temperature
酸解離定数(Pka):
pKa 9.04±0.01(H2O,t=25,I=0.1(NaCl))(Approximate)
水溶解度 :
9.45g/L(30 ºC)
Merck :
14,7757
CAS データベース:
59-46-1(CAS DataBase Reference)
NISTの化学物質情報:
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester(59-46-1)

安全性情報

RIDADR  3249
RTECS 番号 DG2100000
国連危険物分類  6.1(b)
容器等級  III
有毒物質データの 59-46-1(Hazardous Substances Data)
毒性 LD50 in mice (mg/kg): 195 i.p.; 45 i.v. (North, Urbach)
化審法 (9)-162

プロカイン 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-7226 プロカイン
Procaine
59-46-1 5g ¥3600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-7226 プロカイン
Procaine
59-46-1 25g ¥10800 2021-03-23 購入
東京化成工業 P1961 プロカイン >98.0%(HPLC)(T)
Procaine >98.0%(HPLC)(T)
59-46-1 5g ¥2800 2021-03-23 購入
東京化成工業 P1961 プロカイン >98.0%(HPLC)(T)
Procaine >98.0%(HPLC)(T)
59-46-1 25g ¥8600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01MAS075800 プロカイン
Procaine
59-46-1 5g ¥4000 2021-03-23 購入

プロカイン 化学特性,用途語,生産方法

外観

白色~ほとんど白色粉末~結晶

解説

2-(diethylamino)ethyl 4-aminobenzoate.C13H20N2O2(236.31).p-アミノ安息香酸エチルと2-ジエチルアミノエタノールとを加熱してエステル交換するか,あるいは,塩化p-ニトロベンゾイルと2-ジエチルアミノエタノールとを反応させ,生成物を還元して製造する.融点61 ℃.水和物の融点51 ℃.エタノール,エーテル,クロロホルム,ベンゼンに可溶.塩酸塩(ノボカイン,融点156 ℃)は局所麻酔薬として用いられる.刺激性はなく,毒性はコカインの1/6~1/10.LD50 340~800 mg/kg(マウス,皮下).[CAS 59-46-1][CAS 51-05-8:塩酸塩]"
森北出版「化学辞典(第2版)

効能

局所麻酔薬

説明

Procaine is a local anesthetic with a para-amino function. Sensitization mainly concerns medical, dental and veterinary professions.

化学的特性

The hydrochloride salt of 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 or N2C6H4COOCH2CH2NH(C2H5)2HCl) is generally referred to as procaine. Although the PABA ester is insoluble in water, the hydrochloride salt is very soluble in water.

使用

Procaine (Novocain) is mainly used in dental or medical procedures requiring infiltration anesthesia, peripheral block, or spinal block.

使用

Procaine is a sodium channel blocker and inhibitor of a variety of processes.

使用

inhibitor of sodium channel

定義

ChEBI: A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

brand name

Novocain (Hospira).

生物学の機能

Procaine hydrochloride (Novocain) is readily hydrolyzed by plasma cholinesterase, although hepatic metabolism also occurs. It is not effective topically but is employed for infiltration, nerve block, and spinal anesthesia. It has a relatively slow onset and short (1 hour) duration of action. All concentrations can be combined with epinephrine. It is available in dental cartridges with phenylephrine as the vasoconstrictor.

一般的な説明

Procaine was synthesized in 1904 to address the chemical instabilityof cocaine and the local irritation it produced. The pKa of procaine is 8.9; it has low lipid solubility and the estergroup is unstable in basic solutions. Procaine is available inconcentrations ranging from 0.25% to 10% with pHs adjustedto 5.5 to 6.0 for chemical stability. Procaine is also includedin some formulations of penicillin G to decrease the pain ofintramuscular injection.

接触アレルゲン

Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.

臨床応用

Procaine is very quickly metabolizedin the plasma by cholinesterases and in the liver via ester hydrolysisby a pseudocholinesterase. The in vitroelimination half-life is approximately 60 seconds. Any conditionthat decreases the cholinesterase concentration may increaseexposure to procaine and potential toxicity. Decreasedenzyme activity can be found with genetic deficiency, liverdisease, malignancy, malnutrition, renal failure, burns, thirdtrimester of pregnancy, and following cardiopulmonary bypasssurgery. Ester hydrolysis produces PABA, the compoundresponsible for the allergic reactions common to theester anesthetics. Procaine is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for cutaneous or mucous membranes, forshort procedures. Procaine is also used for peripheral nerveblock and as an epidural agent to diagnose pain syndromes.

純化方法

Procain crystallises as the dihydrate from aqueous EtOH and as the anhydrous material from pet ether or diethyl ether. The latter is hygroscopic. [Beilstein 14 IV 1138.]

プロカイン 上流と下流の製品情報

原材料

準備製品


プロカイン 生産企業

Global( 229)Suppliers
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59-46-1(プロカイン)キーワード:


  • 59-46-1
  • 2-(Diethylamino)ethyl 4-aminobenzoate
  • 2-(Diethylamino)ethyl p-aminobenzoate
  • 2-(diethylamino)ethylp-aminobenzoate
  • 2-diethylaminoethyl4-aminobenzoate
  • 2-Diethylaminoethylester kyseliny p-aminobenzoove
  • 2-diethylaminoethylesterkyselinyp-aminobenzoove
  • 2-diethylaminoethylp-aminobenzoate
  • 4-Aminobenzoic acid diethylaminoethyl ester
  • 4-amino-benzoicaci2-(diethylamino)ethylester
  • 4-aminobenzoicaciddiethylaminoethylester
  • Allocaine
  • Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
  • Benzoicacid,4-amino-2-(diethylamino)ethylester
  • beta-(Diethylamino)ethyl 4-aminobenzoate
  • beta-(Diethylamino)ethyl p-aminobenzoate
  • beta-(diethylamino)ethylp-aminobenzoate
  • beta-diethylaminoethyl4-aminobenzoate
  • Diethylaminoethyl p-aminobenzoate
  • diethylaminoethylp-aminobenzoate
  • Duracaine
  • Gerovital
  • Gerovital H-3
  • Jenacain
  • Jenacaine
  • Neocaine
  • Nissocaine
  • Norocaine
  • Novocain
  • Novocaine
  • p-Aminobenzoic acid, 2-(diethylamino)ethyl ester
  • p-アミノ安息香酸2-(ジエチルアミノ)エチル
  • ニッソカイン
  • p-アミノ安息香酸ジエチルアミノエチル
  • プロカインベース
  • 4-アミノ安息香酸2-(ジエチルアミノ)エチル
  • スピノカイン
  • プロカイン
  • p-アミノ安息香酸2-ジエチルアミノエチル
  • 2-(ジメチルアミノ)エチル4-アミノ安息香酸
  • 歯科用薬
  • 局所麻酔薬
  • 口腔用薬
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