Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC₅₀ = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC₅₀ = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC₅₀ = 4.2 and ≥0.5 μM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme′s ATP-binding site.

Biochem/physiol Actions

Cell permeable: yes

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

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• Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem
• Methanone, bis(5-hydroxy-1H-indol-2-yl)-
• 896138-40-2