Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

CAS No.
896138-40-2
Chemical Name:
Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem
Synonyms
Methanone, bis(5-hydroxy-1H-indol-2-yl)-;Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem
CBNumber:
CB94813867
Molecular Formula:
C17H12N2O3
Molecular Weight:
292.29
MDL Number:
MFCD24369052
MOL File:
896138-40-2.mol

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Properties

Melting point 215 °C (decomp)(Solv: ethyl ether (60-29-7))
Boiling point 679.4±50.0 °C(Predicted)
Density 1.544±0.06 g/cm3(Predicted)
pka 9.29±0.40(Predicted)

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC50 = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC50 = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC50 = 4.2 and ≥0.5 μM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme′s ATP-binding site.

Biochem/physiol Actions

Cell permeable: yes

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Methanone, bis(5-hydroxy-1H-indol-2-yl)- 896138-40-2