Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem structure

CAS No.: 896138-40-2

Chemical Name:: Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

Synonyms: Methanone, bis(5-hydroxy-1H-indol-2-yl)-;Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

CBNumber:: CB94813867

Molecular Formula:: C17H12N2O3

Molecular Weight:: 292.29

MDL Number:: MFCD24369052

MOL File:: 896138-40-2.mol

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Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Properties

Melting point	215 °C (decomp)(Solv: ethyl ether (60-29-7))
Boiling point	679.4±50.0 °C(Predicted)
Density	1.544±0.06 g/cm3(Predicted)
pka	9.29±0.40(Predicted)

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC₅₀ = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC₅₀ = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC₅₀ = 4.2 and ≥0.5 μM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme′s ATP-binding site.

Biochem/physiol Actions

Cell permeable: yes

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Supplier	Advantage
Sigma-Aldrich	80

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem Methanone, bis(5-hydroxy-1H-indol-2-yl)- 896138-40-2