3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
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- CAS-Nr.
- 86499-96-9
- Englisch Name:
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- Synonyma:
- 3-BroMo-2;IHT-PI BBC;3-Bromo-2,3,4,5-tetr;3-bromobenzocaprolactam;A-BROMOBENZOCAPROLACTAM;α-Bromobenzocaprolactam;ALPHA-BROMOBENZO-CAPROLACTAM;3-Bromo-2,3,4,5-tetrahydro-2H-;3-BromoTetrahydrobenazepin-2-One;5-Trtrahydro-2H-1-benzazepine-2-one
- CBNumber:
- CB9777910
- Summenformel:
- C10H10BrNO
- Molgewicht:
- 240.1
- MOL-Datei:
- 86499-96-9.mol
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Eigenschaften
- Schmelzpunkt:
- 164 °C
- Siedepunkt:
- 383.2±42.0 °C(Predicted)
- Dichte
- 1.492±0.06 g/cm3(Predicted)
- Flammpunkt:
- 185.542℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- slightly soluble in ethanol, benzene, acetone, insoluble in water
- pka
- 13.59±0.40(Predicted)
- CAS Datenbank
- 86499-96-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.
Chemische Eigenschaften
White or almost white crystalline
synthetische
The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
1(2H)-Naphthalenone, 2-bromo-3,4-dihydro-, oxime
2-Bromo-1,2,3,4-tetrahydronaphthalen-1-one
1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one
Benzol
1,2,3,4-Tetrahydro-1-naphthalinon
Downstream Produkte
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 302)Lieferanten
86499-96-9()Verwandte Suche:
- A-BROMOBENZOCAPROLACTAM
- ALPHA-BROMOBENZO-CAPROLACTAM
- 3-Bromobenzocaprolactam 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
- 3-bromobenzocaprolactam
- 3-bromo-1,3,4,5-tetrahdro-2h-benzazepin-2-one
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-L-BENZAZEPIN-2-ONE
- 3-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
- 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2-ONE
- 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- 3-BROMO-2,3,4,5-TETRAHYDRO-2H-BENZO[B]AZEPIN-2-ONE
- 3-BROMO-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENZAZEPINE
- 3-BROMO-2,3,4,5-TRTRAHYDRO-2H-1-BENZAZEPINE-2-ONE
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAEPINE-2-ONE
- 3-BBC: 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE
- 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE
- 3-Bromo-2,3,4,5-tetrahydro-2H-
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE HPLC +99.0%
- 3-BromoTetrahydrobenazepin-2-One
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-BROMO LACTAM)
- α-Bromobenzocaprolactam
- 3-bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
- IHT-PI BBC
- 3-Bromo-2,3,4,5-tetr
- 3-BroMo-2
- 5-Trtrahydro-2H-1-benzazepine-2-one
- 2H-1-Benzazepin-2-one, 3-broMo-1,3,4,5-tetrahydro-
- Intermediate 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-one
- 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one
- 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-on
- 5-tetrahydro-2H-benzo[b]azepin-2-one
- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one >
- 3-Bromo-2,3,4,5-tetrahydro-2-h-1-benzacepin–2one
- 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one USP/EP/BP
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (Benazepril API KSM)
- 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
(Alpha-Bromolactum)
- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzoazo-2-one
- 3-Bromo-1,3,4,5-tetrahydro-2-h-1-benzacepin–2one
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / Benazepril intermediate
- 86499-96-9
- 65-71-6
- 68499-96-9
- 96499-96-9
- C10H10BrNO
- C10H10NOBr
- pharmacetical
- 86499-96-9
- john's
