Amtolmetin guacil
- CAS No.
- 87344-06-7
- Chemical Name:
- Amtolmetin guacil
- Synonyms
- med15;Eufans;ArtroMed;Amtolmetin;AMTOLMETIN GUACIL;AMtolMetin Guacyl;AMTOLMETIO GUACIL;AMtolMethin Guacil;2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate;n-((1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)-glycin2-methoxyphe
- CBNumber:
- CB0129750
- Molecular Formula:
- C24H24N2O5
- Molecular Weight:
- 420.46
- MDL Number:
- MFCD00866153
- MOL File:
- 87344-06-7.mol
| Melting point | 117-120° |
|---|---|
| Boiling point | 663.3±55.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.90±0.46(Predicted) |
| color | Pale Brown to Light Brown |
| CAS DataBase Reference | 87344-06-7(CAS DataBase Reference) |
| FDA UNII | 323A00CRO9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 in male mice, rats (mg/kg): 1370, 1100 i.p.; >1500, 1450 orally (Baglioni) |
Amtolmetin guacil price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A635350 | AmtolmetinGuacil | 87344-06-7 | 100mg | $125 | 2021-12-16 | Buy |
| TRC | A635350 | AmtolmetinGuacil | 87344-06-7 | 1g | $1010 | 2021-12-16 | Buy |
| Usbiological | 485633 | MED15 | 87344-06-7 | 100ul | $499 | 2021-12-16 | Buy |
| Usbiological | 485632 | MED15 | 87344-06-7 | 100ul | $499 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA17894 | Amtolmetin guacil | 87344-06-7 | 50mg | $120.5 | 2021-12-16 | Buy |
Amtolmetin guacil Chemical Properties,Uses,Production
Description
Amtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID) introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain. Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability.
Originator
Sigma Tau (Italy)
Uses
Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,
Definition
ChEBI: Amtolmetin guacil is a N-acyl-amino acid.
brand name
Artromed
Clinical Use
Amtolmetin guacil (AMG) is a non-steroidal anti-inflammatory drug developed by Sigma-Tau for the treatment of pain and inflammation. It acts similarly to tolmetin, and in preclinical trials displayed long-lasting anti-inflammatory and analgesic activity. Amtolmetin has a good gastrointestinal tolerability in humans and does not induce gastric ulcers in the rat . The good gastrointestinal tolerability and even a gastroprotective effect was related to an increase of endogenous NO via stimulation of inducible NO synthase in the gastric mucosa .
Synthesis
The condensation of 1-methyl-
5-(4-methylbenzoyl)pyrrole-2-acetic acid with
glycine ethyl ester in the presence of carbonyldiimidazole
and triethylamine in tetrahydrofuran
gives the corresponding ethyl 2-acetate, which is hydrolyzed with
NaOH in tetrahydrofuran – water yielding 2-
-
acetamido]acetic acid. Finally, this compound is
esterified with 2-methoxyphenol (guaiacol) in
hot tetrahydrofuran with carbonyldiimidazole
as catalyst .
Amtolmetin guacil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
View Lastest Price from Amtolmetin guacil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | Amtolmetin guacil
87344-06-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-25 | Amtolmetin guacil
87344-06-7
|
US $1.00 / KG | 1KG | 85.0-99.8% | 20 tons | Career Henan Chemical Co |
-
- Amtolmetin guacil
87344-06-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Amtolmetin guacil
87344-06-7
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co