Fosfomycin tromethamine
- CAS No.
- 78964-85-9
- Chemical Name:
- Fosfomycin tromethamine
- Synonyms
- FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;z1282;monuril;Fosfomycin tramine;Fosfomycin tromethanol;Fosfomycine Trometamol;fosfomycin tromethamine
- CBNumber:
- CB9365184
- Molecular Formula:
- C7H18NO7P
- Molecular Weight:
- 259.19
- MDL Number:
- MFCD01706261
- MOL File:
- 78964-85-9.mol
- MSDS File:
- SDS
| Melting point | 122-125oC |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChI | InChI=1/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/s3 |
| InChIKey | QZJIMDIBFFHQDW-LMLSDSMGSA-N |
| SMILES | C(N)(CO)(CO)CO.P([C@H]1O[C@H]1C)(O)(O)=O |&1:9,11,r| |
| FDA UNII | 7FXW6U30GY |
| NCI Drug Dictionary | fosfomycin tromethamine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H317-H334-H315 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2941906000 |
Fosfomycin tromethamine price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F0400000 | Fosfomycin trometamol European Pharmacopoeia (EP) Reference Standard | 78964-85-9 | f0400000 | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1286322 | Fosfomycin trometamol | 78964-85-9 | 800mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2512 | Fosfomycin Trometamol | 78964-85-9 | 20MG | $125 | 2023-06-20 | Buy |
| Cayman Chemical | 23632 | Fosfomycin Trometamol ≥98% | 78964-85-9 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 23632 | Fosfomycin Trometamol ≥98% | 78964-85-9 | 10mg | $65 | 2024-03-01 | Buy |
Fosfomycin tromethamine Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
Phosphonic acid derivative; antibacterial.
Uses
Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.
Definition
ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.
brand name
Monurol (Zambon).
General Description
Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
Fosfomycin tromethamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dorra Pharmaceutical Technology Co., Ltd | 025-82232955; | info@dorrapharma.com | China | 34 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5855 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18140 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21631 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29865 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
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- Aug 28，2019
View Lastest Price from Fosfomycin tromethamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-17 | Fosfomycin tromethamine
78964-85-9
|
US $100.00 / KG | 1KG | 99% | 5000kg/week | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-03-13 | Fosfomycin tromethamine
78964-85-9
|
US $0.00 / Kg/Bag | 1KG | 98%-102%; EP | 100KG | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-03-07 | Fosfomycin Tromethamine
78964-85-9
|
US $0.00-0.00 / kg | 1kg | 99% | 3000kg | Hebei Yanxi Chemical Co., Ltd. |
-
- Fosfomycin tromethamine
78964-85-9
- US $100.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- Fosfomycin tromethamine
78964-85-9
- US $0.00 / Kg/Bag
- 98%-102%; EP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fosfomycin Tromethamine
78964-85-9
- US $0.00-0.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.