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Fosfomycin tromethamine

Fosfomycin tromethamine
Fosfomycin tromethamine structure
CAS No.
78964-85-9
Chemical Name:
Fosfomycin tromethamine
Synonyms
z1282;monuril;FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;fosfomycin tromethamine;Fosfomycin Tromethaminel;fosfomycintrometamolsalt;Tromethamine fosfosmycin
CBNumber:
CB9365184
Molecular Formula:
C7H18NO7P
Formula Weight:
259.19
MOL File:
78964-85-9.mol

Fosfomycin tromethamine Properties

solubility 
Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
InChIKey
QZJIMDIBFFHQDW-LMLSDSMGSA-N
FDA UNII
7FXW6U30GY
NCI Drug Dictionary
fosfomycin tromethamine
SAFETY
  • Risk and Safety Statements
HS Code  2941906000

Fosfomycin tromethamine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F0400000 Fosfomycin trometamol European Pharmacopoeia (EP) Reference Standard 78964-85-9 f0400000 $190 2020-08-18 Buy
Sigma-Aldrich F0400000 Fosfomycin trometamol European Pharmacopoeia (EP) Reference Standard 78964-85-9 $190 2021-03-22 Buy
Sigma-Aldrich 1286322 Fosfomycin trometamol 78964-85-9 800mg $366 2021-03-22 Buy
Cayman Chemical 23632 Fosfomycin Trometamol ≥98% 78964-85-9 5mg $29 2021-03-22 Buy
Cayman Chemical 23632 Fosfomycin Trometamol ≥98% 78964-85-9 10mg $52 2021-03-22 Buy

Fosfomycin tromethamine Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Phosphonic acid derivative; antibacterial.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Fosfomycin tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products


Fosfomycin tromethamine Suppliers

Global( 175)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hangzhou Huarong Pharm Co., Ltd.
+8613588754946 +86-571-86758373
0086-571-81131109 sales@huarongpharm.com CHINA 3149 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Yingrui Biopharma Co.,Ltd
+86-21-33585366
+86-21-34979012 export01@shyrchem.com CHINA 1321 58

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View Lastest Price from Fosfomycin tromethamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 Fosfomycin tromethamine
78964-85-9
US $8.00 / KG 100g 99% 1000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-09-29 Fosfomycin tromethamine
78964-85-9
US $0.00 / Kg/Bag 1KG 98%-102%; EP 100KG WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-15 Fosfomycin tromethamine
78964-85-9
US $0.00 / KG 1KG 99% 1000KG Hangzhou Huarong Pharm Co., Ltd.

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