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Fosfomycin tromethamine

Fosfomycin tromethamine
Fosfomycin tromethamine structure
CAS No.
78964-85-9
Chemical Name:
Fosfomycin tromethamine
Synonyms
z1282;monuril;FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;tromethamine-fosfomycin;fosfomycin tromethamine;phosphomycin trometamol;Tromethamine fosfosmycin;Fosfomycin Tromethaminel;fosfomycintrometamolsalt
CBNumber:
CB9365184
Molecular Formula:
C7H18NO7P
Formula Weight:
259.19
MOL File:
78964-85-9.mol

Fosfomycin tromethamine Properties

solubility 
Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
InChIKey
QZJIMDIBFFHQDW-LMLSDSMGSA-N
SAFETY
  • Risk and Safety Statements
HS Code  2941906000

Fosfomycin tromethamine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F0400000 Fosfomycin trometamol European Pharmacopoeia (EP) Reference Standard 78964-85-9 f0400000 $179 2018-11-23 Buy
Sigma-Aldrich 1286322 Fosfomycin trometamol 78964-85-9 800mg $352.8 2018-11-20 Buy
Cayman Chemical 23632 Fosfomycin Trometamol ≥98% 78964-85-9 5mg $29 2018-11-19 Buy
Cayman Chemical 23632 Fosfomycin Trometamol ≥98% 78964-85-9 10mg $52 2018-11-19 Buy
Cayman Chemical 23632 Fosfomycin Trometamol ≥98% 78964-85-9 25mg $174 2018-11-19 Buy

Fosfomycin tromethamine Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Phosphonic acid derivative; antibacterial.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Fosfomycin tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products


Fosfomycin tromethamine Suppliers

Global( 94)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8922 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Shandong chuangyingchemical Co., Ltd.
13156170209
sale@chuangyingchem.com CHINA 4419 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 30864 58

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View Lastest Price from Fosfomycin tromethamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Fosfomycin tromethamine
78964-85-9
US $7.00 / ASSAYS 1KG 98% 1000KG career henan chemical co

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