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Methylparaben

Content analysis Toxicity Utilization limitation Chemical properties Application Preparation Category Toxic grading Acute toxicity Flammability hazard characteristics Storage Extinguishing agent
Methylparaben
Methylparaben
CAS No.
99-76-3
Chemical Name:
Methylparaben
Synonyms
Abiol;Moldex;Septos;NIPAGIN;Nigagin;Paraben;Paridol;Solbrol;metaben;Maseptol
CBNumber:
CB0184566
Molecular Formula:
C8H8O3
Formula Weight:
152.15
MOL File:
99-76-3.mol

Methylparaben Properties

Melting point:
125-128 °C(lit.)
Boiling point:
298.6 °C
Density 
1,46g/cm
FEMA 
2710 | METHYL P-HYDROXYBENZOATE
refractive index 
1.4447 (estimate)
Flash point:
280°C
storage temp. 
0-6°C
solubility 
ethanol: soluble0.1M, clear, colorless
form 
Crystalline Powder
color 
White to almost white
Water Solubility 
Slightly soluble in water.
FreezingPoint 
131℃
Merck 
14,6107
BRN 
509801
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
LXCFILQKKLGQFO-UHFFFAOYSA-N
CAS DataBase Reference
99-76-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA Substance Registry System
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22-36
Safety Statements  26-36-24/25-39
RIDADR  UN 2769
WGK Germany  1
RTECS  DH2450000
TSCA  Yes
HS Code  29182930
Hazardous Substances Data 99-76-3(Hazardous Substances Data)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P273 Avoid release to the environment.

Methylparaben price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 47889 Methyl Paraben analytical standard 99-76-3 1EA $16.5 2017-11-08 Buy
Sigma-Aldrich 1432005 Methylparaben United States Pharmacopeia (USP) Reference Standard 99-76-3 125mg $282.1 2017-11-08 Buy
TCI Chemical H0216 Methyl 4-Hydroxybenzoate >99.0%(HPLC)(T) 99-76-3 25g $16 2017-12-01 Buy
TCI Chemical H0216 Methyl 4-Hydroxybenzoate >99.0%(HPLC)(T) 99-76-3 500g $44 2017-12-01 Buy
Alfa Aesar A14289 Methyl 4-hydroxybenzoate, 99% 99-76-3 250g $38 2017-11-08 Buy

Methylparaben Chemical Properties,Uses,Production

Content analysis

Method one: determinate according to the content analysis method in "butyl p-hydroxybenzoate (07002)". Per mL 1 mol/L sodium hydroxide is equivalent to the product (C8H8O3) 152.2mg.
Method two: Take 0.1 g (accurate to 1 mg) of the sample previously dried on silica gel for 5 h and move into a 300 ml flask with a glass plug. Plus l mol/L sodium hydroxide 10ml, heated in the water bath for 15min. After cooling, add 0.1mol/L potassium bromate 0.00ml, potassium bromide 5.0g and l mol/L hydrochloric acid 30ml. Put 15min in the dark room after sealing. Add potassium iodide 1 g, shake the flask vigorously, with 0.1mol/L sodium thiosulfate titration, with starch test solution (TS-235) as an indicator. Per ml 0.1mol/L potassium bromate is equivalent to the product (C8H8O3) 25.36mg.

Toxicity

ADI 0~10mg/kg(FAO/WHO,2001).
GRAS(FDA,§184.1490,2000).
LD503000mg/kg(Dog, mouth)

Utilization limitation

FAO/WHO (1984): Jam, jelly, 1000mg/kg (single or with benzoate, sorbic acid and potassium sorbate).
EEC(1990,mg/kg): For use in pigment solutions, flavor syrups, coffee extracts, frozen drinks, fruit, glucose and soft drinks, pickled fish, salad, sauce, snack food, concentrated soup and so on, limited to GMP; Beer 70; Snack cereals and soup concentrate 175, the same as "07018 p-hydroxybenzoate".
HACSG is listed as a restricted list.
FDA,§184.1490(2000):0.1%.

Chemical properties

White needle crystal; Slightly soluble in water, easily soluble in ethanol, ether, acetone and other organic solvents.

Application

Preparation

The drug is esterified with p-hydroxybenzoic acid and methanol. The p-hydroxybenzoic acid was added to excess methanol to dissolve, stirring and adding concentrated sulfuric acid slowly. After heating and refluxing 10h, pour into the water to precipitate crystallization, then washed with water, sodium carbonate solution and water, finally obtain the crude product. Recrystallize from water or 25% ethanol to obtain finished product. The yield was 85%. Raw material consumption (kg/t): p-hydroxybenzoic acid 1200, methanol 1000.

Category

Toxic Chemicals

Toxic grading

Moderate toxicity

Acute toxicity

Abdomen-mouse LD50: 960 mg/kg

Flammability hazard characteristics

Combustible, excretes spicy smoke from fireground

Storage

Ventilated , low temperature and dry warehouse.

Extinguishing agent

Water, carbon dioxide, dry powder, sand.

Chemical Properties

white crystalline powder

Uses

It is used as preservative in foods, beverages and cosmetics.

Definition

ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.

Uses

As preservative in foods, beverages and cosmetics.

Purification Methods

Fractionally crystallise the ester from its melt, and recrystallise it from *benzene, then from *benzene/MeOH and dry it over CaCl2 in a vacuum desiccator. [Beilstein 10 IV 360.]

Methylparaben Preparation Products And Raw materials

Raw materials

Preparation Products


Methylparaben Suppliers

Global( 410)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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View Lastest Price from Methylparaben manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Methylparaben
99-76-3
US $1.00 / KG 1G 98% 100KG
2018-07-26 Methylparaben
99-76-3
US $110.00 / KG 1KG 99% 1000kg

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