Methyl 2,6-dibromopyridine-4-carboxylate
- CAS No.
- 119308-57-5
- Chemical Name:
- Methyl 2,6-dibromopyridine-4-carboxylate
- Synonyms
- Methyl 2,6-dibromoisonicotinate;6-dibroMopyridine-4-carboxylate;Methyl 2,6-dibromopyridine-4-carboxylate;2,6-Dibromo Pyridine 4-Carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2,6-dibroMo-, Methyl ester;Methyl 2,6-dibromopyridine-4-carboxylate, 2,6-Dibromo-4-(methoxycarbonyl)pyridine
- CBNumber:
- CB02130932
- Molecular Formula:
- C7H5Br2NO2
- Molecular Weight:
- 294.93
- MDL Number:
- MFCD11042543
- MOL File:
- 119308-57-5.mol
- MSDS File:
- SDS
| Melting point | 86.8-88.2 °C(Solv: hexane (110-54-3)) |
|---|---|
| Boiling point | 320.9±37.0 °C(Predicted) |
| Density | 1.928±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -5.78±0.10(Predicted) |
| Appearance | White to off-white Solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280-P271 |
| HS Code | 2933399990 |
Methyl 2,6-dibromopyridine-4-carboxylate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR18036 | Methyl 2,6-dibromoisonicotinate >97% | 119308-57-5 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR18036 | Methyl 2,6-dibromoisonicotinate >97% | 119308-57-5 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR18036 | Methyl 2,6-dibromoisonicotinate >97% | 119308-57-5 | 5g | $26 | 2026-06-04 | Buy |
| Activate Scientific | AS56527 | Methyl 2,6-dibromopyridine-4-carboxylate 97% | 119308-57-5 | 1g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS56527 | Methyl 2,6-dibromopyridine-4-carboxylate 97% | 119308-57-5 | 5g | $61 | 2026-06-04 | Buy |
Methyl 2,6-dibromopyridine-4-carboxylate Chemical Properties, Uses, Production
Uses
Methyl 2,6-dibromopyridine-4-carboxylate can be used as organic synthesis intermediate or pharmaceutical intermediate. It can also be used to prepare nanostructured coating materials.
Synthesis
67-56-1
99-11-6
119308-57-5
General procedure for the synthesis of methyl 2,6-dibromoisonicotinate from methanol and citrazinic acid: citrazinic acid (5.0 g, 32.2 mmol) was mixed with phosphorus tribromide (POBr3, 27.5 g, 96.8 mmol) and the reaction was heated at 130 °C. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and methanol (250 mL) was slowly added to quench the reaction. Subsequently, the mixture was concentrated under reduced pressure and later separated by extraction with dichloromethane and saturated sodium bicarbonate solution. The aqueous layer was washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown solid product. The product was analyzed by nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LCMS) to confirm that the purity was sufficient for the subsequent reaction (79% yield, 7.5 g). Mass spectrometry (ESI) m/z: 295.8 (M+1). 1H NMR (400 MHz, CD2Cl2) δppm: 8.10 (s, 2H), 4.05 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5422 - 5438
[2] Patent: WO2009/150230, 2009, A1. Location in patent: Page/Page column 65
[3] European Journal of Inorganic Chemistry, 2010, # 13, p. 1913 - 1928
[4] Journal of Organic Chemistry, 2006, vol. 71, # 12, p. 4696 - 4699
[5] Synthesis, 2008, # 17, p. 2764 - 2770
Methyl 2,6-dibromopyridine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2,6-dibromopyridine-4-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Chimica Laboratories Co., Ltd | 0086-573-82585213 | bai@chimicalabs.com | China | 861 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Suzhou Crst Pharmatech Co., Ltd. | 0512-62910395 17751098781 | sales@crstpharma.com | China | 497 | 58 |
View Latest Price from Methyl 2,6-dibromopyridine-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | Methyl 2,6-dibromopyridine-4-carboxylate
119308-57-5
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- Methyl 2,6-dibromopyridine-4-carboxylate
119308-57-5
- $1.00
- 99%
- Career Henan Chemical Co
