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ChemicalBook >> CAS DataBase List >>2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Structure
2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one structure
CAS No.
1035219-96-5
Chemical Name:
2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
Synonyms
2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H);2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one;2-brome-6,7-dihydrothiazole[5,4-C]pyridin-4(5H)-one;Thiazolo[5,4-c]pyridin-4(5H)-one, 2-bromo-6,7-dihydro-;2-bromo-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one;2-bromo-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-4-one;2-Bromo-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one
CBNumber:
CB02469072
Molecular Formula:
C6H5BrN2OS
Molecular Weight:
233.09
MDL Number:
MFCD14706758
MOL File:
1035219-96-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:01
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2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Properties

Boiling point 487.7±34.0 °C(Predicted)
Density 1.825±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 12.76±0.20(Predicted)
Appearance Light yellow to green yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth KRB21996 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 0.5g $584.1 2026-06-04 Buy
Biosynth KRB21996 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 1g $973.5 2026-06-04 Buy
Biosynth KRB21996 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 2g $1298 2026-06-04 Buy
Biosynth KRB21996 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 5g $2596 2026-06-04 Buy
Biosynth KRB21996 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 10g $4543 2026-06-04 Buy
Product number Packaging Price Buy
KRB21996 0.5g $584.1 Buy
KRB21996 1g $973.5 Buy
KRB21996 2g $1298 Buy
KRB21996 5g $2596 Buy
KRB21996 10g $4543 Buy

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Chemical Properties, Uses, Production

Uses

2-Bromo-6,7-dihydrothiazo[5,4-C]pyridine-4(5H)-one is a pyridine organic compound that can be used as an organic intermediate.

Synthesis

2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

26493-11-8

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

1035219-96-5

The general procedure for the synthesis of 2-bromo-6,7-dihydrothiazolo[5,4-b]pyridin-4(5H)-ones using 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-ones as starting material was as follows: intermediate 3 (8 g, 39.8 mmol), copper(II) bromide (10.43 g, 46.68 mmol) and 3-methyl-1- Nitrosoxybutane (6.8 g, 58.35 mmol) were dissolved in acetonitrile (100 mL) and the reaction was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation. The resulting residue was dissolved in ethyl acetate and washed with water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent was evaporated in vacuum to give Intermediate 4 (5 g, 55% yield), which could be used in subsequent steps without further purification.

References

[1] Patent: WO2011/73339, 2011, A1. Location in patent: Page/Page column 43
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 14, p. 4037 - 4043
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 66; 67

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Preparation Products And Raw materials

Raw materials

2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride 2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Acetonitrile Isoamyl nitrite Cupric bromide

Preparation Products

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Suppliers

Global Suppliers ( 52)
Supplier Tel Email Country ProdList Advantage
Adamas Reagent, Ltd. 4006009262 13023226327 hmj@titansci.com China 14098 59
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Shanghai Keepontech Co.,Ltd 021-54849683 13601642561 sales@keepontech.com China 1000 59
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9329 58
Chengdu J&B Technology Co., Ltd. 028-61186694 15608078506 609128801@qq.com China 853 55
BioPharmaMatrix,Inc. 0510-86010668 13395169561; sales@biopharmamatrix.com China 5035 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 10000 58
Supplier Advantage
Adamas Reagent, Ltd. 59
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Keepontech Co.,Ltd 59
Bide Pharmatech Ltd. 60
Finetech Industry Limited 58
Chengdu J&B Technology Co., Ltd. 55
BioPharmaMatrix,Inc. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Spectrum

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE(1035219-96-5)1HNMR

1035219-96-5 (2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one) Related Search:

2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 2-bromo-6,7-dihydro-4-oxo-, 1,1-dimethylethyl ester 2-Bromo-7-methyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
2-Bromo-7-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester

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2-brome-6,7-dihydrothiazole[5,4-C]pyridin-4(5H)-one 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H) Thiazolo[5,4-c]pyridin-4(5H)-one, 2-bromo-6,7-dihydro- 2-Bromo-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one 2-bromo-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-4-one 2-bromo-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 1035219-96-5 C6H5BrN2OS