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(+/-)-trans-1,2-Diaminocyclohexane

(+/-)-trans-1,2-Diaminocyclohexane Structure
(+/-)-trans-1,2-Diaminocyclohexane structure
CAS No.
1121-22-8
Chemical Name:
(+/-)-trans-1,2-Diaminocyclohexane
Synonyms
TRANS-1,2-CYCLOHEXANEDIAMINE;Cyclohexanediamine;(±)-trans-1,2-Diaminocyclohexane;TIMTEC-BB SBB007639;trans-1,2-cyclohexyldiamine;trans-1,2-Cyclohexanedi;Oxaliplatin Impurity 16;(±)-trans-1,2-DiaminocycL;trans-1,2-Diaminocyclohex;trans-1,2-Cyclohexaneiamine
CBNumber:
CB0247786
Molecular Formula:
C6H14N2
Molecular Weight:
114.19
MDL Number:
MFCD00063747
MOL File:
1121-22-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:24:33
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(+/-)-trans-1,2-Diaminocyclohexane Properties

Melting point 14-15 °C(lit.)
Boiling point 79-81 °C15 mm Hg(lit.)
Density 0.951 g/mL at 25 °C(lit.)
vapor pressure 0.4 mm Hg ( 20 °C)
refractive index n20/D 1.489(lit.)
Flash point 156 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 9.94(at 20℃)
form Liquid
color Clear colorless to light yellow
Water Solubility Soluble
Sensitive Air Sensitive
BRN 506142
InChI 1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1
InChIKey SSJXIUAHEKJCMH-WDSKDSINSA-N
SMILES N[C@@H]1CCCC[C@H]1N
CAS DataBase Reference 1121-22-8(CAS DataBase Reference)
FDA UNII 37EKL250EE
NIST Chemistry Reference trans-1,2-Cyclohexanediamine(1121-22-8)
EPA Substance Registry System 1,2-Cyclohexanediamine, (1R,2R)-rel- (1121-22-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 2735 8/PG 2
WGK Germany  3
F  10-34
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29213000
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
REACH Registrations Active
NFPA 704
1
3 0

(+/-)-trans-1,2-Diaminocyclohexane price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 270016 (±)-trans-1,2-Diaminocyclohexane 99% 1121-22-8 10ml $39.8 2026-04-30 Buy
Sigma-Aldrich 270016 (±)-trans-1,2-Diaminocyclohexane 99% 1121-22-8 50ml $131 2026-04-30 Buy
TCI Chemical C1120 trans-1,2-Cyclohexanediamine >97.0%(GC)(T) 1121-22-8 25mL $38 2026-04-30 Buy
TCI Chemical C1120 trans-1,2-Cyclohexanediamine >97.0%(GC)(T) 1121-22-8 250mL $190 2026-04-30 Buy
TRC TRC-D416095-5G (±)-trans-1,2-Diaminocyclohexane 1121-22-8 5g $78 2026-06-03 Buy
Product number Packaging Price Buy
270016 10ml $39.8 Buy
270016 50ml $131 Buy
C1120 25mL $38 Buy
C1120 250mL $190 Buy
TRC-D416095-5G 5g $78 Buy

(+/-)-trans-1,2-Diaminocyclohexane Chemical Properties, Uses, Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(±)-trans-1,2-Diaminocyclohexane was used in the synthesis of macrocyclic [3+3] hexa Schiff base. It was also employed in the synthesis of multidentate ligands, chiral auxiliaries and chiral stationary phases.

Uses

(^+)-trans-1,2-Diaminocyclohexane is employed in the synthesis of macrocyclic [3+3] hexa Schiff base. It also plays an important role in the preparation of multidentate ligands, chiral auxiliaries and chiral stationary phases. Further, it is used to prepare [2+2] macrocyclization by reacting with aliphatic dialdehydes. In addition to this, it acts as a chiral ligand, which finds application in asymmetric catalysis.

General Description

(±)-trans-1,2-Diaminocyclohexane was condensed with aliphatic dialdehydes to form [3+3] or [2+2] macrocyclization products.

Synthesis

7-Aza-bicyclo[4.1.0]heptane

286-18-0

(+/-)-trans-1,2-Diaminocyclohexane

1121-22-8

General procedure for the synthesis of trans-1,2-cyclohexanediamine from epoxycyclohexane (CAS:286-18-0): 1. Epoxycyclohexane (39.2 g, 0.4 mol) and 30% ammonia (1.0 mol) were added to a reaction flask. The reaction was stirred at room temperature for 1.5 hours until the solution gradually clarified, indicating completion of the reaction. 2. The reaction mixture was cooled to room temperature under reduced pressure to give a white solid. Add 35 g of water to completely dissolve the solid and then cool to 0°C. 3. Slowly add 50% aqueous sulfuric acid solution, controlling the temperature throughout the process not to exceed 30°C. After stirring, gradually heat to 80°C under reduced pressure to remove the water, the system gradually becomes viscous and solidified. Stop stirring and continue vacuuming for 4 hours. 4. The solid was removed and pulverized and continued to be dried under vacuum at 120°C for 12 h. Moisture was measured to be 0.22% by Karl Fischer titration. 5. in another reaction flask, add sodium hydroxide solution and heat to 40°C, add the above solid powder in batches, controlling the temperature not to exceed 50°C. After addition, raise the temperature to 60°C, stirring until complete clarification, the reaction was completed at pH 9-10. 6. Extraction and distillation with 1,2-dichloroethane gave 27.2 g of aziridine with a GC purity of 99.6% and a total yield of 70% in two steps. 7. Aziridine (27.2 g, 0.28 mol), 30% ammonia (0.48 mol) and inorganic boric acid (3.5 g, 56 mmol) were mixed and heated to 90-95°C for overnight reaction. 8. Upon completion of the reaction, trans-1,2-cyclohexanediamine was obtained by distillation under reduced pressure, which solidified after cooling to 28.1 g of white solid with a GC purity of 99.7% and a yield of 88%, no cis isomers were detected, and the HNMR spectrum was consistent with the literature.

Purification Methods

Purify and store the diamine as for the cis-isomer above as it is a strong base and becomes yellow on storage. [Beilstein 13 IV 1.]

References

[1] Bulletin de la Societe Chimique de France, 1956, p. 382,387,1827
[2] Patent: CN106631815, 2017, A. Location in patent: Paragraph 0013; 0014; 0015

(+/-)-trans-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

7-Aza-bicyclo[4.1.0]heptane

Preparation Products

(1R,2R)-(-)-1,2-Diaminocyclohexane (1S,2S)-(+)-1,2-Diaminocyclohexane (1R,2R)-(+)-1,2-Diaminocyclohexane L-tartrate

(+/-)-trans-1,2-Diaminocyclohexane Suppliers

Global Suppliers ( 380)
Supplier Tel Email Country ProdList Advantage
Shanghai Chiyuan Technology Co., Ltd 13818304948 55992407@qq.com China 124 58
Jinan Yuantai Pharmaceutical Co.,Ltd 0531-69959492 18366108822 85633700@qq.com China 81 55
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1991 58
Fuxin Kaituo Fine Chemical Technology Co., Ltd 15714082442 15714082442@163.com China 241 58
Shandong Chenyi Environmental Protection Technology Co., Ltd 1856-0179988 13355310698 thezzc@outlook.com China 259 58
Qufu Haida Tiancheng Biochemical Co., Ltd. 0537-4531868 18553729317 qfhdtc@126.com China 87 55
Shandong Chenyi Environmental Protection Technology Co., Ltd 0531-83179999 13395316108 cyhbkjyxgs@163.com China 198 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1965 58
Jinan Sunshine Pharmaceutical Co.,Ltd. 531-82812892 18668915976 sales@sunshinepharm.com.cn China 29 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Shanghai Chiyuan Technology Co., Ltd 58
Jinan Yuantai Pharmaceutical Co.,Ltd 55
Chengdu Forest Science and Technology Development Co., Ltd. 58
Fuxin Kaituo Fine Chemical Technology Co., Ltd 58
Shandong Chenyi Environmental Protection Technology Co., Ltd 58
Qufu Haida Tiancheng Biochemical Co., Ltd. 55
Shandong Chenyi Environmental Protection Technology Co., Ltd 58
Shanghai Moss Medicine Technology Co., Ltd. 58
Jinan Sunshine Pharmaceutical Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76

View Latest Price from (+/-)-trans-1,2-Diaminocyclohexane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(+/-)-trans-1,2-Diaminocyclohexane pictures 2026-10-16 (+/-)-trans-1,2-Diaminocyclohexane
1121-22-8
 $20.00-141.00 25g 0.99 25kg Shanghai UCHEM Inc.
(+/-)-trans-1,2-Diaminocyclohexane pictures 2026-09-02 (+/-)-trans-1,2-Diaminocyclohexane
1121-22-8
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
(R,R)-(-)-1,2-Diaminocyclohexane pictures 2026-09-02 (R,R)-(-)-1,2-Diaminocyclohexane
1121-22-8
 $1.00-50.00 1KG 99 Henan Fengda Chemical Co., Ltd

(+/-)-trans-1,2-Diaminocyclohexane Spectrum

(+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)1HNMR(+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)Raman(+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)IR

1121-22-8 ((+/-)-trans-1,2-Diaminocyclohexane) Related Search:

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(+/-)-TRANS-1,2-CYCLOHEXANEDIAMINE 1,2-Cyclohexanediamine, trans- trans-1,2-Cyclohexaneiamine Trans-(L)-1,2-Diaminecyclohexane trans-1,2-Diaminocyclohexane(Racemic) Diaminocyclohexane,trans-1,2- (n)-trans-1,2-cyclohexanediamine (n)-trans-1,2-diaminocyclohexane (+/-)-trans-1,2-Diaminocyclohexane 1,2-TRAMS-DIAMINOCYCLOHEXANE rel-(1R*,2R*)-1,2-Cyclohexanediamine rel-(1R*,2R*)-Cyclohexane-1,2-diamine (±)-trans-1,2-Diaminocyclohexane,98% trans-1,2-Cyclohexanedi (+/-)-trans-1,2-Diaminocyclohexane ,99% (±)-trans-1,2-Diaminocyclohexane,(±)-trans-1,2-Cyclohexanediamine (§1)-trans-1,2-Diaminocyclohexane, 98% (+/-)-trans-1,2-DiaMinocyclohexane 99% trans-1,2-Cyclohexanediamine (±)-trans-1,2-DiaminocycL trans-1,2-Diaminocyclohex trans-1,2-Cyclohexanediamine> 1,2-Cyclohexanediamine, (1R,2R)-rel- Trans-1,2-diaminocyclohexane -1，2- TIANFUCHEM-- 1121-22-8 -- (+/-)-trans-1,2-Diaminocyclohexane in stock TIMTEC-BB SBB007639 (±)-trans-1,2-Diaminocyclohexane (±)-trans-1,2-Diaminocyclohexane -trans-1,2-Diaminocyclohexane Oxaliplatin Impurity 16 (±)-trans-1,2-Diaminocyclohexane Cyclohexanediamine TRANS-1,2-CYCLOHEXANEDIAMINE trans-1,2-cyclohexyldiamine β-Amyloid (1-40) (human) TFA 1121-22-8 112-22-8 Polyamines Organic Building Blocks Nitrogen Compounds Building Blocks bc0001