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ChemicalBook >> CAS DataBase List >>5-BroMo-3,4-dihydroisoquinolin-1(2H)-one

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Structure
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one structure
CAS No.
1109230-25-2
Chemical Name:
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
Synonyms
4-dihydroisoquinolin-1(2H)-one;5-Bromo-3,4-dihydroisoquinolin-1(2H);5-BroMo-3,4-dihydroisoquinolin-1(2H)-one;5-bromo-3,4-dihydro-1(2H)-Isoquinolinone;5-Bromo-3,4-dihydro-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 5-bromo-3,4-dihydro-;5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one
CBNumber:
CB02549949
Molecular Formula:
C9H8BrNO
Molecular Weight:
226.07
MDL Number:
MFCD11847788
MOL File:
1109230-25-2.mol
Last updated:2025-07-24 18:13:42
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5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Properties

Melting point 180-183℃
Boiling point 453.8±45.0 °C(Predicted)
Density 1.559
storage temp. Sealed in dry,Room Temperature
pka 14.34±0.20(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319-H335-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B691363 5-Bromo-3,4-dihydroisoquinolin-1(2h)-one 1109230-25-2 25mg $45 2021-12-16 Buy
TRC B691363 5-Bromo-3,4-dihydroisoquinolin-1(2h)-one 1109230-25-2 250mg $75 2021-12-16 Buy
Ark Pharm P000250939 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one 97% 1109230-25-2 1g $149 2021-12-16 Buy
ChemScene CS-W006085 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one 1109230-25-2 5g $580 2021-12-16 Buy
Ark Pharm P000250939 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one 97% 1109230-25-2 5g $594 2021-12-16 Buy
Product number Packaging Price Buy
B691363 25mg $45 Buy
B691363 250mg $75 Buy
P000250939 1g $149 Buy
CS-W006085 5g $580 Buy
P000250939 5g $594 Buy

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Uses,Production

Synthesis

4-Bromo-1-indanone

15115-60-3

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one

1109230-25-2

The general procedure for the synthesis of 5-bromo-3,4-dihydroisoquinolin-1(2H)-one using 4-bromoindan-1-one as starting material was as follows: 4-bromoindan-1-one (4.00 g, 18.9 mmol) and methanesulfonic acid (20.2 mL, 310 mmol) were dissolved in dichloromethane (180 mL) at 0 °C, followed by the slow addition of sodium azide (2.46 g, 37.9 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into 10% aqueous sodium hydroxide solution (200 mL) and extracted with dichloromethane (100 mL). The organic layers were combined and dried over anhydrous sodium sulfate, followed by concentration under reduced pressure to remove the solvent. The crude product was purified by recrystallization from ethyl acetate (40 mL) to afford the target compound 5-bromo-3,4-dihydroisoquinolin-1(2H)-one (3.98 g, 17.6 mmol, 93% yield) as a white powder. The product was analyzed by LCMS showing a purity of 96% with a retention time (Rt) of 1.225 min, and electrospray ionization mass spectrometry (ESMS) showing a m/z of 226 ([M+H]+).

References

[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0106-0107
[2] Patent: WO2015/20553, 2015, A1. Location in patent: Paragraph 00111-00112
[3] Patent: WO2015/50472, 2015, A1. Location in patent: Paragraph 00109; 00110
[4] Patent: WO2015/50471, 2015, A1. Location in patent: Paragraph 00105; 00106
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2670 - 2674

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

methyl 2-bromophenethylcarbamate 4-Bromo-1-indanone Dichloromethane Methanesulfonic acid Sodium azide

Preparation Products

5-BROMOISOQUINOLIN-1(2H)-ONE 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 2-Allyl-5-broMo-3,4-dihydroisoquinolin-1(2H)-one

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5661 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		+86-0512-83500002 +8618662433356 3899766280@qq.com China 26362 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
Shanghai Likang New Materials Co., Limited 		+86-16631818819 +86-17736933208 3684455296@qq.com China 9300 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Adamas Reagent, Ltd. 400-6009262 16621234537 chenyj@titansci.com China 14101 59
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Shanghai Likang New Materials Co., Limited 		58
Amadis Chemical Company Limited 		58
Adamas Reagent, Ltd. 59

View Lastest Price from 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one pictures 2020-01-08 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
1109230-25-2
 US $0.01 / KG 1KG 98%； 99% 1kg; 5kg; 10kg；25kg Career Henan Chemical Co

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one Spectrum

5-BroMo-3,4-dihydroisoquinolin-1(2H)-one(1109230-25-2)1HNMR

1109230-25-2(5-BroMo-3,4-dihydroisoquinolin-1(2H)-one)Related Search:

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4-dihydroisoquinolin-1(2H)-one 5-Bromo-3,4-dihydro-2H-isoquinolin-1-one 5-bromo-3,4-dihydro-1(2H)-Isoquinolinone 5-Bromo-3,4-dihydroisoquinolin-1(2H) 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one 5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one 1(2H)-Isoquinolinone, 5-bromo-3,4-dihydro- 1109230-25-2