5-Bromo-3-cyano-2-hydroxypyridine
- CAS No.
- 405224-22-8
- Chemical Name:
- 5-Bromo-3-cyano-2-hydroxypyridine
- Synonyms
- 5-bromo-2-hydroxynicotino...;5-Bromo-3-cyano-2(1H)-pyridinone;5-BROMO-2-HYDROXYNICOTINONITRILE;5-BROMO-3-CAYNO-2(1H)-PYRIDINONE;5-BROMO-3-CYANO-2-HYDROXYPYRIDINE;5-Bromo-2-hydroxynicotinonitrile98%;5-Bromo-2-hydroxynicotinonitrile 98%;5-Bromo-3-cyano-2-hydroxypyridine 98%;5-bromo-2-hydroxypyridine-3-carbonitrile;5-BROMO-2-HYDROXY-3-PYRIDINECARBONITRILE
- CBNumber:
- CB3429637
- Molecular Formula:
- C6H3BrN2O
- Molecular Weight:
- 199
- MDL Number:
- MFCD07363806
- MOL File:
- 405224-22-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-3-cyano-2(1H)-pyridinone | B683373 | 1g | $75 |
| 5-Bromo-3-cyano-2(1H)-pyridinone | FB32877 | 500mg | $90 |
| 5-Bromo-3-cyano-2(1H)-pyridinone | J50864 | 10g | $100 |
| 5-Bromo-2-hydroxynicotinonitrile 98% | 4H37-9-X8 | 1g | $115 |
| 5-Bromo-3-cyano-2(1H)-pyridinone | FB32877 | 1g | $157.5 |
| More product size | |||
| Melting point | 219-221 |
|---|---|
| Boiling point | 292.1±40.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | 6.87±0.10(Predicted) |
| color | Beige |
| InChI | InChI=1S/C6H3BrN2O/c7-5-1-4(2-8)6(10)9-3-5/h1,3H,(H,9,10) |
| InChIKey | SWTLLSLCDHXNIU-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(Br)C=C1C#N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Bromo-3-cyano-2-hydroxypyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B683373 | 5-Bromo-3-cyano-2(1H)-pyridinone | 405224-22-8 | 1g | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB32877 | 5-Bromo-3-cyano-2(1H)-pyridinone | 405224-22-8 | 500mg | $90 | 2021-12-16 | Buy |
| AK Scientific | J50864 | 5-Bromo-3-cyano-2(1H)-pyridinone | 405224-22-8 | 10g | $100 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H37-9-X8 | 5-Bromo-2-hydroxynicotinonitrile 98% | 405224-22-8 | 1g | $115 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB32877 | 5-Bromo-3-cyano-2(1H)-pyridinone | 405224-22-8 | 1g | $157.5 | 2021-12-16 | Buy |
5-Bromo-3-cyano-2-hydroxypyridine Chemical Properties,Uses,Production
Synthesis
20577-27-9
405224-22-8
General procedure for the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-oxo-1,2-dihydropyridine-3-carbonitrile: 2-oxo-1,2-dihydropyridine-3-carbonitrile (50 mg, 0.42 mmol) and sodium acetate (69 mg, 0.84 mmol) were dissolved in 5 mL of glacial acetic acid at room temperature, and stirred until complete dissolution. Subsequently, bromine (21.5 μL, 0.42 mmol) was slowly added to the solution and the reaction lasted for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the acetic acid. The crude product was purified by column chromatography (using ethyl acetate as eluent) to afford 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (69 mg, 75% yield) as a yellow solid. Melting point: 216~217°C. 1H NMR (400MHz, CD3COCD3): δ11.70 (s, 1H), 8.22 (d, J = 2.8Hz, 1H), 8.05 (d, J = 2.8Hz, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[5] Patent: US2004/19052, 2004, A1. Location in patent: Page/Page column 17
5-Bromo-3-cyano-2-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Yushan Wanfang Biotechnology Co., Ltd. | +86-025-84918180 +86-18014482516 | 3552541679@qq.com | China | 997 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20171 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 5-Bromo-3-cyano-2-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 5-Bromo-2-hydroxynicotinonitrile
405224-22-8
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-06-25 | 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Bromo-2-hydroxynicotinonitrile
405224-22-8
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
405224-22-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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