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(S)-3-Amino-1-N-Boc-piperidine

(S)-3-Amino-1-N-Boc-piperidine Structure
(S)-3-Amino-1-N-Boc-piperidine structure
CAS No.
625471-18-3
Chemical Name:
(S)-3-Amino-1-N-Boc-piperidine
Synonyms
(S)-1-BOC-3-AMINOPIPERIDINE;(S)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE;S-1-BOC-3-aminopiperdine;(S)-1-BOC-3-PIPERIDINAMINE;(S)-1-BOC-3-AMNIOPIPERIDINE;(S)-N-BOC-3-AMINOPIPERIDINE;(S)-3-AMino-1-Boc-piperid...;(S)-3-AMINO-1-BOC-PIPERIDINE;(S)-3-AMINO-N-TBOC-PIPERIDINE;（S）-3-Amino-1-N-Boc-pieridine
CBNumber:
CB0258317
Molecular Formula:
C10H20N2O2
Molecular Weight:
200.28
MDL Number:
MFCD03094718
MOL File:
625471-18-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:25:17
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(S)-3-Amino-1-N-Boc-piperidine Properties

alpha -28.5 º (c=1, DMF)
Boiling point 277.3±33.0 °C(Predicted)
Density 1.02
refractive index 1.4690-1.4730
Flash point 122℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in dimethylsulfoxide.
pka 10.35±0.20(Predicted)
form Gum or Semi-Solid
color Colorless to yellow
optical activity [α]/D +32.0±3°, c = 1 in DMF
Sensitive Air Sensitive
InChI InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m0/s1
InChIKey AKQXKEBCONUWCL-QMMMGPOBSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC[C@H](N)C1
CAS DataBase Reference 625471-18-3(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
RIDADR  2735
WGK Germany  3
F  10-34
HazardClass  8
HS Code  29333990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
3 1

(S)-3-Amino-1-N-Boc-piperidine price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 19929 (S)-(+)-3-Amino-1-Boc-piperidine ≥98.0% (TLC) 625471-18-3 1g $96.6 2026-04-30 Buy
TCI Chemical A2335 (S)-3-Amino-1-tert-butoxycarbonylpiperidine >95.0%(GC)(T) 625471-18-3 1g $108 2026-04-30 Buy
Usbiological 264155 S-1-Boc-3-aminopiperidine Asreported 625471-18-3 1g $373 2026-06-03 Buy
Usbiological 264155 S-1-Boc-3-aminopiperidine Asreported 625471-18-3 2g $519 2026-06-03 Buy
Usbiological 264155 S-1-Boc-3-aminopiperidine Asreported 625471-18-3 5g $711 2026-06-03 Buy
Product number Packaging Price Buy
19929 1g $96.6 Buy
A2335 1g $108 Buy
264155 1g $373 Buy
264155 2g $519 Buy
264155 5g $711 Buy

(S)-3-Amino-1-N-Boc-piperidine Chemical Properties, Uses, Production

Chemical Properties

Light yellow liquid

Uses

(S)-(+)-3-Amino-1-Boc-piperidine is used to prepare selective noncovalent inhibitors of the bacterial cysteine protease IdeS. The product obtained by the reductive elimination reaction with ethylglyoxalte is used as a reference compound, which is used to determine the absolute configuration of the two enantiomers.

Synthesis

1-Piperidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)-

1271240-70-0

(S)-3-Amino-1-N-Boc-piperidine

625471-18-3

General procedure for the synthesis of (S)-1-Boc-3-aminopiperidine from the compound (CAS:1271240-70-0): the azido derivative 42a (6.77 g, 29.9 mmol) was mixed with Pd/C catalyst (150 mg) in ethanol (200 mL) and subjected to a hydrogenation reaction at atmospheric pressure overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration followed by evaporation of the solvent. The product 43a was obtained as a colorless liquid in 90% yield (5.39 g, 26.9 mmol) without further purification. The 1H NMR, 13C NMR and IR spectral data of the product were in agreement with those reported in the literature30 . High-resolution mass spectrometry (HRMS, ESI) analysis showed a calculated and measured value of 201.1598 for C10H21O2N2 ([M + H]+); the specific spin [α]D20 was +26.0 (c 0.308, EtOH).

References

[1] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500
[2] Patent: WO2005/305, 2005, A1. Location in patent: Page 60
[3] Patent: WO2005/20976, 2005, A2. Location in patent: Page/Page column 239
[4] Patent: WO2005/60949, 2005, A2. Location in patent: Page/Page column 238

(S)-3-Amino-1-N-Boc-piperidine synthesis

98977-36-7
625471-18-3
Synthesis of (S)-3-Amino-1-N-Boc-piperidine from 1-Boc-3-piperidone

(S)-3-Amino-1-N-Boc-piperidine Preparation Products And Raw materials

Raw materials

(R)-1-Boc-3-Hydroxypiperidine (R)-Piperidin-3-ol (S)-1-Benzyl-3-hydroxypiperidine (S)-(-)-1-Benzyl-2-pyrrolidinemethanol methyl L-prolinate
1-Boc-3-piperidone Di-tert-butyl dicarbonate 1-Piperidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)- D-Proline Activated carbon

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Preparation Products

Acetone DiMethyl-(S)-piperidin-3-yl-aMine

(S)-3-Amino-1-N-Boc-piperidine Suppliers

Global Suppliers ( 320)
Supplier Tel Email Country ProdList Advantage
Anqing CHICO Pharmaceutical Co., Ltd. 18061456370 david@chicopharm.com China 461 58
Sichuan Argalbio Technology Co,.Ltd 028-028-60651388 13980413900 slyu@hengkangtech.com China 575 58
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Anqing CHICO Pharmaceutical Co., Ltd. 58
Sichuan Argalbio Technology Co,.Ltd 58
Chengdu Firster Pharmaceutical Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from (S)-3-Amino-1-N-Boc-piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1-N-Boc-3-aminopiperidine pictures 2026-08-08 (S)-1-N-Boc-3-aminopiperidine
625471-18-3
 1kg 99.0% 20 tons Hangzhou ICH Biofarm Co., Ltd
(S)-3-Amino-1-N-Boc-piperidine pictures 2022-02-25 (S)-3-Amino-1-N-Boc-piperidine
625471-18-3
 $7.90 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
(S)-3-Amino-1-N-Boc-piperidine pictures 2022-02-25 (S)-3-Amino-1-N-Boc-piperidine
625471-18-3
 $7.90 1KG 98% 10KG Hong Kong Tiansheng New Material Trading Co., Ltd

(S)-3-Amino-1-N-Boc-piperidine Spectrum

(S)-3-Amino-1-N-Boc-piperidine(625471-18-3)1HNMR(S)-3-Amino-1-N-Boc-piperidine(625471-18-3)FT-IR

625471-18-3 ((S)-3-Amino-1-N-Boc-piperidine) Related Search:

1-Boc-3-aminopiperidine 3-Aminopiperidine (R)-1-Boc-3-Aminopiperidine (S)-3-Aminopiperidine 4-AMINO-1-N-BOC-PIPERIDINE
N-BOC-3-Aminopiperidine (S)-3-Amino-1-N-Boc-piperidine 1-Boc-4-amino-piperidine hydrochloride (S)-3-Amino-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (S)-1-Boc-3-(Cbz-amino)-piperidine
(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.2]octane hydrochloride (S)-tert-Butyl 3-(methylsulfonamido)piperidine-1-carboxylate R-3-Dimethylamino-N-Boc-piperidine 1-N-Boc-3-(S)-Methylamino-piperidine (1S,4S)-2-Boc-2,5-diazabicyclo(2.2.2)octane
(S)-1-Boc-3-N-(pyridin-4-ylmethyl)-amino-piperidine 3-(1-Benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester S-3-(Carbamylamino)-N-Boc-piperidine

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(S)-1-Boc-3-piperidinamine, tert-Butyl (S)-3-amino-1-piperidinecarboxylate (S)-(-)-3-Amino-1-Boc-piperidi S-1-BOC-3-aminopiperdine (S)-3-Amino-1-N-Boc-piperidine ,98% (3S)-3-Aminopiperidine, N1-BOC protected (S)-3-AMino-1-tert-butoxycarbonylpiperidine tert-Butyl (3S)-3-aminopiperidine-1-carboxylate, (3S)-3-Amino-1-(tert-butoxycarbonyl)piperidine tert-Butyl (S)-3-aMino-4-piperidinecarboxylate tert-Butyl (S)-3-aMino-2-piperidinecarboxylate tert-Butyl (S)-3-aMino-3-piperidinecarboxylate tert-Butyl (S)-3-aMino-5-piperidinecarboxylate tert-Butyl (S)-3-aMino-6-piperidinecarboxylate (S)-1-Boc-3-AMinopiperidine citric acid salt (S)-3-Amino-1-Boc-piperidine tert-Butyl 3-Amino-1-piperidinecarboxylate (S)-3-AMino-1-Boc-piperid... (S)-t-butyl 3-aMinopiperidine-1-carboxylate (S)-(+)-3-Amino-1-Boc-piperidine,97% (S)-1-tert-Butoxycarbonyl-3-aminopiperidine (S)-1-Boc-3-aminopiperidine,99%e.e. (S)-1-BOC-3-PIPERIDINAMINE (S)-1-BOC-3-AMINOPIPERIDINE HYDROCHLORIDE (S)-1-BOC-3-AMNIOPIPERIDINE (S)-3-AMINO-1-BOC-PIPERIDINE (S)-3-AMINO-1-BOC-PIPERIDINE HYDROCHLORIDE (S)-3-AMINO-1-N-BOC-PIPERIDINE (S)-3-AMINO-N-TBOC-PIPERIDINE (S)-3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL (S)-3-AMINO-1-PIPERIDINECARBOXYLATE (S)-N-BOC-3-AMINOPIPERIDINE (S)-TERT-BUTYL 3-AMINOPIPERIDINE-CARBOXYLATE (S)-(-)-1-N-Boc-3-aminopiperidine 1-Piperidinecarboxylicacid,3-amino-,1,1-dimethylethylester,(3S)-(9CI) 1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3S)- tert-Butyl (3S)-3-aminopiperidine-1-carboxylate tert-butyl 3-aminopiperidine-1-carboxylate (as citrate salt) (S)-3-Aminopiperidine, N1-BOC protected (S)-3-Amino-1-tert-butoxycarbonylpiperidine > (S)-3-aminopiperidine-1-carboxylate (S)-tert-Butyl 3-Amino-1-piperidinecarboxylate (S)-3-Amino-1-N-Boc-piperidine USP/EP/BP tert-Butyl(S)-3-aminopiperidine-1-carboxylate (S)-tert-Butyl 3-amino-piperidin-1-carboxylate （S）-3-Amino-1-N-Boc-pieridine (S)-(+)-3-Amino-1-Boc-piperidine S-3-amino-1-N-Boc-piperidine 98% (S)-1-BOC-3-AMINOPIPERIDINE (S)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE 625471-18-3 625471-18-8 625471-18-4 625471-18-6 625471-18-5 625471-18-7 pharmacetical Amines Pyrans, Piperidines &Piperazines Piperidine Piperidine Series