Boc-NH-PEG2-CH2COOH
- CAS No.
- 108466-89-3
- Chemical Name:
- Boc-NH-PEG2-CH2COOH
- Synonyms
- 2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid;Boc-AEEA-OH;2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid;Boc-O 2 Oc-OH;2-diMethyl-4-oxo-;BocNH-PEG2-CH2COOH;NHBoc-PEG2-CH2COOH;Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-Amido-PEG2-CH2COOH
- CBNumber:
- CB02639228
- Molecular Formula:
- C11H21NO6
- Molecular Weight:
- 263.29
- MDL Number:
- MFCD17019374
- MOL File:
- 108466-89-3.mol
- MSDS File:
- SDS
Boiling point | 425.7±30.0 °C(Predicted) |
---|---|
Density | 1.145±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
pka | 3.40±0.10(Predicted) |
form | liquid |
color | Yellow |
InChI | InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14) |
InChIKey | OMBVJVWVXRNDSL-UHFFFAOYSA-N |
SMILES | C(O)(=O)COCCOCCNC(=O)OC(C)(C)C |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2918999090 |
Boc-NH-PEG2-CH2COOH price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 901577 | t-Boc-N-amido-PEG2-CH2CO2H ≥95% | 108466-89-3 | 50MG | $34.4 | 2023-06-20 | Buy |
TRC | B694050 | 8-tert-Butyloxycarbonylamino-3,6-dioxaoctanoicAcid | 108466-89-3 | 2.5g | $1260 | 2021-12-16 | Buy |
Iris Biotech GmbH | PEG8080 | Boc-O2Oc | 108466-89-3 | 25g | $1350 | 2021-12-16 | Buy |
ChemPep | 280209 | Boc-AEEA | 108466-89-3 | 5g | $250 | 2021-12-16 | Buy |
Apolloscientific | BIPG1825 | t-Boc-N-amido-PEG2-CH2CO2H | 108466-89-3 | 5g | $540 | 2021-12-16 | Buy |
Boc-NH-PEG2-CH2COOH Chemical Properties,Uses,Production
Description
t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Synthesis
To a stirred solution of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (5.0 g, 30.6 mmol) in 1,4-Dioxane (50 mL), Sodium carbonate (8.12 g, 76.5 mmol, dissolved in 10 mL water) and (Boc)2O (9.98 mL, 45.7 mmol) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. The reaction mass was partitioned between diethyl ether and water. Then, the aqueous layer was made acidic (pH = 3) by 3N HC1 solution and was extracted with DCM (2 x 200 mL). The organic layer was washed with water, and brine, dried over Na2504 and evaporated under reduced pressure to yield 50 g of pure Boc-NH-PEG2-CH2COOH (Yield:62.1 per cent).
Boc-NH-PEG2-CH2COOH Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | +8618291886785 | olivia.wang@pushanshiye.com | China | 164 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Boc-NH-PEG2-CH2COOH manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-09 | 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
108466-89-3
|
US $0.00 / kg | 1kg | 98% | 1000 kgs | PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | ||
2019-07-06 | 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid
108466-89-3
|
US $1.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
- 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
108466-89-3
- US $0.00 / kg
- 98%
- PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
- 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid
108466-89-3
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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