ChemicalBook >> CAS DataBase List >>5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester structure

CAS No.: 101187-40-0

Chemical Name:: 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

Synonyms: 13-amino;NH2-PEG3-NHBOC;NHBoc-PEG4-NH2;BOC-NH-PEG3-NH2;Amino-PEG4-NHBoc;NHBoc-PEG3-amine;PROTAC Linker 15;N-Boc-3,6,9-triox;BOC-N-AMIDO-PEG3-NH2;Boc-NH-PEG3-CH2CH2NH2

CBNumber:: CB72470859

Molecular Formula:: C13H28N2O5

Molecular Weight:: 292.37

MDL Number:: MFCD16619220

MOL File:: 101187-40-0.mol

Last updated:2025-11-16 10:30:15

Product description	Number	Pack Size	Price
N-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt purum, ≥97.0% (TLC)	07185	100mg	$261
Boc-Amino-PEG3-Amine	B6080	250MG	$109
Boc-Amino-PEG3-Amine	B6080	1G	$308
N-Boc-1,11-diamino-3,6,9-trioxaundecane	B659028	500mg	$350
N-Boc-1,11-diamino-3,6,9-trioxaundecane	B659028	100mg	$90
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5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Properties

Boiling point	405.7±35.0 °C(Predicted)
Density	1.050
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Soluble in Water, DMSO, DCM, DMF
form	clear liquid to cloudy liquid
pka	12.23±0.46(Predicted)
color	Colorless to Light yellow to Light orange
InChI	InChI=1S/C13H28N2O5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11,14H2,1-3H3,(H,15,16)
InChIKey	CUPBLDPRUBNAIE-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCCOCCOCCOCCN
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

HS Code

2924190090

NFPA 704

	1
0		0

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	07185	N-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt purum, ≥97.0% (TLC)	101187-40-0	100mg	$261	2023-06-20	Buy
TCI Chemical	B6080	Boc-Amino-PEG3-Amine	101187-40-0	250MG	$109	2025-07-31	Buy
TCI Chemical	B6080	Boc-Amino-PEG3-Amine	101187-40-0	1G	$308	2025-07-31	Buy
TRC	B659028	N-Boc-1,11-diamino-3,6,9-trioxaundecane	101187-40-0	500mg	$350	2021-12-16	Buy
TRC	B659028	N-Boc-1,11-diamino-3,6,9-trioxaundecane	101187-40-0	100mg	$90	2021-12-16	Buy

Product number	Packaging	Price	Buy
07185	100mg	$261	Buy
B6080	250MG	$109	Buy
B6080	1G	$308	Buy
B659028	500mg	$350	Buy
B659028	100mg	$90	Buy

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Chemical Properties,Uses,Production

Uses

N-Boc-1,11-Diamino-3,6,9-trioxaundecane is a useful research chemical.

Description

t-Boc-N-Amido-PEG3-amine is a PEG linker with an amino group and Boc-protected amino. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to free the amine.

Chemical Properties

Colorless viscous liquid

Synthesis

929-75-9

24424-99-5

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

101187-40-0

General procedure: 3,6,9-Trioxaundecane-1,11-diamine (1 eq.) was dissolved in dichloromethane (DCM, 10 mL/mmol), and di-tert-butyl dicarbonate (Boc2O, 0.15 eq.) was slowly added at 0 °C. The reaction mixture was stirred at 0°C for 5 hours, then brought to room temperature and continued stirring for 18 hours. Upon completion of the reaction, the organic phase was washed several times with water to remove unreacted 3,6,9-trioxaundecane-1,11-diamine. The organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to quantitatively yield the Boc-protected product (tert-butyl 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate. 1H NMR (300 MHz, CDCl3) data for product 11a: δ 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2). 1H NMR (300 MHz, CDCl3) data for product 11b: δ 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2). NHCO2).

References

[1] Tetrahedron, 2012, vol. 68, # 52, p. 10818 - 10826
[2] Journal of the American Chemical Society, 2001, vol. 123, # 37, p. 8914 - 8922
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 3, p. 625 - 637
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 6, p. 853 - 856
[5] Journal of the American Chemical Society, 2015, vol. 137, # 28, p. 9108 - 9116

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester synthesis

Synthesis of 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester from 3,6,9-trioxaundecamethylenediamine and Di-tert-butyl dicarbonate

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Azido-PEG4-NHBoc 3,6,9-trioxaundecamethylenediamine Di-tert-butyl dicarbonate Trimethylacetic anhydride

Preparation Products

N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Suppliers

Global( 201)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	458	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20138	58
LAURENT	+undefined18100176782	sun@laurentpeg.com	China	364	58
Adachibio Inc.	+81-8027837258; +8108027837258	sales@adachibio.com	Japan	992	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Suzhou Highfine Biotech Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
LAURENT	58
Adachibio Inc.	58
Springchem New Material Technology Co.,Limited	57
9i LLC	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58

View Lastest Price from 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-27	BocNH-PEG3-CH2CH2NH2 101187-40-0	US $23.52 / g	10g	98%	500kg	LAURENT
2025-09-25	5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester 101187-40-0	US $6.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-09-12	tert-butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate 101187-40-0	US $0.00-0.00 / g	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.

BocNH-PEG3-CH2CH2NH2
101187-40-0
US $23.52 / g
98%
LAURENT

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester
101187-40-0
US $6.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

tert-butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate
101187-40-0
US $0.00-0.00 / g
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Spectrum

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester(101187-40-0)¹HNMR

101187-40-0(5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester)Related Search:

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1of4

t-Boc-N-Amido-PEG3-Amine Boc-N-Amido-PEG3-Amine tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate BOC-NH-PEG3-NH2 tert-Butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate N-Boc-1,11-diamino-3,6,9-trioxaundecane≥ 98% (GC) tert-Boc-N-amido-PEG3-amine N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy} 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester 13-Amino-5,8,11-trioxa-2-azatridecanoic acid 1,1-dimethylethyl ester 5,8,11-Trioxa-2-azatridecanoic acid, 13-aMino-, 1,1-diMethylethyl ester Boc-NH-PEG3-CH2CH2NH2 Amino-PEG4-NHBoc terr-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate BOC-N-AMIDO-PEG3-NH2 t-BocNH-PEG3-CH2CH2NH2 NHBoc-PEG3-amine N-Boc-1,11-diamino-3,6,9-trioxaundecane 1-Boc-amino-11-bromo-3.6.9-trioxadecane N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethylamine, 98% NH2-PEG3-NHBOC NHBoc-PEG4-NH2 N-Boc-2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine 13-AMINO-5,8,11-TRIOXA-2-AZATRIDECANOIC ACID TERT-BUTYL ESTER [2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]carbamic Acid tert-Butyl Ester N-Boc-3,6,9-triox PROTAC Linker 15 N-(tert-Butoxycarbonyl)-3,6,9-trioxa-1,11-undecanediamine 11-Trioxa-2-azatridecanoic 13-amino N-Boc-2-{2-[2-(2-amino-ethoxy)-et （2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate ert-butylN-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate t-Boc-Amido-PEG4-Amine BocNH-PEG3-CH2CH2NH2/5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, 1,1-dimethylethyl ester 1-Boc-amine-11-amino-3,6,9-trioxaundecane 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethyle N-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt 101187-40-0 1011187-40-0 C13H28N2O5 ADCs Linkers peg