ChemicalBook >> CAS DataBase List >>GSK2110183B
GSK2110183B
- CAS No.
- 1047645-82-8
- Chemical Name:
- GSK2110183B
- Synonyms
- GSK2110183B;GSK 2110183B;GSK-2110183B;Afuresertib HCl;GSK2110183 hydrochloride;GSK-2110183 hydrochloride;GSK 2110183 hydrochloride;Afuresertib (hydrochloride);Afuresertib HCl (GSK2110183);Afuresertib hydrochloride GSK2110183
- CBNumber:
- CB02667591
- Molecular Formula:
- C18H18Cl3FN4OS
- Molecular Weight:
- 463.78
- MDL Number:
- MOL File:
- 1047645-82-8.mol
Last updated:2023-06-08 09:02:22
| storage temp. | Store at -20°C, protect from light, stored under nitrogen |
|---|---|
| solubility |
DMSO:65.0(Max Conc. mg/mL);140.15(Max Conc. mM) DMF:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.08(Max Conc. mM) |
| form | A crystalline solid |
| FDA UNII | 0FC27E442O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
GSK2110183B price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17988 | Afuresertib (hydrochloride) ≥98% | 1047645-82-8 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 17988 | Afuresertib (hydrochloride) ≥98% | 1047645-82-8 | 5mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 17988 | Afuresertib (hydrochloride) ≥98% | 1047645-82-8 | 10mg | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 17988 | Afuresertib (hydrochloride) | 1047645-82-8 | 25mg | $583 | 2024-03-01 | Buy |
| ChemScene | CS-3385 | Afuresertib(hydrochloride) 98.02% | 1047645-82-8 | 100mg | $564 | 2021-12-16 | Buy |
GSK2110183B Chemical Properties,Uses,Production
Uses
Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis. Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.[Cayman Chemical]
GSK2110183B Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2110183B Suppliers
Global( 71)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Afuresertib (hydrochloride)
GSK 2110183B
GSK2110183B
GSK-2110183B
GSK 2110183 hydrochloride
GSK2110183 hydrochloride
GSK-2110183 hydrochloride
N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride
Afuresertib HCl
Afuresertib HCl (GSK2110183)
Afuresertib HCl salt, GSK-2110183 HCl salt, GSK-2110183B HCl salt
N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
2-Thiophenecarboxamide, n-[(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1)
AFURESERTIB;GSK 2110183;GSK2110183;GSK 2110183 HYDROCHLORIDE; GSK2110183 HYDROCHLORIDE; GSK-2110183 HYDROCHLORIDE
GSK 2110183 hydrochloride - Afuresertib hydrochloride
(S)-N-(1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride
Afuresertib hydrochloride GSK2110183
Afuresertib,PKC,Protein kinase C,Akt,PKB,Rho-kinase,GSK2110183,ROK,Rho-associated protein kinase,Inhibitor,GSK-2110183,inhibit,Protein kinase B,Afuresertib hydrochloride,Rho-associated kinase,GSK 2110183,ROCK
(S)-N-(1-amino-3- (3-fluorophenyl) propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl) thiophene-2-formamide, hydrochloride
1047645-82-8
C18H17Cl2FN4OSClH