RI-2
- CAS No.
- 1417162-36-7
- Chemical Name:
- RI-2
- Synonyms
- RI-2;CS-1675;RI2;RI 2;Inhibitor,RI 2,RAD51,inhibit,RI2,RI-2;1-(3,4-Dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-
- CBNumber:
- CB02744881
- Molecular Formula:
- C21H18Cl2N2O4
- Molecular Weight:
- 433.28
- MDL Number:
- MOL File:
- 1417162-36-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
RI-2 price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18397 | RI-2 ≥98% | 1417162-36-7 | 1mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 18397 | RI-2 ≥98% | 1417162-36-7 | 5mg | $249 | 2024-03-01 | Buy |
Cayman Chemical | 18397 | RI-2 ≥98% | 1417162-36-7 | 10mg | $437 | 2024-03-01 | Buy |
Cayman Chemical | 18397 | RI-2 ≥98% | 1417162-36-7 | 50mg | $1092 | 2024-03-01 | Buy |
ChemScene | CS-4307 | RI-2 99.22% | 1417162-36-7 | 50mg | $900 | 2021-12-16 | Buy |
RI-2 Chemical Properties,Uses,Production
Description
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-
Uses
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.[Cayman Chemical]
in vitro
although ri-2 did exhibit reduced activity relative to ri-1, it did retain enough activity to sensitize cells to mmc cell-based assays. ri-2 exhibited no reactivity toward glutathione after incubation for 24 hours. rad51 protein that had been treated with ri-2 prior to washing exhibited no measurable loss of dna binding activity, even though ri-2 is known to inhibit rad51 with an ic50 of 44.17 μm. this indicates that rad51 inhibition by ri-2 is fully reversible [1].
in vivo
ri-1, the analogue of ri-2, facilitated mapping of the binding pocket within known crystal structures of rad51. however, this reactivity of ri-1 potentially may limit its development in pre-clinical animal models. ri-1 has been found to exhibit a relatively short half-life, due to reactivity in thiol-containing solutions [1].
IC 50
44.17 μm
References
[1] budke b, kalin jh, pawlowski m, zelivianskaia as, wu m, kozikowski ap, connell pp. an optimized rad51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity. j med chem. 2013 jan 10;56(1):254-63.
RI-2 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4121 | 55 |