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Trifluoroacetamide

CAS No.
354-38-1
Chemical Name:
Trifluoroacetamide
Synonyms
2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Trifluoroacetamide98%;Three fluoroacetaMide;2,2,2-Trifluoracetamid
CBNumber:
CB0291820
Molecular Formula:
C2H2F3NO
Molecular Weight:
113.04
MDL Number:
MFCD00008008
MOL File:
354-38-1.mol
MSDS File:
SDS
Last updated:2023-10-30 17:09:20

Trifluoroacetamide Properties

Melting point 65-70 °C (lit.)
Boiling point 162.5 °C (lit.)
Density 1.4176 (estimate)
Flash point 162-164°C
storage temp. Store below +30°C.
solubility 460 g/L (20°C)
form Crystalline Powder or Crystals
pka 12.33±0.50(Predicted)
color White to pale yellow or beige
PH 3.6 (460g/l, H2O, 23℃)
Water Solubility 460 g/L (20 ºC)
BRN 1753625
InChIKey NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP 0.725 at 23℃ and pH4.83
Dissociation constant 0 at 23℃
CAS DataBase Reference 354-38-1(CAS DataBase Reference)
FDA UNII 36MU16BYFK
NIST Chemistry Reference Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System Acetamide, 2,2,2-trifluoro- (354-38-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
RIDADR  1759
WGK Germany  3
Hazard Note  Harmful/Irritant
TSCA  T
HazardClass  8
PackingGroup  III
HS Code  29241900
NFPA 704
1
2

Trifluoroacetamide price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14690 2,2,2-Trifluoroacetamide for synthesis 354-38-1 10G $37 2024-03-01 Buy
Sigma-Aldrich 8.14690 2,2,2-Trifluoroacetamide for synthesis 354-38-1 50G $128 2024-03-01 Buy
Sigma-Aldrich 144657 Trifluoroacetamide 97% 354-38-1 25g $42.1 2024-03-01 Buy
Sigma-Aldrich 144657 Trifluoroacetamide 97% 354-38-1 100g $111 2024-03-01 Buy
TCI Chemical T0598 Trifluoroacetamide >98.0%(GC) 354-38-1 25g $20 2024-03-01 Buy
Product number Packaging Price Buy
8.14690 10G $37 Buy
8.14690 50G $128 Buy
144657 25g $42.1 Buy
144657 100g $111 Buy
T0598 25g $20 Buy

Trifluoroacetamide Chemical Properties,Uses,Production

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

383-63-1
354-38-1
Synthesis of Trifluoroacetamide from Ethyl trifluoroacetate
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View Lastest Price from Trifluoroacetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trifluoroacetamide pictures 2023-10-30 Trifluoroacetamide
354-38-1
US $50.00-40.00 / kg 1kg 99% 100 tons Anhui Yiao New Material Technology Co., Ltd
Trifluoroacetamide pictures 2023-10-30 Trifluoroacetamide
354-38-1
US $50.00-40.00 / kg 1kg 99% 100 tons Anhui Yiao New Material Technology Co., Ltd
Trifluoroacetamide pictures 2023-10-30 Trifluoroacetamide
354-38-1
US $50.00-40.00 / kg 1kg 99% 100 tons Anhui Yiao New Material Technology Co., Ltd
  • Trifluoroacetamide pictures
  • Trifluoroacetamide
    354-38-1
  • US $50.00-40.00 / kg
  • 99%
  • Anhui Yiao New Material Technology Co., Ltd
  • Trifluoroacetamide pictures
  • Trifluoroacetamide
    354-38-1
  • US $50.00-40.00 / kg
  • 99%
  • Anhui Yiao New Material Technology Co., Ltd
  • Trifluoroacetamide pictures
  • Trifluoroacetamide
    354-38-1
  • US $50.00-40.00 / kg
  • 99%
  • Anhui Yiao New Material Technology Co., Ltd
Three fluoroacetaMide TRIFLUOROACETAMIDE TRIFLUOROACETIC ACID AMIDE 2,2,2-trifluoro-acetamid TRIFLUOROACETAMIDE 98% 2,2,2-TRIFLOUROACETAMIDE 2,2,2-TRIFLOUROACET-AMIDE (TFAA) Trifluoroacetamide98% 2,2,2-TRIFLOUROACET-AMIDE TFAA 98+% 2,2,2-Trifluoroacetamide (TFAA) 2,2,2-Trifluoroacetamide ,99% 2,2,2-Trifluoroacetamide,97% 2,2,2-trifluoroacetanide 2-TriflouroacetaMide 2,2,2-TRIFLUOROACETAMIDE FOR SYNTHESIS Three- Factory Supply Trifluoroacetamid E CAS?354-38-1?with Best Price 2,2,4-Trifluoroacetamide, 97%+ 2,2,4-Trifluoroacetamide 2,2,2-TRIFLUOROACETAMIDE CF3CONH2 Triflouroacetamide Acetamide, 2,2,2-trifluoro- 2,2,2-Trifluoracetamid 354-38-1 C2H2F3NO CF3CONH3 Organic Building Blocks Carbonyl Compounds Amides Building Blocks Amides Carbonyl Compounds Organic Building Blocks top bc0001