TMS
- CAS No.
- 24144-92-1
- Chemical Name:
- TMS
- Synonyms
- CS-961;SMB 00388;TMS, >=98%;TMS, 10 mM in DMSO;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;2,4,3',5'-Tetramethoxystilbene;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS (2,4,3',5'-tetramethoxystilbene)
- CBNumber:
- CB0347220
- Molecular Formula:
- C18H20O4
- Molecular Weight:
- 300.35
- MDL Number:
- MFCD03428621
- MOL File:
- 24144-92-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 78-79 °C |
|---|---|
| Boiling point | 459.9±40.0 °C(Predicted) |
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml |
| form | Powder |
| color | Light yellow to yellow |
| InChI | 1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+ |
| InChIKey | JDBCWSHYEQUBLW-AATRIKPKSA-N |
| SMILES | COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2 |
| UNSPSC Code | 85151701 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
TMS price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00388 | 2,4,3′,5′-tetramethoxystilbene ≥98% (HPLC) | 24144-92-1 | 10 mg | $173 | 2026-04-30 | Buy |
| Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 1mg | $18 | 2026-04-30 | Buy |
| Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 5mg | $70 | 2026-04-30 | Buy |
| Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 10mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 50mg | $516 | 2026-04-30 | Buy |
TMS Chemical Properties, Uses, Production
Uses
2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Uses
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.
Uses
2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Definition
ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.
Biological Activity
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .
in vivo
To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) [1].
IC 50
CYP1B1: 6 nM (IC50); CYP1B1: 3 nM (Ki); CYP1A1: 300 nM (IC50); CYP1A2: 3.1 μM (IC50)
TMS Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Suweike New Materials Co., Ltd | 18896959461 | efp409@163.com | China | 500 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
View Latest Price from TMS manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-02 | 2,4,3',5'-tetramethoxystilbene
24144-92-1
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
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- 2,4,3',5'-tetramethoxystilbene
24144-92-1
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
