TMS
- CAS No.
- 24144-92-1
- Chemical Name:
- TMS
- Synonyms
- CS-961;SMB 00388;TMS, >=98%;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS - Trans-2,3',4,5'-tetramethoxystilbene;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
- CBNumber:
- CB0347220
- Molecular Formula:
- C18H20O4
- Molecular Weight:
- 300.35
- MDL Number:
- MFCD03428621
- MOL File:
- 24144-92-1.mol
- MSDS File:
- SDS
Melting point | 78-79 °C |
---|---|
Boiling point | 459.9±40.0 °C(Predicted) |
Density | 1.117±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml |
form | Powder |
color | Light yellow to yellow |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
NFPA 704 |
|
TMS price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 1mg | $16 | 2024-03-01 | Buy |
Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 5mg | $63 | 2024-03-01 | Buy |
Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 10038 | TMS ≥98% | 24144-92-1 | 50mg | $469 | 2024-03-01 | Buy |
TRC | T298900 | 2,4,3'',5''-Tetramethoxystilbene | 24144-92-1 | 1g | $1695 | 2021-12-16 | Buy |
TMS Chemical Properties,Uses,Production
Uses
2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Uses
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.
Uses
2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Definition
ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.
Biological Activity
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .
TMS Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from TMS manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-02 | 2,4,3',5'-tetramethoxystilbene
24144-92-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
- 2,4,3',5'-tetramethoxystilbene
24144-92-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
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