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BAPTA-AM

Description
BAPTA-AM
BAPTA-AM structure
CAS No.
126150-97-8
Chemical Name:
BAPTA-AM
Synonyms
DAPTA-AM;BAPTA-AM;BAPTA AM, >=98%;BAPTA/AM(BAPTA-AM);BAPTA, AM *CAS 126150-97-8*;BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER;Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate;1,2-BIS (2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID, TETRAACETOXYMETHYL ESTER;1,2-BIS(O-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID TETRA(ACETOXYMETHYL) ESTER
CBNumber:
CB0461324
Molecular Formula:
C34H40N2O18
Formula Weight:
764.68
MOL File:
126150-97-8.mol

BAPTA-AM Properties

Melting point:
86-90°C
storage temp. 
−20°C
solubility 
Soluble in chloroform, dimethyl sulfoxide
form 
powder
color 
White
λmax
287 nm
BRN 
7458534
Stability:
Light Sensitive
Biological Applications
Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions
InChIKey
YJIYWYAMZFVECX-UHFFFAOYSA-N
CAS DataBase Reference
126150-97-8(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
8-10-21

BAPTA-AM price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A1076 BAPTA-AM ≥95% (HPLC) 126150-97-8 25mg $219 2018-11-13 Buy
Cayman Chemical 15551 BAPTA AM ≥98% 126150-97-8 5mg $35 2018-11-13 Buy
Cayman Chemical 15551 BAPTA AM ≥98% 126150-97-8 10mg $63 2018-11-13 Buy
Cayman Chemical 15551 BAPTA AM ≥98% 126150-97-8 25mg $96 2018-11-13 Buy
Cayman Chemical 15551 BAPTA AM ≥98% 126150-97-8 100mg $350 2018-11-13 Buy

BAPTA-AM Chemical Properties,Uses,Production

Description

BAPTA-AM is a selective, membrane-permeable calcium chelator.

Chemical Properties

Off-White to Light Yellow Solid

Uses

BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Uses

A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.

Uses

BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).

Uses

A cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786 ). Blocks hK v 1.5, hERG and hK v 1.3 channels (K i values are 1.23, 1.30 and 1.45 μ M respectively). Displays antithrombotic activity in vitro .

BAPTA-AM Preparation Products And Raw materials

Raw materials

Preparation Products


BAPTA-AM Suppliers

Global( 120)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63729 58
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 QQ:452520369
+86 (573) 82222643 sales@maya-r.com China 11740 57
Hefei NaNo Biological Technology Co., Ltd. 18010855303 0551-65629887
0551-65629887 sales@hfnhsw.com China 259 58
Shanghai Race Chemical Co., Ltd. 86-021-54933292
86-021-54933292 sales@racechemical.com China 239 50
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81

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