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DI-TERT-BUTYL IMINODIACETATE

DI-TERT-BUTYL IMINODIACETATE structure

CAS No.: 85916-13-8

Chemical Name:: DI-TERT-BUTYL IMINODIACETATE

Synonyms: NH-bis(C1-Boc);N-BIS(T-BUTYLACETATE)AMINE;DI-TERT-BUTYL IMINODIACETATE;DL-tert-Butyl Iminodiacetate;Di-tert-butylIminodiacetate>Di-tert-butyl iminodiacetate 98%;di-tert-butyl 2,2'-iminodiacetate;Di-tert-butyl Iminodiacetate;Di-tert-butyl 2,2'-iminobis[acetate];Di-tert-butyl iminodiacetate≥ 98%(GC)

CBNumber:: CB0738891

Molecular Formula:: C12H23NO4

Molecular Weight:: 245.32

MDL Number:: MFCD01863672

MOL File:: 85916-13-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

Product description	Number	Pack Size	Price
Di-tert-butyl iminodiacetate 98%	511323	1g	$59.47
Di-tert-butyl iminodiacetate 98%	511323	5g	$225.28
Di-tert-butyl Iminodiacetate >97.0%(GC)	D4109	1g	$57
Di-tert-butyl Iminodiacetate >97.0%(GC)	D4109	5g	$186
DL-tert-ButylIminodiacetate	D492920	500mg	$110
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DI-TERT-BUTYL IMINODIACETATE Properties

Melting point	38-42 °C(lit.)
Boiling point	298.0±25.0 °C(Predicted)
Density	1.011±0.06 g/cm3(Predicted)
Flash point	>230 °F
storage temp.	2-8°C(protect from light)
solubility	Methanol[soluble in]
solubility	soluble in Methanol
form	powder to lump to clear liquid
pka	4.52±0.20(Predicted)
color	White or Colorless to Almost white or Almost colorless
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

WGK Germany

HS Code

29224999

NFPA 704

	0
2		0

DI-TERT-BUTYL IMINODIACETATE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	511323	Di-tert-butyl iminodiacetate 98%	85916-13-8	1g	$59.47	2025-07-31	Buy
Sigma-Aldrich	511323	Di-tert-butyl iminodiacetate 98%	85916-13-8	5g	$225.28	2025-07-31	Buy
TCI Chemical	D4109	Di-tert-butyl Iminodiacetate >97.0%(GC)	85916-13-8	1g	$57	2025-07-31	Buy
TCI Chemical	D4109	Di-tert-butyl Iminodiacetate >97.0%(GC)	85916-13-8	5g	$186	2025-07-31	Buy
TRC	D492920	DL-tert-ButylIminodiacetate	85916-13-8	500mg	$110	2021-12-16	Buy

Product number	Packaging	Price	Buy
511323	1g	$59.47	Buy
511323	5g	$225.28	Buy
D4109	1g	$57	Buy
D4109	5g	$186	Buy
D492920	500mg	$110	Buy

DI-TERT-BUTYL IMINODIACETATE Chemical Properties,Uses,Production

Chemical Properties

White to tan solid

Uses

Di-tert-butyl iminodiacetate may be used as a reagent in the synthesis of:

multi-carboxylic acid-containing carbocyanine dyes
monosubstituted difunctionalized polyhedral oligomeric silsesquioxanes (POSS) monomers
multigenerational fluorinated dendrimers
2,6-dipyrazol-1-ylpyridine derivatives

It may also be used for the preparation of di-tert-butyl N-(4-allyloxy-4-oxobutanoyl)iminodiacetate.

General Description

Di-tert-butyl iminodiacetate is a secondary amine.

Synthesis

107-59-5

85916-13-8

The general procedure for the synthesis of di-tert-butyl iminodiacetate from tert-butyl chloroacetate is as follows: in a 250 mL three-necked flask equipped with a thermometer, condenser tube and mechanical stirring device, 120 mL of methanol was added. Under continuous stirring, 120.0 g of tert-butyl chloroacetate (0.8 mol) was heated to 65 °C and 5.1 g of ammonia (0.3 mol) was slowly passed through. The reaction was carried out for 2 hours and then continued to hold the reaction for 5 hours. After the reaction mixture was cooled to room temperature, it was filtered to remove the resulting white solid ammonium chloride. The filtrate was concentrated by rotary evaporation to recover about 110 mL of methanol. The concentrated residue was cooled to 0 °C to induce precipitation of the product. The precipitate was collected by filtration to give 23.3 g of di-tert-butyl iminodiacetate with a melting point of 41 °C.

IC 50

Non-cleavable Linker

References

[1] Patent: CN108191686, 2018, A. Location in patent: Paragraph 0040-0073

DI-TERT-BUTYL IMINODIACETATE Preparation Products And Raw materials

Raw materials

tert-Butyl chloroacetate Glycine, N-[2-(1,1-dimethylethoxy)-2-oxoethyl]-N-(phenylmethyl)-, 1,1-dimethylethyl ester Ammonia Methanol

Preparation Products

DI-TERT-BUTYL IMINODIACETATE Suppliers

Global( 107)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20137	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8460	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Alchem Pharmtech,Inc.	58
Antai Fine Chemical Technology Co.,Limited	58
TargetMol Chemicals Inc.	58
Shanghai UCHEM Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou Huarong Pharm Co., Ltd.	58

View Lastest Price from DI-TERT-BUTYL IMINODIACETATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-25	DI-TERT-BUTYL IMINODIACETATE 85916-13-8	US $34.00-1.20 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
	2019-09-02	DI-TERT-BUTYL IMINODIACETATE 85916-13-8	US $1.00 / KG	1KG	≥98%	200KG	Career Henan Chemical Co

DI-TERT-BUTYL IMINODIACETATE
85916-13-8
US $34.00-1.20 / kg
99%
Henan Fengda Chemical Co., Ltd

DI-TERT-BUTYL IMINODIACETATE
85916-13-8
US $1.00 / KG
≥98%
Career Henan Chemical Co

DI-TERT-BUTYL IMINODIACETATE Spectrum

DI-TERT-BUTYL IMINODIACETATE(85916-13-8)¹HNMR DI-TERT-BUTYL IMINODIACETATE(85916-13-8)IR

85916-13-8(DI-TERT-BUTYL IMINODIACETATE)Related Search:

Diethyl iminodiacetate diisobutyl terephthalate ISOBUTYL P-TOLUENESULFONATE DIISOBUTYL PHOSPHITE Pinacol vinylboronate

Iminodiacetic acid Iminodibenzyl Iminodiacetonitrile DI-TERT-BUTYL IMINODIACETATE N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL

4-(N-BOC-AMINOXYACETAMIDO)BENZYL ETHYLENEDIAMINETETRAACETIC ACID, TETRA(T-BUTYL) ESTER N-[2-[2-[2-[BIS[2-(1,1-DIMETHYLETHOXY)-2-OXOETHYL]AMINO]-5-METHYLPHENOXY]ETHOXY]PHENYL]-N-[2-(1,1-DIMETHYLETHOXY)-2-OXOETHYL]-GLYCINE 1,1-DIMETHYLETHYL ESTER N-[2-[2-[2-[BIS[2-(1,1-DIMETHYLETHOXY)-2-OXOETHYL]AMINO]-5-BROMOPHENOXY]ETHOXY]-4-METHYLPHENYL]-N-[2-(1,1-DIMETHYLETHOXY)-2-OXOETHYL]-GLYCINE TERT-BUTYL ESTER (BIS-TERT-BUTOXYCARBONYLMETHYL-AMINO)-ACETIC ACID 3-BENZYLSULFANYL-2-(TERT-BUTOXYCARBONYLMETHYL-AMINO)-PROPIONIC ACID TERT-BUTYL ESTER

N-(5-AMino-1-carboxypentyl)iMinodiacetic Acid Tri-t-butyl Ester DI-TERT-BUTYL-2-BROMOETHYLIMINODIACETATE [[(S)-2-(BIS-TERT-BUTOXYCARBONYLMETHYL-AMINO)-PROPYL]-(TOLUENE-4-SULFONYL)-AMINO]-ACETIC ACID TERT-BUTYL ESTER

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DI-TERT-BUTYL IMINODIACETATE Iminodiacetic Acid Di-tert-butyl Ester Di-tert-butyl 2,2'-azanediyldiacetate (tert-Butoxycarbonylmethylamino)acetic acid tert-butyl ester Di-tert-butyl 2,2'-iminobis[acetate] Di-tert-butyl iminodiacetate 98% Di-tert-butyl Iminodiacetate Di-tert-butyl iminodiacetate≥ 98%(GC) N-BIS(T-BUTYLACETATE)AMINE di-tert-butyl 2,2'-iminodiacetate Di-tert-butylIminodiacetate> NH-bis(C1-Boc) Glycine, N-[2-(1,1-dimethylethoxy)-2-oxoethyl]-, 1,1-dimethylethyl ester DL-tert-Butyl Iminodiacetate antibody-drug conjugate,NH bis(C1 Boc),NH-bis(C-1-Boc),Linker,ADC,inhibit,Inhibitor,NHbis(C1Boc),Antibody-drug conjugates linkers,ADC Linkers tert-butyl 2-[[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]acetate 85916-13-8 HNCH2CO2CCH332 IMINE Esters Organic Building Blocks Carbonyl Compounds C12 to C63 Building Blocks Building Blocks C12 to C63 Carbonyl Compounds Chemical Synthesis Organic Building Blocks C12 to C63 Carbonyl Compounds Esters