Clobutinol
- CAS No.
- 14860-49-2
- Chemical Name:
- Clobutinol
- Synonyms
- Clobutinol USP/EP/BP;Clobutinol (base and/or unspecified salts);2-(p-Chlorobenzyl)-3-dimethylaminomethyl-2-butano;1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol;1-(p-Chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol;1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol;1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-butan-2-ol;Benzeneethanol, 4-chloro-α-[2-(dimethylamino)-1-methylethyl]-α-methyl-;4-Chloro-α-methyl-α-[2-(dimethylamino)-1-methylethyl]phenethyl alcohol;4-Chloro-α-[2-(dimethylamino)-1-methylethyl]-α-methylphenethyl alcohol
- CBNumber:
- CB0875028
- Molecular Formula:
- C14H22ClNO
- Molecular Weight:
- 255.78
- MDL Number:
- MOL File:
- 14860-49-2.mol
| Boiling point | bp12 179-180° |
|---|---|
| Density | 1.0373 (rough estimate) |
| refractive index | 1.6330 (estimate) |
| pka | 14.63±0.29(Predicted) |
| FDA UNII | 1NY2IX043A |
Clobutinol Chemical Properties,Uses,Production
Originator
Silomat,Boehringer Ingelheim,Switz.,1960
Definition
ChEBI: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol is an organic amino compound and a member of benzenes.
Manufacturing Process
A solution of 0.2 mol (33 g) of 3-methyl-4-dimethylamino-butanone-(2)
[produced according to Mannich, Arch. Pharm., vol. 265, page 589 (1927)] in
50 cc absolute ether was added dropwise, while stirring and cooling with ice,
to a Grignard solution of 0.4 mol p-chlorobenzylmagnesium-chloride which
was produced from 64.5 g p-chlorobenzyl-chloride and 9.8 g magnesium in
200 cc absolute ether. The reaction product was heated for an additional onehalf hour under reflux to bring the reaction to completion, and thereafter the
reaction mixture was decomposed into an ether phase and an aqueous phase
with about 50 cc concentrated hydrochloric acid and about 200 g ice. The
ether phase was discarded and the aqueous phase was adjusted to an alkaline
pH with ammonia and then thoroughly extracted with ether. After
concentrating the united, dried ether extract solutions, the oily residue was
fractionally distilled. The reaction product was obtained in the form of a
colorless oil having a boiling point of 179° to 181°C. The yield was 48.5 g
corresponding to 95% of theory.
The hydrochloride addition salt of the above reaction product was prepared in
customary fashion, that is, by reaction with hydrochloric acid, followed by
fractional crystallization from a mixture of alcohol and ether. The two possible
racemic forms were obtained thereby. The difficultly soluble racemate had a
melting point of 169° to 170°C and the more readily soluble racemate had a
boiling point of 145° to 148°C.
Therapeutic Function
Antitussive
Clobutinol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3422 | 58 |
| Shanghai kingmorn biotechnology Co.,Ltd. | 021-62200788 15000569291 | 2199306478@qq.com | CHINA | 100 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| Wuhan pengyin Pharmaceutical Co., Ltd | 13163333255 | 1939328613@qq.com | China | 395 | 58 |
| Hebei Zhenjia new material Co., LTD | 0319-5925599 13315915972 | 13313090628@163.com | China | 3489 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |
View Lastest Price from Clobutinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-16 | Clobutinol
14860-49-2
|
US $0.00-0.00 / KG | 1KG | 98% | >10kg | Shanghai kingmorn biotechnology Co.,LTD. | |
 |
2020-04-25 | Clobutinol
14860-49-2
|
US $0.01-1.00 / KG | 1KG | 99% | 50 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Clobutinol
14860-49-2
- US $0.00-0.00 / KG
- 98%
- Shanghai kingmorn biotechnology Co.,LTD.
-
- Clobutinol
14860-49-2
- US $0.01-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd