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Phenethyl alcohol

Edible spices Reference quality standards Content Analysis toxicity Limited use Chemical property Uses Category Toxicity classification Acute toxity Stimulate data Flammability hazard characteristics Transportation and storing characteristics Extinguishing agent
Phenethyl alcohol
Phenethyl alcohol structure
CAS No.
60-12-8
Chemical Name:
Phenethyl alcohol
Synonyms
2-PEA;Mellol;beta-PEA;FEMA 2858;(beta-pea);NSC 406252;Phenethanol;beta-P.E.A.;2-Phenethanol;β-Phenethylol
CBNumber:
CB5145283
Molecular Formula:
C8H10O
Formula Weight:
122.16
MOL File:
60-12-8.mol

Phenethyl alcohol Properties

Melting point:
−27 °C(lit.)
Boiling point:
219-221 °C750 mm Hg(lit.)
Density 
1.020 g/mL at 20 °C(lit.)
vapor density 
4.21 (vs air)
vapor pressure 
1 mm Hg ( 58 °C)
refractive index 
n20/D 1.5317(lit.)
FEMA 
2858 | PHENETHYL ALCOHOL
Flash point:
216 °F
storage temp. 
Store at RT.
solubility 
Miscible with chloroform.
form 
Liquid
color 
Clear colorless
PH
6-7 (20g/l, H2O, 20℃)
explosive limit
1.4-11.9%(V)
Water Solubility 
20 g/L (20 ºC)
Merck 
14,7224
JECFA Number
987
BRN 
1905732
Stability:
Stable. Substances to be avoided include strong acids and strong oxidizing agents. Combustible.
InChIKey
WRMNZCZEMHIOCP-UHFFFAOYSA-N
CAS DataBase Reference
60-12-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneethanol(60-12-8)
EPA Substance Registry System
Benzeneethanol(60-12-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn
Risk Statements  21/22-36/38-36-22
Safety Statements  26-28-36/37-36/37/39
RIDADR  UN 2810 6.1/PG 3
WGK Germany  1
RTECS  SG7175000
Autoignition Temperature 410 °C
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29062990
Hazardous Substances Data 60-12-8(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1790 mg/kg (Jenner)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Phenethyl alcohol price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 77861 2-Phenylethanol ≥99.0% (GC) 60-12-8 1l $97.7 2018-11-13 Buy
Sigma-Aldrich 1533250 Phenylethyl alcohol United States Pharmacopeia (USP) Reference Standard 60-12-8 1ml $352.8 2018-11-20 Buy
TCI Chemical P0084 2-Phenylethyl Alcohol >98.0%(GC) 60-12-8 25mL $15 2018-11-22 Buy
TCI Chemical P0084 2-Phenylethyl Alcohol >98.0%(GC) 60-12-8 500mL $34 2018-11-22 Buy
Alfa Aesar A15241 2-Phenylethanol, 98+% 60-12-8 250g $31.2 2018-11-13 Buy

Phenethyl alcohol Chemical Properties,Uses,Production

Edible spices

Phenethyl alcohol is a kind of edible spices, and naturally exists in neroli, rose oil, geranium oil and other oils, because it has a soft, pleasant and persistent rose fragrance and is widely used in various kinds of flavors and cigarette flavor. It is dispensing rose scent, food additives, the main raw material for rose scent flavor, stable on alkali, which are widely used in soap fragrance, is essence blending all rose scent series of spices, because it does not dissolve in water, it is often used in the making up water, soap and orange flower, purple, etc. It is also used in the blending of flavor. Because the phenethyl alcohol has a good antibacterial efficiency, it can be used in the ophthalmic solution. At present there are main three synthesis methods as following:
1, by styrene via halogenation, saponification, hydrogenation, distillation.
2, and microorganism fermentation in yeast by bioconversion.
3, calcium carbide, benzene as raw material preparation of benzyl ethanol, reaction equations are as follows:
1)CaC2+2H2O=Ca(OH)2+C2H2
2)C6H6+C2H2=C6H6CHCH2(Styrene)
3)C6H6CHCH2+H2O=C6H6CH2CH2OH(Phenethyl alcohol)

Reference quality standards

1. appearance: colorless transparent liquid, colour and lustre is not more than 4 # color code
2. aroma: rose aroma
3. relative density (25/25 ℃) : 1.017 to 1.020
4. refractive index (20 ℃) : 1.5310 to 1.5340
5. solubility (25 ℃) : 1 ml sample completely dissolved in 2 ml50 % ethanol, soluble in 50 times the volume of distilled water is clear solution
6. alcohol content: 99.0% (99.5% or higher internal control chemical method, chromatography peaks above 99.7%)
7. chloride content test: pass
8. arsenic content: 3 PPM or less (0.0003%).
9. heavy metals: 10 PPM or less (0.001%)
USP23 version of standard and food additives standard QB/T3786-99 countries
The above information is edited by the chemicalbook of Duan Yalan.

Content Analysis

According to the total amount of alcohol assay (OT-5). Taken by acetylation sample quantity is 1 g. Calculation of the equivalent factor (e) 61.08.

toxicity

LD50 (1580~2020) of 1790 mg/kg (rats, through the mouth).

Limited use

FEMA (mg/kg) : soft drinks; 1.5 Cold drink 8.3; Candy 12; Baked goods 16; The pudding class 0.15; Gum 21~80.

Chemical property

Colorless liquid with rose fragrance. Soluble in ethanol, ethyl ether, glycerin, slightly soluble in water, slightly soluble in mineral oil.

Uses

Phenethyl alcohol is China's regulation edible spice, dosage according to the normal production needs. Generally in 13 sweet sugar 21 to 80 mg/kg; Baked goods in 16 mg/kg; Candy in 12 mg/kg; Cold drinks in 8.3 mg/kg.
GB 2760-1996 rules to allow the use of edible spices. To make honey, bread, peaches and berries such as type of essence.
Allocate rose scent flower essential oil and a variety of floral fragrance, such as jasmine scent, clove, orange flower scent, scent can allocate almost all of the essential oils, widely used in the deployment of soap and cosmetics fragrance. In addition, also can mix all kinds of edible flavor, such as strawberry, peach, plum, melon, caramel, honey is sweet, cream type edible flavor, etc.

Category

Inflammable Liquid

Toxicity classification

Poisoning

Acute toxity

Oral-LD50 in rats: 1790 mg/kg

Stimulate data

Skin-moderate rabbit 100 mg/24 hours; Severe eye-rabbit 0.75 mg/24 hours

Flammability hazard characteristics

Flammable. Combustion produces stimulation of smoke.

Transportation and storing characteristics

Warehouse ventilation, dry at low temperature.

Extinguishing agent

Dry powder, foam, sandy soil, and water

Chemical Properties

colourless liquid

Chemical Properties

Phenylethyl alcohol is a clear, colorless liquid with an odor of rose oil. It has a burning taste that irritates and then anesthetizes mucous membranes.

Chemical Properties

Phenethyl alcohol is the main component of rose oils obtained from rose blossoms. It occurs in smaller quantities in neroli oil, ylang-ylang oil, carnation oil, and geranium oils. Since the alcohol is rather soluble in water, losses occur when essential oils are produced by steam distillation.
Properties. Phenylethyl alcohol is a colorless liquid with a mild rose odor. It can be dehydrogenated catalytically to phenylacetaldehyde and oxidized to phenylacetic acid (e.g.,with chromic acid). Its fatty acid esterswith lowermolecularmass, as well as some alkyl ethers, are valuable fragrance and flavor substances.
Production. Many syntheticmethods are known for preparing phenylethyl alcohol; the following are currently of industrial importance: 1) Friedel–Crafts reaction of benzene and ethylene oxide: In the presence of molar quantities of aluminum chloride, ethylene oxide reacts with benzene to give an addition product, which is hydrolyzed to phenylethyl alcohol:
Formation of by-products, such as 1,2-diphenylethane, is largely avoided by using an excess of benzene at low temperature. Special purification procedures are required to obtain a pure product that is free of chlorine and suitable for use in perfumery.
2) Hydrogenation of styrene oxide: Excellent yields of phenylethyl alcohol are obtainedwhen styrene oxide is hydrogenated at low temperature, using Raney nickel as a catalyst and a small amount of sodium hydroxide.
Uses. Phenylethyl alcohol is used frequently and in large amounts as a fragrance material. It is a popular component in rose-type compositions, but it is also used in other blossom notes. It is stable to alkali and, therefore, ideally suited for use in soap perfumes.

Chemical Properties

Phenethyl alcohol has a characteristic rose-like odor and an initially slightly bitter taste, then sweet and reminiscent of peach.

Occurrence

Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.

Uses

phenethyl alcohol is used to mask odor and also as a preservative.

Uses

antibacterial

Uses

Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).

Production Methods

Phenylethyl alcohol is prepared by reduction of ethyl phenylacetate with sodium in absolute alcohol; by hydrogenation of phenylacetaldehyde in the presence of a nickel catalyst; or by addition of ethylene oxide or ethylene chlorohydrin to phenylmagnesium bromide, followed by hydrolysis. Phenylethyl alcohol also occurs naturally in a number of essential oils, especially rose oil.

Preparation

From toluene, benzene or styrene.

Aroma threshold values

Detection: 0.015 ppb to 3.5 ppm; recognition: 1.2 ppm. Aroma characteristics at 1.0%: floral honey, yeasty bready, musty fresh and sweet.

Taste threshold values

Taste characteristics at 20 ppm: mushroom-like, rose floral, sweet, rosy, bready with honey nuances.

Pharmaceutical Applications

Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25–0.5% v/v concentration; it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant.Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur.
LD50 (rabbit, skin): 0.79 g/kg
LD50 (rat, oral): 1.79 g/kg

storage

Phenylethyl alcohol is stable in bulk, but is volatile and sensitive to light and oxidizing agents. It is reasonably stable in both acidic and alkaline solutions. Aqueous solutions may be sterilized by autoclaving. If stored in low-density polyethylene containers, phenylethyl alcohol may be absorbed by the containers. Losses to polypropylene containers have been reported to be insignificant over 12 weeks at 30°C. Sorption to rubber closures is generally small.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

Purification Methods

Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]

Incompatibilities

Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Phenethyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products


Phenethyl alcohol Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21909 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20675 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32451 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1821 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6373 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25795 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23958 58
Hubei Jusheng Technology Co.,Ltd.
8615527864001
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View Lastest Price from Phenethyl alcohol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 Phenethyl alcohol
60-12-8
US $10.00 / KG 25KG 99% 500KG career henan chemical co

Phenethyl alcohol Spectrum


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