Dantrolene
- CAS No.
- 7261-97-4
- Chemical Name:
- Dantrolene
- Synonyms
- C06939;DANTRILENE;Dantrolene (200 mg);Dantrolene (1163140);1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione;1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE;1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione;1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione;1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione;2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
- CBNumber:
- CB0875659
- Molecular Formula:
- C14H10N4O5
- Molecular Weight:
- 314.25
- MDL Number:
- MFCD00867709
- MOL File:
- 7261-97-4.mol
| Melting point | 279-280° |
|---|---|
| Boiling point | 453.94°C (rough estimate) |
| Density | 1.3452 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Sonicated) |
| pka | 7.68±0.10(Predicted) |
| form | Solid |
| color | Yellow to Dark Yellow |
| Stability | Hygroscopic |
| FDA UNII | F64QU97QCR |
| EPA Substance Registry System | Dantrolene (7261-97-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H336 |
| Precautionary statements | P261-P271-P304+P340+P312-P403+P233-P405-P501 |
| HS Code | 2934990002 |
Dantrolene price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2291 | Dantrolene PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial | 7261-97-4 | 500MG | $186 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1163140 | Dantrolene | 7261-97-4 | 200mg | $480 | 2024-03-01 | Buy |
| TRC | D184995 | Dantrolene | 7261-97-4 | 100mg | $215 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009178 | DANTROLENE 95.00% | 7261-97-4 | 1G | $745.5 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 18586 | Dantrolene | 7261-97-4 | 25mg | $1500 | 2021-12-16 | Buy |
Dantrolene Chemical Properties,Uses,Production
Originator
Dantrium,Norwich Eaton ,US,1974
Uses
Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.
Uses
Relaxant (skeletal muscle).
Definition
ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
Manufacturing Process
5-(p-Nitrophenyl)-2-furaldehyde (40.0 grams, 0.2 mol) is dissolved in dimethylformamide. An aqueous solution of 1-aminohydantoin hydrochloride (30.0 grams, 0.2 mol) is added. The solution is chilled and diluted with water. The crude material is collected and recrystallized from aqueous dimethylformamide to yield 10.0 grams (16%). MP 279°-280°C. This compound is then converted to the sodium salt.
brand name
Dantrium (Procter & Gamble).
Therapeutic Function
Muscle relaxant
General Description
Crystals (in aqueous DMF).
Air & Water Reactions
Slightly water soluble. Dantrolene may be sensitive to heat and air .
Reactivity Profile
A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.
Fire Hazard
Flash point data for Dantrolene are not available. Dantrolene is probably combustible.
Dantrolene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
| Hunan Furui Biopharma Technology Co., Ltd. | 15902102743 | shelley@furuipharma.com | China | 425 | 55 |
View Lastest Price from Dantrolene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | Dantrolene
7261-97-4
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
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- Dantrolene
7261-97-4
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co