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2-BROMO-5-HYDROXYBENZALDEHYDE

2-BROMO-5-HYDROXYBENZALDEHYDE structure

CAS No.: 2973-80-0

Chemical Name:: 2-BROMO-5-HYDROXYBENZALDEHYDE

Synonyms: AKOS B020430;Crisaborole-029;ART-CHEM-BB B020430;4-BROMO-3-FORMYLPHENOL;Crisaborole Impurity 32;2-bromo-5-hydroxybenzadehyde;-BROMO-5-HYDROXYBENZALDEHYDE;2-BROMO-5-HYDROXYBENZALDEHYDE;Crisaborole Related Compound 2;Benzaldehyde, 2-bromo-5-hydroxy-

CBNumber:: CB1114360

Molecular Formula:: C7H5BrO2

Molecular Weight:: 201.02

MDL Number:: MFCD03033065

MOL File:: 2973-80-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:42

Product description	Number	Pack Size	Price
2-Bromo-5-hydroxybenzaldehyde 95%	710814	1g	$150
2-Bromo-5-hydroxybenzaldehyde >97.0%(GC)	B3997	1g	$34
2-Bromo-5-hydroxybenzaldehyde >97.0%(GC)	B3997	5g	$129
2-Bromo-5-hydroxybenzaldehyde	B684690	5g	$225
2-Bromo-5-hydroxybenzaldehyde	159437	500mg	$496
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2-BROMO-5-HYDROXYBENZALDEHYDE Properties

Melting point	130-135 °C
Boiling point	286.7±20.0 °C(Predicted)
Density	1.737±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in chloroform, dichloromethane and ethyl acetate.
form	Solid
pka	8.67±0.18(Predicted)
color	White to Gray to Brown
InChI	InChI=1S/C7H5BrO2/c8-7-2-1-6(10)3-5(7)4-9/h1-4,10H
InChIKey	SCRQAWQJSSKCFN-UHFFFAOYSA-N
SMILES	C(=O)C1=CC(O)=CC=C1Br
CAS DataBase Reference	2973-80-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H400

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 3077

WGK Germany

Hazard Note

Irritant

HazardClass

PackingGroup

III

HS Code

2909500090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1

NFPA 704

	1
2		0

2-BROMO-5-HYDROXYBENZALDEHYDE price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	710814	2-Bromo-5-hydroxybenzaldehyde 95%	2973-80-0	1g	$150	2026-04-30	Buy
TCI Chemical	B3997	2-Bromo-5-hydroxybenzaldehyde >97.0%(GC)	2973-80-0	1g	$34	2026-04-30	Buy
TCI Chemical	B3997	2-Bromo-5-hydroxybenzaldehyde >97.0%(GC)	2973-80-0	5g	$129	2026-04-30	Buy
TRC	B684690	2-Bromo-5-hydroxybenzaldehyde	2973-80-0	5g	$225	2021-12-16	Buy
Usbiological	159437	2-Bromo-5-hydroxybenzaldehyde	2973-80-0	500mg	$496	2021-12-16	Buy

Product number	Packaging	Price	Buy
710814	1g	$150	Buy
B3997	1g	$34	Buy
B3997	5g	$129	Buy
B684690	5g	$225	Buy
159437	500mg	$496	Buy

2-BROMO-5-HYDROXYBENZALDEHYDE Chemical Properties,Uses,Production

Chemical Properties

Pale Grey Solid

Uses

2-Bromo-5-hydroxybenzadehyde is a reactant used in the preparation of many pharmaceutical agents: Bcl-XL, PDE4 inhibitors, inhibitors of prostate cancer cell growth and anti-inflamatory agents.

Uses

2-Bromo-5-hydroxybenzaldehyde is a useful reactant used in the synthesis of PDE4 inhibitors, BCL-XL and cancel cell growth inhibitors. Also an reactant used in the preparation of many pharmaceutical agents.

Synthesis

100-83-4

2973-80-0

General procedure for the synthesis of 2-bromo-5-hydroxybenzaldehyde from m-hydroxybenzaldehyde: 3-hydroxybenzaldehyde (120 g, 0.98 mol) was suspended in 2400 mL of dichloromethane (CH2Cl2) in a 5 L four-necked, round-bottomed flask fitted with an overhead stirrer, a temperature probe, a dosing funnel, and a condenser tube. The mixture was heated to 35-40 °C to completely dissolve the raw material. Bromine (52 mL, 1.0 mol, 1.02 eq.) was added slowly dropwise through the addition funnel, controlling the rate of dropwise acceleration to maintain the reaction temperature between 35-38°C. After dropwise addition, the reaction mixture was stirred at 35 °C overnight. Subsequently, the mixture was slowly cooled to -5-0 °C over a period of 2 h and stirring was continued for 1 h at this temperature. The precipitated solid was collected by filtration through a Brinell funnel and the filter cake was washed with 400 mL of cold 1:1 n-heptane/dichloromethane mixture. The resulting gray solid was dried under vacuum at room temperature (0.2 mmHg). The yield was 124.3 g in 63% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 8, p. 955 - 959
[2] Patent: US2004/19018, 2004, A1. Location in patent: Page/Page column Sheet 2
[3] Journal of the Iranian Chemical Society, 2011, vol. 8, # 2, p. 531 - 536
[4] Tetrahedron Letters, 2009, vol. 50, # 9, p. 1007 - 1009
[5] Synthetic Communications, 2007, vol. 37, # 4, p. 581 - 585

2-BROMO-5-HYDROXYBENZALDEHYDE synthesis

Synthesis of 2-BROMO-5-HYDROXYBENZALDEHYDE from 2-Bromo-5-methoxybenzaldehyde

2-BROMO-5-HYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

2,4-Dibromo-5-hydroxybenzaldehyde 4-BROMO-3-HYDROXYBENZALDEHYDE 3-Hydroxy-4-nitrobenzaldehyde 2-Bromo-5-methoxybenzaldehyde 2-Bromo-3-hydroxybenzaldehyde

Dichloromethane 3-Hydroxybenzaldehyde

1of2

Preparation Products

2-Bromo-5-methoxybenzaldehyde 4-Bromo-3-methylphenol 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile

2-BROMO-5-HYDROXYBENZALDEHYDE Suppliers

Global( 430)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5899	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091	info@rochipharma.com	China	246	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	773	58
Wuhan Biocar Pharmacy CO.,Ltd.	+86-86-13343427080 +8613343427080	wxxxxxxj@gmail.com	China	495	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1085	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Golden Pharma Co., Limited	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	58
Wuhan Biocar Pharmacy CO.,Ltd.	58
Hebei Xinsheng New Material Technology Co., LTD.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2-BROMO-5-HYDROXYBENZALDEHYDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-19	2-bromo-5-hydroxybenzaldehyde 2973-80-0	US $0.00-0.00 / kg	1kg	99%	1T	Shandong Hanjiang Chemical Co., Ltd
2025-12-25	2-BROMO-5-HYDROXYBENZALDEHYDE 2973-80-0	US $0.00-0.00 / kg	1kg	0.99	800kg	Wuhan Biocar Pharmacy CO.,Ltd.
2025-12-01	2-BROMO-5-HYDROXYBENZALDEHYDE 2973-80-0	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-bromo-5-hydroxybenzaldehyde
2973-80-0
US $0.00-0.00 / kg
99%
Shandong Hanjiang Chemical Co., Ltd

2-BROMO-5-HYDROXYBENZALDEHYDE
2973-80-0
US $0.00-0.00 / kg
0.99
Wuhan Biocar Pharmacy CO.,Ltd.

2-BROMO-5-HYDROXYBENZALDEHYDE
2973-80-0
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

2-BROMO-5-HYDROXYBENZALDEHYDE Spectrum

2-BROMO-5-HYDROXYBENZALDEHYDE(2973-80-0)¹HNMR 2-BROMO-5-HYDROXYBENZALDEHYDE(2973-80-0)FT-IR

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2-BroMo-5-hydroxybenzaldehyde, 98%+ Benzaldehyde, 2-bromo-5-hydroxy- 2-Bromo-5-hydroxybenzaldehyde 95% 4-BROMO-3-FORMYLPHENOL AKOS B020430 2-BROMO-5-HYDROXYBENZALDEHYDE ART-CHEM-BB B020430 2-bromo-5-hydroxybenzadehyde 2-BROMO-5-HYDROXYBENZALDEHYDE ISO 9001：2015 REACH Crisaborole Impurity 32 Crisaborole Related Compound 2 2-Bromo-5-hydroxybenzaldehyde > -BROMO-5-HYDROXYBENZALDEHYDE 2-Bromo-5-(Hydroxyl)Benzaldehyde Crisaborole-029 2973-80-0 2-Bromo-5hydroxybenzaldehyde 2973-80-0 2-Bromo-5-hydroxybenzaldehyde, CAS 2973-80-0 2973-80-0 2973-80-8 2873-80-0 C7H5O2Br API intermediates Aryl Halogenated Organohalides