Dabigatran Acyl-β-D-Glucuronide
- CAS No.
- 1015167-40-4
- Chemical Name:
- Dabigatran Acyl-β-D-Glucuronide
- Synonyms
- Dabigatran Impurity 110;Dabigatran Acyl Glucuronide;Dabigatran Acyl-β-D-Glucuronide;Dabigatran Acyl-β-D-Glucuronide;Dabigatran β-Acyl Glucuronide D4;Dabigatran Acyl-Beta-D-Glucuronide;Dabigatran Acyl-?-D-Glucuronide TFA Salt;Dabigatran Acyl-?-D-Glucuronide-D3 TFA Salt;Dabigatran Acyl--D- glucuronide trifluroacetic acid;Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt
- CBNumber:
- CB12558083
- Molecular Formula:
- C31H33N7O9
- Molecular Weight:
- 647.63522
- MDL Number:
- MFCD21363575
- MOL File:
- 1015167-40-4.mol
| Melting point | >155°C (dec.) |
|---|---|
| Boiling point | 968.1±75.0 °C(Predicted) |
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water |
| form | Solid |
| pka | 2.68±0.70(Predicted) |
| color | Off-White to Light Brown |
| Stability | Hygroscopic, Unstable in Solution |
| FDA UNII | U53A719N8O |
Dabigatran Acyl-β-D-Glucuronide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26655 | Dabigatran Acyl-β-D-Glucuronide | 1015167-40-4 | 1mg | $893 | 2023-06-20 | Buy |
| TRC | D100085 | DabigatranAcyl-β-D-GlucuronideTrifluoroaceticAcidSalt(80%) | 1015167-40-4 | 1mg | $485 | 2021-12-16 | Buy |
| TRC | D100085 | DabigatranAcyl-β-D-GlucuronideTrifluoroaceticAcidSalt(80%) | 1015167-40-4 | 10mg | $3875 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 79818 | Dabigatranacyl-β-D-glucuronide | 1015167-40-4 | 5mg | $2390 | 2021-12-16 | Buy |
| Chemtos | D-2143 | Dabigatran-acyl-glucuronide(isomermix) | 1015167-40-4 | 10mg | $2990 | 2021-12-16 | Buy |
Dabigatran Acyl-β-D-Glucuronide Chemical Properties,Uses,Production
Description
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.
Uses
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt is a major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).
Uses
A metabolite of Dabigatran.
Uses
The major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. ?NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).
Dabigatran Acyl-β-D-Glucuronide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 1000 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 3066 | 58 |
| Clearsynth Canada Inc. | +1.415.685.4395 | enquiry@clearsynth.com | Canada | 912 | 58 |