AZD5363
- CAS No.
- 1143532-39-1
- Chemical Name:
- AZD5363
- Synonyms
- Capivasertib;4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-;CS-561;AZD5636;AZD5363;AZD5356;AZD5363 USP/EP/BP;AZD-5363; AZD 5363;AZD5363(Capivasertib);CAPIVASERTIB (AZD5363)
- CBNumber:
- CB12650349
- Molecular Formula:
- C21H25ClN6O2
- Molecular Weight:
- 428.92
- MDL Number:
- MFCD22628785
- MOL File:
- 1143532-39-1.mol
| Melting point | 161-164°C |
|---|---|
| Density | 1.381 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.93±0.50(Predicted) |
| form | Solid |
| color | Off-White to Pale Beige |
| FDA UNII | WFR23M21IE |
| NCI Drug Dictionary | capivasertib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AZD5363 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 1143532-39-1 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 1143532-39-1 | 5mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 1143532-39-1 | 10mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 1143532-39-1 | 25mg | $412 | 2024-03-01 | Buy |
| Tocris | 6978 | AZD5363 ≥98%(HPLC) | 1143532-39-1 | 25 | $545 | 2021-12-16 | Buy |
AZD5363 Chemical Properties,Uses,Production
Uses
AZD5363 is used in inhibiting the proliferation of certain tumor cell lines.
Biological Activity
azd5363 is a novel, potent phosphoinositide 3-kinase (pi3k)/akt pathway inhibitor with ic50 value of ~200nm. [1]azd5363 is proved to inhibit castrate resistant prostate cancer (crpc) progression. clusterin (clu) and autophagy will be induced which may work as cytoprotective responses which can affect the downstream pi3k/akt signaling. [2] azd5363 inhibits the growth of a lot of human tumor cells in a dose dependent manner. the mode of action could be monotherapy as well as in combination with her2 inhibitors in breast cancer models. [3] it is suggested to induce cell apoptosis by measuring the expression of parp cleavage, the activity of caspase 3, et al. [1]most importantly, azd5363 can target the pi3k/akt-pathway in vivo significantly, thus reducing the serum psa-levels and tumor volume, finally, it could postpone the progression to crpc.[1]
target
Akt
storage
Store at -20°C
References
[1] thomas c, crafter c, davies b, zoubeidi a, gleave me. azd5363, a novel akt inhibitor, delays prostate cancer progression. the journal of urology. may 2011. 185(4s): e292-293.
[2] kumano m, zhang f, shiota m, crafter c, davies b, zoubeidi a, gleave m. clusterin knockdown enhances antitumor activity of a novel akt inhibitor, azd5363, through inhibition of autophagy in prostate cancer. the journal of urology. may 21 2012. e392.
[3] davies br, greenwood h, dudley p, et al. preclinical pharmacology of azd5363, an inhibitor of akt: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. mol. cancer ther. arp 2012. 11: 873.
AZD5363 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28302 | 58 |
