Tropodithietic acid [TDA]
- CAS No.
- 750590-18-2
- Chemical Name:
- Tropodithietic acid [TDA]
- Synonyms
- Tropodithietic acid;Tropodithietic acid [TDA];from Phaeobacter inhibens;3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid;8,9-Dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid, 3-oxo-
- CBNumber:
- CB12650819
- Molecular Formula:
- C8H4O3S2
- Molecular Weight:
- 212.24556
- MDL Number:
- MFCD24485342
- MOL File:
- 750590-18-2.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 2941900000 | |||||||||
NFPA 704 |
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Tropodithietic acid [TDA] price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0735 | Tropodithietic acid ≥98% (HPLC) | 750590-18-2 | 5mg | $861 | 2022-05-15 | Buy |
Cayman Chemical | 23244 | Tropodithietic Acid ≥98% | 750590-18-2 | 1mg | $171 | 2024-03-01 | Buy |
Usbiological | 207429 | Tropodithietic acid | 750590-18-2 | 1mg | $359 | 2021-12-16 | Buy |
TRC | T892703 | Tropodithietic acid | 750590-18-2 | 2.5mg | $475 | 2021-12-16 | Buy |
Adipogen Life Sciences | BVT-0152-M001 | Tropodithietic acid ≥98%(HPLC) | 750590-18-2 | 1mg | $90 | 2021-12-16 | Buy |
Tropodithietic acid [TDA] Chemical Properties,Uses,Production
Description
Tropodithietic acid (750590-18-2) displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3
Uses
Tropodithietic Acid (cas# 750590-18-2) is a compound useful in organic synthesis.
Definition
ChEBI: Tropodithietic acid is a monocarboxylic acid that is 8,9-dithiabicyclo[5.2.0]nona-1,3,6-triene substituted by a carboxy group at position 2 and an oxo group at position 3. It is a broad spectrum antibiotic produced by the marine bacterium Phaeobacter inhibens that also acts as a signalling molecule at lower concentrations. It has a role as a toxin, a signalling molecule, a marine metabolite, an antibacterial agent and a bacterial metabolite. It is an organic disulfide, a cyclic ketone, an organosulfur heterocyclic compound, an organic heterobicyclic compound and a monocarboxylic acid. It is a tautomer of a thiotropocin.
storage
+4°C
References
1) Wilson et al. (2016), Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink; Proc. Natl. Acad. Sci. USA, 113 1630 2) Wichmann et al. (2015), Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin; Mar. Drugs, 13 7113 3) Rasmussen et al. (2016), Vibro anguillarum is Genetically and Phenotypically Unaffected by Long-Term Continuous Exposure to the Antibacterial Compound Tropodithietic Acid; Appl. Environ. Microbiol., 82 4802
Tropodithietic acid [TDA] Preparation Products And Raw materials
Raw materials
Preparation Products
Tropodithietic acid [TDA] Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 029-61856359 19815193980 | 1018@dideu.com | China | 10011 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11442 | 58 |