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c-GpAp

c-GpAp structure

CAS No.: 849214-04-6

Chemical Name:: c-GpAp

Synonyms: cGAMP;c-GpAp;di-GAMP;di-cGAMP;3'3'-cGAMP;3'3'-cGAMP;Cyclic GMP-AMP;cGAMP free acid;cGAMP ammonium salt;cGAMP 3',3'-cGAMP

CBNumber:: CB12695700

Molecular Formula:: C20H24N10O13P2

Molecular Weight:: 674.41

MDL Number:: MFCD28411367

MOL File:: 849214-04-6.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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c-GpAp Properties

Boiling point	1159.9±75.0 °C(Predicted)
Density	2.61±0.1 g/cm3(Predicted)
storage temp.	-20°C
pka	0.96±0.70(Predicted)
form	powder
color	white to beige
Water Solubility	Water : 20 mg/mL (29.66 mM)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

c-GpAp price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1232	cGAMP sodium salt ≥98% (HPLC)	849214-04-6	.5UMO	$211	2023-06-20	Buy
TRC	G110500	c-GpAp	849214-04-6	10mg	$13390	2021-12-16	Buy
ChemScene	CS-3892	cGAMP 99.22%	849214-04-6	10mg	$2150	2021-12-16	Buy
ChemScene	CS-3892	cGAMP 99.22%	849214-04-6	25mg	$3750	2021-12-16	Buy
Biosynth Carbosynth	NC137624	3',3'-Cyclic guanosine monophosphate-adenosine monophosphate	849214-04-6	500ug	$300	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1232	.5UMO	$211	Buy
G110500	10mg	$13390	Buy
CS-3892	10mg	$2150	Buy
CS-3892	25mg	$3750	Buy
NC137624	500ug	$300	Buy

c-GpAp Chemical Properties,Uses,Production

Uses

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Uses

c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.

Definition

ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).

Biochem/physiol Actions

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

storage

+4°C

c-GpAp Preparation Products And Raw materials

Raw materials

Preparation Products

c-GpAp Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9980	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4664	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
NewCan Biotech Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58

c-GpAp di-GAMP di-cGAMP cGAMP 3'3'-cGAMP cGAMP (Cyclic GMP-AMP 3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate RFCBNSCSPXMEBK-XRIIRFCZSA-N c-(ApGp) / 3'3'-cGAMP Cyclic GMP-AMP cGAMP ammonium salt cGAMP free acid cGAMP 3',3'-cGAMP 2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one 2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one 3'3'-cGAMP 849214-04-6 C20H22N10O13P22Na Nucleotides, Bases & Related Reagents, Derivatives