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ledipasvir interMediate

ledipasvir interMediate structure

CAS No.: 1256387-87-7

Chemical Name:: ledipasvir interMediate

Synonyms: (1R,3S,4S);Ledipasvir Impurity 12;Ledipasvir Intermediate 1;Intermediate of Redipavir;Ledipasvir Intermediate 09;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid;(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl...;(1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-ethyl ester;2-[(1R,3S,4S)-2-Boc-2-azabicyclo[2.2.1]heptan-3-yl]-1H-benzimidazole-6-boronic Acid Pinacol Ester;(1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl)

CBNumber:: CB12710876

Molecular Formula:: C24H34BN3O4

Molecular Weight:: 439.36

MDL Number:: MFCD28386938

MOL File:: 1256387-87-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:22:21

Product description	Number	Pack Size	Price
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	GAC38787	5g	$900
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	GAC38787	2g	$900
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	GAC38787	1g	$900
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	GAC38787	0.5g	$900
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	GAC38787	0.25g	$900
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ledipasvir interMediate Properties

Boiling point	613.5±35.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	12.16±0.10(Predicted)
Appearance	Off-white to light yellow Solid
InChIKey	MYPUONINDNZBTH-GMBSWORKSA-N
SMILES	[C@]12([H])C[C@]([H])(CC1)[C@@H](C1NC3=CC(B4OC(C)(C)C(C)(C)O4)=CC=C3N=1)N2C(OC(C)(C)C)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

ledipasvir interMediate price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	GAC38787	(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	1256387-87-7	5g	$900	2026-06-04	Buy
Biosynth	GAC38787	(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	1256387-87-7	2g	$900	2026-06-04	Buy
Biosynth	GAC38787	(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	1256387-87-7	1g	$900	2026-06-04	Buy
Biosynth	GAC38787	(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	1256387-87-7	0.5g	$900	2026-06-04	Buy
Biosynth	GAC38787	(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1 -dimethylethyl ester	1256387-87-7	0.25g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
GAC38787	5g	$900	Buy
GAC38787	2g	$900	Buy
GAC38787	1g	$900	Buy
GAC38787	0.5g	$900	Buy
GAC38787	0.25g	$900	Buy

ledipasvir interMediate Chemical Properties,Uses,Production

Synthesis

2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)-

1256387-74-2

1,4-Benzenediboronic acid bis(pinacol) ester

99770-93-1

1256387-87-7

I. Preparation of Compound 613: tert-Butyl (1R,3S,4S)-3-(6-bromo-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate (264 mg, 0.673 mmol), bis(pinacol) 1,4-phenylene diboronate (5 eq, 3.36 g, 6.95 mmol), tetrakis(triphenylphosphine) A mixture of palladium (5%, 39 mg) and 2M aqueous potassium carbonate (3 eq, 1.01 mL) in 5 mL of 1,2-dimethoxyethane (DME) was heated to 90°C for 4 hours under argon protection. After completion of the reaction, the reaction mixture was cooled, diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, concentrated, and purified by fast column chromatography (silica gel, 20% to 60% ethyl acetate/hexane gradient elution) to afford (1R,3S,4S)-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1] Heptane-2-carboxylic acid tert-butyl ester (295 mg, 85% yield).LCMS-ESI (m/z): [M+H]+ Calculated value C30H38BN3O4: 515.45; Measured value: 516.1.

References

[1] Patent: WO2013/40492, 2013, A2. Location in patent: Page/Page column 91-92
[2] Patent: US2013/273005, 2013, A1. Location in patent: Paragraph 0350

ledipasvir interMediate Preparation Products And Raw materials

Raw materials

2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)- 1,4-Benzenediboronic acid bis(pinacol) ester Bis(pinacolato)diboron Tetrakis(triphenylphosphine)palladium Potassium carbonate

Water 1,2-Dimethoxyethane

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Preparation Products

ledipasvir interMediate Suppliers

Global( 142)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	505	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27033	58
AFINE CHEMICALS LIMITED	+86-571-85134551	info@afinechem.com	China	15083	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Standardpharm Co. Ltd.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from ledipasvir interMediate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	ledipasvir interMediate 1256387-87-7	$1.10	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2019-07-06	ledipasvir interMediate 1256387-87-7	$2.00	1KG	99%		Career Henan Chemical Co
2018-03-07	(1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl) 1256387-87-7	$1.00	1KG	99%	100t	Shanghai Yingrui Biopharma Co., Ltd.

ledipasvir interMediate
1256387-87-7
$1.10
99.0% Min
Dideu Industries Group Limited

ledipasvir interMediate
1256387-87-7
$2.00
99%
Career Henan Chemical Co

(1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl)
1256387-87-7
$1.00
99%
Shanghai Yingrui Biopharma Co., Ltd.

ledipasvir interMediate Spectrum

ledipasvir interMediate(1256387-87-7)¹HNMR

1256387-87-7(ledipasvir interMediate)Related Search:

ledipasvir interMediate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate (1S)-1-(diphenylphosphino)-2-[(1R)-1-(diphenylphosphino)ethyl]-Ferrocene (S)-1-[(R)-2-(DI-TERT.-BUTYLPHOSPHINO)FERROCENYL]ETHYLBIS(2-METHYLPHENYL)PHOSPHI (1R,2R)-(-)-1,2-Diaminocyclohexane

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Ledipasvir ledipasvir interMediate ledipasvir interMediate 2,7-DibroMo-9,9-difluoro-9H-fluorene

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)- (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone ledipasvir interMediate

(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

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Identification Name (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester tert-butyl (1R,3S,4S)-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate (1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl) (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benziMidazol-2-yl]-, 1,1-diMethylethyl ester, (1R,3S,4S)- (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester (1R,3S,4S)-2-tert-butyl-3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[D]iMidazol-2-yl)-2-azabicyclo[2.2.1]hept (1R,3S,4S)-2-tert-butyl-3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[D]iMidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid Ledipasvir Intermediate 09 Ledipasvir Intermediate 1 (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-inden-2-yl)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate Identification Name (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2- (2-((1R,3S,4S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[2.2.1]HEPTAN-3-YL)-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER 1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2. (1R,3S,4S) (1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-ethyl ester 3-{6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-benzoimidazol-2-yl}-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester Ledipasvir Impurity 12 tert-butyl (1S,2S,4R)-2-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-3-azabicyclo[2.2.1]heptane-3-carboxylate (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl... (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-)Q: What is (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-) Q: What is the CAS Number of (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-) Q: What is the storage condition of (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-) Intermediate of Redipavir (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylicacid1,1-dimethylethylChemicalbookester 2-[(1R,3S,4S)-2-Boc-2-azabicyclo[2.2.1]heptan-3-yl]-1H-benzimidazole-6-boronic Acid Pinacol Ester 1256387-87-7 C24H34BN3O4