ChemicalBook >> CAS DataBase List >>GSK 2330672
GSK 2330672
- CAS No.
- 1345982-69-5
- Chemical Name:
- GSK 2330672
- Synonyms
- linerixibat;CS-2639;Iinerixibat;GSK 2330672;Iinerixibat (GSK2330672);linerixibat (GSK2330672);GSK 2330672; GSK-2330672;3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid;Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-;3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
- CBNumber:
- CB12716247
- Molecular Formula:
- C28H38N2O7S
- Molecular Weight:
- 546.68
- MDL Number:
- MFCD28386358
- MOL File:
- 1345982-69-5.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:09
Boiling point | 730.8±60.0 °C(Predicted) |
---|---|
Density | 1.218±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml |
form | A crystalline solid |
pka | 3.27±0.10(Predicted) |
FDA UNII | 386012Z45S |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335-H401-H411 | |||||||||
Precautionary statements | P261-P264-P270-P271-P273-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P391-P403+P233-P405-P501 | |||||||||
NFPA 704 |
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GSK 2330672 price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23843 | GSK2330672 ≥98% | 1345982-69-5 | 1mg | $110 | 2024-03-01 | Buy |
Cayman Chemical | 23843 | GSK2330672 ≥98% | 1345982-69-5 | 5mg | $515 | 2024-03-01 | Buy |
Cayman Chemical | 23843 | GSK2330672 ≥98% | 1345982-69-5 | 10mg | $918 | 2024-03-01 | Buy |
AK Scientific | 4578DL | Linerixibat | 1345982-69-5 | 5mg | $671 | 2021-12-16 | Buy |
Crysdot | CD31003808 | GSK2330672 98+% | 1345982-69-5 | 5mg | $208 | 2021-12-16 | Buy |
GSK 2330672 Chemical Properties,Uses,Production
Description
GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.
GSK 2330672 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 63)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
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Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
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InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
1345982-69-5(GSK 2330672)Related Search:
GSK 2330672
GSK 2330672; GSK-2330672
3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-
CS-2639
Iinerixibat
Iinerixibat (GSK2330672)
linerixibat
type-2,PBC,lipid-lowering,solubility,nonabsorbable,GSK-2330672,Inhibitor,Primary,diabetes,GSK 2330672,Cholangitis,inhibit,Linerixibat,aqueous,Biliary,ASBT
linerixibat (GSK2330672)
3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid
1345982-69-5