TOMATINE
- CAS No.
- 17406-45-0
- Chemical Name:
- TOMATINE
- Synonyms
- TOMATIN;omatine;Tomatie;TOMATINE;NSC 9223;a-Tomatine;NSC 234440;LYOCPERSICIN;LYCOPERSICIN;LYCOPERISCIN
- CBNumber:
- CB1292394
- Molecular Formula:
- C50H83NO21
- Molecular Weight:
- 1034.19
- MDL Number:
- MFCD00016888
- MOL File:
- 17406-45-0.mol
- MSDS File:
- SDS
| Melting point | 300-305°C |
|---|---|
| alpha | D20 -18° (c = 0.55 in pyridine) |
| Boiling point | 806.69°C (rough estimate) |
| Density | 1.48±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5280 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
| form | Solid |
| pka | 12.77±0.70(Predicted) |
| color | White to Off-White |
| Merck | 14,9545 |
| LogP | 2.220 (est) |
| CAS DataBase Reference | 17406-45-0 |
| EWG's Food Scores | 1 |
| FDA UNII | 31U6547O08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 23/25-22 | |||||||||
| Safety Statements | 45-24/25-22 | |||||||||
| RIDADR | 1544 | |||||||||
| RTECS | XW1050000 | |||||||||
| HS Code | 29329990 | |||||||||
| Toxicity | LD orally in rats: 900-1000 mg/kg (Wilson) | |||||||||
| NFPA 704 |
|
TOMATINE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3636 | Tomatine from Tomato >80.0%(HPLC) | 17406-45-0 | 100mg | $222 | 2024-03-01 | Buy |
| Usbiological | 297817 | Tomatine | 17406-45-0 | 25mg | $355 | 2021-12-16 | Buy |
| TRC | T538510 | Tomatine(85%) | 17406-45-0 | 5mg | $150 | 2021-12-16 | Buy |
| Usbiological | 301067 | Tomatine | 17406-45-0 | 10mg | $490 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 72695 | Tomatine(85%) | 17406-45-0 | 50mg | $610 | 2021-12-16 | Buy |
TOMATINE Chemical Properties,Uses,Production
Health Benifits
Tomatine (sometimes called tomatin or lycopersicin) is a glycoalkaloid, found in the stems and leaves of tomato plants, and in the fruits at much lower concentrations. It has fungicidal, antimicrobial, and insecticidal properties. Chemically pure tomatine is a white crystalline solid at standard temperature and pressure. Tomatine, as well as the closely related aglycon (or aglycone) derivative tomatidine have been shown to have multiple health benefits.
Tomatine is a steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galactose. It has a role as an immunological adjuvant, a phytotoxin and an antifungal agent. It is a steroid alkaloid, a tetrasaccharide derivative, an alkaloid antibiotic and a glycoside. It derives from a tomatidine.
Tomatine Toxin Symptoms
The possible risks of tomatine for humans have not been formally studied, so no NOAEL can be deduced. The toxicity of tomatine has only been studied on laboratory animals. The symptoms of acute tomatine poisoning in animals are similar to the symptoms of poisoning by solanine, a potato glycoalkaloid. These symptoms include vomiting, diarrhea, abdominal pain, drowsiness, confusion, weakness, and depression. Generally, tomatine is regarded to cause less toxic effect to mammals than other alkaloids such as solanine. The amount of tomatine absorbed by the human body as well as the possible metabolism is unknown. There is no evidence that consumption of tomatoes causes acute toxic or genotoxic effects.
Description
This glycosidic alkaloid has been obtained from the dried leaves of Lycopersicum pimpinelli/olium (Syn. Solanum racemigerum) and also occurs in L. esculentum; L. hirsutum; L. peruvianum; L. peruvianum var. chutatum and L. putatum. The alkaloid forms colourless needles from MeOH and has a somewhat indefinite melting point about 270°C. It is laevorotatory with [α]20D - 30° (pyridine) and on hydrolysis with H2S04 yields tomatidine, I mole of galactose, 2 moles of glucose and 1 mole of xylose. The tetrasaccharide unit is known as lycotetraose. Partial hydrolysis with acid yields a series of products depending upon which, and how many, of the sugar residues are split off from the molecule. Those which have been isolated are: tomatidine lycotriose I (galactose-glucose-glucose); tomatidine lycotriose II (galactose-glucose-xylose); tomatidine lycobiose (galactose-glucose) and tomatidine-galactose.
Chemical Properties
Faintly beige powder
Uses
Tomatine is used as an antiproliferatice agent used in the suppression of breast adenocarcinoma cells.
Uses
Precipitating agent for steroids.
Definition
ChEBI: A steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galac ose.
target
NF-kB | PI3K | Akt | ERK | MMP(e.g.TIMP) | AP-1 | ROS | Calcium Channel
Purification Methods
Tomatine is recrystallised from MeOH, EtOH, aqueous EtOH or dioxane/NH3. It is almost insoluble in pet ether, Et2O or H2O. [Reichstein Angew Chem 74 887 1962, Beilstein 27 III/IV 1954.]
References
Fontaine et al., Arch. Biochem., 18,467 (1948)
Kuhn, Low., Ber., 81, 552 (1948)
Kuhn, Low, Gauhe., ibid, 83,448 (1950)
Fontaine et al., Arch. Biochem., 27,461 (1950)
Fontaine et al., J. Amer. Chern. Soc., 73, 878 (1951)
Kuhn, Low, Trischmann., Angew. Chern., 68, 212 (1956)
Kuhn et al., Ber., 90, 203 (1957)
TOMATINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Related articles
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- Nov 23，2023
- Tomatine – a glycoalkaloid in tomato plants
- Tomatine is a glycoalkaloid, found in the stems and leaves of tomato plants, and in the fruits at much lower concentrations. I....
- Dec 23，2019
View Lastest Price from TOMATINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-28 | TOMATINE
17406-45-0
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-08-11 | TOMATINE
17406-45-0
|
US $0.00-0.00 / KG | 1KG | 99% | 10000kg/monnth | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-04-05 | TOMATINE
17406-45-0
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |