EPZ020411
- CAS No.
- 1700663-41-7
- Chemical Name:
- EPZ020411
- Synonyms
- CS-2262;EPZ020411;EPZ020411 2HCl;EPZ020411 HCl;EPZ 020411;EPZ-020411;N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
- CBNumber:
- CB13048651
- Molecular Formula:
- C25H38N4O3
- Molecular Weight:
- 442.59
- MDL Number:
- MFCD28963945
- MOL File:
- 1700663-41-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
EPZ020411 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19160 | EPZ020411 ≥98% | 1700663-41-7 | 1mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 19160 | EPZ020411 ≥98% | 1700663-41-7 | 5mg | $206 | 2024-03-01 | Buy |
| Cayman Chemical | 19160 | EPZ020411 ≥98% | 1700663-41-7 | 10mg | $360 | 2024-03-01 | Buy |
| Cayman Chemical | 19160 | EPZ020411 ≥98% | 1700663-41-7 | 25mg | $788 | 2024-03-01 | Buy |
| ApexBio Technology | B6088 | EPZ020411 | 1700663-41-7 | 50mg | $2048 | 2021-12-16 | Buy |
EPZ020411 Chemical Properties,Uses,Production
Biological Activity
epz020411 is an inhibitor of prmt6.prmt6, a member of the protein arginine methyltransferasefamily, comprises 45 enzymes. the post-translational modifications of prmt6 are important regulators of rna processing, transcriptional regulation, and signal transduction.
in vitro
in biochemical assays, epz020411 was found to be over 100-fold selective for prmt6/8/1 compared to other histone methyltransferases, such as prmt3, prmt4, prmt5 and prmt7. in addition, epz020411 treatment led to a dose-dependent decrease in h3r2 methylation, while treatment with its prmt6-inactive analog did not generate an ic50 at concentrations up to 20 μm [1].
in vivo
animal study found that male sd rats i.v. administered a single dose of epz020411 at 1 mg/kg showed a moderate clearance of 19.7 ml/min/kg, with a volume of distribution at steady state of 11.1 l/kg, and a mean terminal half-life of 8.54 h. following 5 mg/kg s.c. dosing, a good bioavailability of 65.6 was observed, resulting in epz020411 unbound concentration remaining over the prmt6 ic50 for more than 12 h [1].
IC 50
10 nm
References
[1] mitchell lh, et al. aryl pyrazoles as potent inhibitors of arginine methyltransferases: identification of the first prmt6 toolcompound. acs med chem lett. 2015 apr 6;6(6):655-659.
EPZ020411 Preparation Products And Raw materials
Raw materials
Preparation Products
EPZ020411 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16805 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Sphchem Co., Ltd. | 21-21-56491756 13512199871 | sales@panhongchem.com | China | 4001 | 55 |