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Chemical Name:
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methyl-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide;Frellana;Fluranaler;Florana;AH252723;Flurana*;Fluralaner;Fluralaner-012;A1443; AH252723;Fluralaner (A1443
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Mol file
MSDS File:
Last updated:2023-09-20 16:43:00

- Properties

Density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:150.0(Max Conc. mg/mL);269.65(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);44.94(Max Conc. mM)
pka 12.50±0.46(Predicted)
form A crystalline solid
SMILES C(NCC(=O)NCC(F)(F)F)(=O)C1=CC=C(C2CC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)ON=2)C=C1C


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H360-H410
Precautionary statements  P201-P202-P273-P281-P308+P313-P391-P405-P501

- price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22061 Fluralaner ≥98% 864731-61-3 50 mg $174 2023-06-20 Buy
Cayman Chemical 22061 Fluralaner ≥98% 864731-61-3 100 mg $328 2023-06-20 Buy
Cayman Chemical 22061 Fluralaner ≥98% 864731-61-3 1mg $39 2022-04-27 Buy
Cayman Chemical 22061 Fluralaner ≥98% 864731-61-3 5mg $142 2022-04-27 Buy
Cayman Chemical 22061 Fluralaner ≥98% 864731-61-3 10mg $39 2023-06-20 Buy
Product number Packaging Price Buy
22061 50 mg $174 Buy
22061 100 mg $328 Buy
22061 1mg $39 Buy
22061 5mg $142 Buy
22061 10mg $39 Buy

- Chemical Properties,Uses,Production


Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.


Fluralaner(864731-61-3) is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.


Fluralaner is an insecticide and acaricide used to treat Sarcoptes scabiei var. canis infestation in dogs. Flea treatment. A possible anti-malarial found to kill disease-spreading mosquitoes when they bite treated people.


Following oral administration, fluralaner is readily absorbed reaching maximum plasma concentrations within 1 day. Food enhances the absorption. Fluralaner is systemically distributed and reaches the highest concentrations in fat, followed by liver, kidney and muscle. The prolonged persistence and slow elimination from plasma (t1/2 = 12 days) and the lack of extensive metabolism provide effective concentrations of fluralaner for the duration of the inter-dosing interval. Individual variation in Cmax and t1/2 was observed. The major route of elimination is the excretion of unchanged fluralaner in faeces (~90% of the dose). Renal clearance is the minor route of elimination.

Side effects

Most pets have very few side effects from fluralaner, provided it is given according to label recommendations and at the prescribed interval (or for off-label use, according to your veterinarian's directions). Side effects may include vomiting, diarrhea, decreased appetite, or flaky skin.


No adverse reactions were observed following oral administration to puppies aged 8–9 weeks and weighing 2.0–3.6 kg treated with overdoses of up to 5 times the maximum recommended dose (56 mg, 168 mg and 280 mg fluralaner/kg bodyweight) on three occasions at shorter intervals than recommended (8-week intervals).
There were no findings on reproductive performance and no findings of concern on offspring viability when fluralaner was administered orally to Beagle dogs at overdoses of up to 3 times the maximum recommended dose (up to 168 mg/kg bodyweight of fluralaner).
The veterinary medicinal product was well tolerated in Collies with a deficient multidrug-resistanceprotein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose (168 mg/kg bodyweight). No treatment-related clinical signs were observed.

Drug interactions

Fluralaner is highly bound to plasma proteins and might compete with other highly bound drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and the cumarin derivative warfarin. Incubation of fluralaner in the presence of carprofen or warfarin in dog plasma at maximum expected plasma concentrations did not reduce the protein binding of fluralaner, carprofen or warfarin.
During clinical field testing, no interactions between Bravecto chewable tablets for dogs and routinely used veterinary medicinal products were observed.

Mode of action

Fluralaner is an inhibitor of the arthropod nervous system. It inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls). Potency of fluralaner is comparable to fipronil (a related GABA-antagonist insecticide and acaricide).

- Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 146)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420 China 896 58
Masteam Bio-tech Co., Ltd.
+86-15200345168 CHINA 153 58
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850 +86-13986145403 China 5985 58
Hpets Biotech Company (Chongqing) Co.,ltd
+86-13340353813 +86-13272734230 China 26 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040 China 6076 58
Wuhan Mayue Longteng Technology Development Co., Ltd.
+undefined15171477138 China 278 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 China 977 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9365 55
Fluoropharm Co., Ltd.
+8613336034509 China 1290 60
+undefined-21-51877795 China 32237 60

Related articles

  • The effects of fluralaner on dogs
  • Fluralaner is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after ....
  • Jan 6,2022

Related Qustion

  • Q:What is fluralaner?
  • A:cat_scratchingFluralaner (brand name Bravecto?) is used to treat and control flea and tick infestations in dogs and cats. Afte....
  • Oct 14,2019

View Lastest Price from - manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fluralaner pictures 2023-11-27 Fluralaner
US $40000.00 / kg 1kg 99% min 20 tons Wuhan Senwayer Century Chemical Co.,Ltd
Fluralaner pictures 2023-11-01 Fluralaner
US $0.00-0.00 / g 1g 99.0% min 100kgs Hangzhou ICH Biofarm Co., Ltd
Fluralaner pictures 2023-08-21 Fluralaner
US $0.00 / KG 1KG 98% HPLC 5 ton shandong perfect biotechnology
  • Fluralaner pictures
  • Fluralaner
  • US $40000.00 / kg
  • 99% min
  • Wuhan Senwayer Century Chemical Co.,Ltd
  • Fluralaner pictures
  • Fluralaner
  • US $0.00-0.00 / g
  • 99.0% min
  • Hangzhou ICH Biofarm Co., Ltd
  • Fluralaner pictures
  • Fluralaner
  • US $0.00 / KG
  • 98% HPLC
  • shandong perfect biotechnology

- Spectrum

Fluralaner 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide A1443; AH252723 AH252723 Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]- Fluralaner-012 Fluralaner (A1443 Fluralaner D2Q: What is Fluralaner D2 Q: What is the CAS Number of Fluralaner D2 Fluralaner D3Q: What is Fluralaner D3 Q: What is the CAS Number of Fluralaner D3 Fluralaner D5Q: What is Fluralaner D5 Q: What is the CAS Number of Fluralaner D5 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methyl-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide Frellana Fluranaler Florana 13C4,2H3]-Fluralaner Fluralaner 99% min Flurana* Fluralaner Impurity 12 864731-61-3 1 API 864731-61-3