Methyltetrazine-amido-PEG7-azide
- CAS No.
- 2112731-46-9
- Chemical Name:
- Methyltetrazine-amido-PEG7-azide
- Synonyms
- Methyltetrazine-amido-PEG7-azide
- CBNumber:
- CB13373647
- Molecular Formula:
- C27H42N8O8
- Molecular Weight:
- 606.68
- MDL Number:
- MFCD30723245
- MOL File:
- 2112731-46-9.mol
| Product description | Number | Pack Size | Price |
| Methyltetrazine-amido-PEG7-azide 98% | BP-23552 | 50mg | $380 |
Methyltetrazine-amido-PEG7-azide Chemical Properties,Uses,Production
Description
Methyltetrazine-amido-PEG7-azide is a bifunctional PEG crosslinker. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene) under miled condition, Azide(N3) group can enable copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.
Uses
Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-amido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Methyltetrazine-amido-PEG7-azide Preparation Products And Raw materials
Raw materials
Preparation Products
Methyltetrazine-amido-PEG7-azide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1994 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Shanghai Easy CDMO Co.,Ltd | 021-61734564 13854185395; | info@easycdmo.com | China | 10024 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 31870 | 58 |
