ChemicalBook >> CAS DataBase List >>N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

CAS No.
70375-43-8
Chemical Name:
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
Synonyms
SCH-202676;SCH202676 HBr;SCH-202676 HBr;SCH 202676 HBr;AURORA KA-7903;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
CBNumber:
CB1420216
Molecular Formula:
C15H13N3S
Molecular Weight:
267.35
MDL Number:
MFCD06671539
MOL File:
70375-43-8.mol
Last updated:2023-05-18 11:31:11

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Properties

Melting point 240.0-240.8 °C(lit.)
storage temp. Desiccate at +4°C
solubility DMSO: 40 mg/mL
form Yellow solid.
color Beige
Stability Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1400 SCH202676hydrobromide ≥99%(HPLC) 70375-43-8 10 $181 2021-12-16 Buy
Tocris 1400 SCH202676hydrobromide ≥99%(HPLC) 70375-43-8 50 $749 2021-12-16 Buy
TRC S200038 SCH-202676 70375-43-8 10mg $95 2021-12-16 Buy
Usbiological 256627 SCH 202676 hydrobromide 70375-43-8 10mg $438 2021-12-16 Buy
American Custom Chemicals Corporation INB0000135 SCH-202676 95.00% 70375-43-8 10MG $250.95 2021-12-16 Buy
Product number Packaging Price Buy
1400 10 $181 Buy
1400 50 $749 Buy
S200038 10mg $95 Buy
256627 10mg $438 Buy
INB0000135 10MG $250.95 Buy

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Uses,Production

Description

SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3

Uses

SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.

Biological Activity

Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).

References

1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30 2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422 3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 38)Suppliers
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TargetMol Chemicals Inc.
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Aladdin Scientific
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
United States Biological -- sales@advtechind.com United States 6106 58
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE SCH-202676 SCH 202676 HYDROBROMIDE AURORA KA-7903 N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)- SCH 202676 HBr SCH202676 HBr SCH-202676 HBr SCH 202676 HBr,SCH202676 HBr 70375-43-8 C15H16BrN3S C15H13N3SHBr Cell Signaling and Neuroscience Cell Biology BioChemical Reagents G Proteins and Cyclic Nucleotides G Protein Function G-Protein