N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- CAS No.
- 70375-43-8
- Chemical Name:
- N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- Synonyms
- SCH-202676;SCH202676 HBr;SCH-202676 HBr;SCH 202676 HBr;AURORA KA-7903;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- CBNumber:
- CB1420216
- Molecular Formula:
- C15H13N3S
- Molecular Weight:
- 267.35
- MDL Number:
- MFCD06671539
- MOL File:
- 70375-43-8.mol
| Melting point | 240.0-240.8 °C(lit.) |
|---|---|
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 40 mg/mL |
| form | Yellow solid. |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1400 | SCH202676hydrobromide ≥99%(HPLC) | 70375-43-8 | 10 | $181 | 2021-12-16 | Buy |
| Tocris | 1400 | SCH202676hydrobromide ≥99%(HPLC) | 70375-43-8 | 50 | $749 | 2021-12-16 | Buy |
| TRC | S200038 | SCH-202676 | 70375-43-8 | 10mg | $95 | 2021-12-16 | Buy |
| Usbiological | 256627 | SCH 202676 hydrobromide | 70375-43-8 | 10mg | $438 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000135 | SCH-202676 95.00% | 70375-43-8 | 10MG | $250.95 | 2021-12-16 | Buy |
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Uses,Production
Description
SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3
Uses
SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).
References
1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30 2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422 3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 18779 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |