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Samidorphan

Samidorphan structure

CAS No.: 421552-35-4

Chemical Name:: Samidorphan

Synonyms: Samidorphan;Samidorphan N-1;Samidorphan Impurity;Samidorphan Impurity 30;3-Carboxamidonaltrexone;Morphinan-3-carboxamide, 17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxo-, (5α)-

CBNumber:: CB14694309

Molecular Formula:: C21H24N2O4

Molecular Weight:: 368.43

MDL Number:

MOL File:: 421552-35-4.mol

Last updated:2025-04-17 18:22:24

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Samidorphan Properties

Boiling point	547.2±50.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	13.22±0.20(Predicted)
InChIKey	QAICPHMNUHNDMC-PIBUYISVNA-N
SMILES	O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])N(CC1CC1)CC[C@@]23C4=5)C(=O)N \|&1:1,6,15,24,r\|

Samidorphan Chemical Properties,Uses,Production

Uses

3-Carboxamidonaltrexone (example 32) is a opioid receptor binding compound with Ki values of 1.9 nM, 110 nM, and 22 nM for μ-opioid receptor, δ-opioid receptor, and K-opioid receptor, respectively[1].

IC 50

μ Opioid Receptor/MOR: 1.9 nM (Ki); κ Opioid Receptor/KOR: 22 nM (Ki); δ Opioid Receptor/DOR: 110 nM (Ki)

References

[1] Mark P. Wentland. 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents. WO2002036573A2.

Samidorphan Preparation Products And Raw materials

Raw materials

Preparation Products

Samidorphan Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd	+86-13909357309; +8613909357309	eky7309@126.com	China	3	58
Guangzhou Tosun Pharmaceutical Ltd	+86-020-61855200-902 +8618124244216	info@upharm.cn	China	897	58
TOSUN PHARM	020-61855200 13326451905	260366801@qq.com	China	7924	58
Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd	013909357309 13909353777	419314657@qq.com	China	2	58
Artis Biotech Co. Ltd.	028-67271278 18628360895	sales@artisbio.com	China	1975	58
Suzhou Meishi Biotechnology Co., Ltd.	1173954148q	meishipharma@126.com	China	20033	58
Shaanxi Xihua Chemical Industry Co., Ltd	029-029-81123119 17391733320	1021@dideu.com	China	10001	58

Supplier	Advantage
Moxin Chemicals	58
Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd	58
Guangzhou Tosun Pharmaceutical Ltd	58
TOSUN PHARM	58
Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd	58
Artis Biotech Co. Ltd.	58
Suzhou Meishi Biotechnology Co., Ltd.	58
Shaanxi Xihua Chemical Industry Co., Ltd	58

Samidorphan：Synthesis and Introduction
Samidorphan is synthesised using naltrexone as raw material by chemical reaction. Samidorphan and Olanzapine is a co-formulate....
Jan 15，2024

View Lastest Price from Samidorphan manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-31	Samidorphan Impurity 421552-35-4	US $0.00-0.00 / mg	10mg	95%+	1000000	Moxin Chemicals
	2022-10-14	Samidorphan 421552-35-4	US $0.00 / kg	1kg	≥98.00%	200000kg	Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd

Samidorphan Impurity
421552-35-4
US $0.00-0.00 / mg
95%+
Moxin Chemicals

Samidorphan
421552-35-4
US $0.00 / kg
≥98.00%
Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd

Morphinan-3-carboxamide, 17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxo-, (5α)- Samidorphan Samidorphan N-1 3-Carboxamidonaltrexone Samidorphan Impurity Samidorphan Impurity 30 421552-35-4