Denbufylline
- CAS No.
- 57076-71-8
- Chemical Name:
- Denbufylline
- Synonyms
- brl30892;DENBUFYLLINE;1,3-DI-N-BUTYL-7-(2'-OXOPROPYL)XANTHINE;7-Acetonyl-1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-2,6-dione;1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione;1H-Purine-2,6-dione, 1,3-dibutyl-3,7-dihydro-7-(2-oxopropyl)-
- CBNumber:
- CB1704523
- Molecular Formula:
- C16H24N4O3
- Molecular Weight:
- 320.39
- MDL Number:
- MFCD00867152
- MOL File:
- 57076-71-8.mol
| Melting point | 98-100°C |
|---|---|
| Boiling point | 514.8±56.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | -0.17±0.70(Predicted) |
| color | Off-White to Pale Beige |
| CAS DataBase Reference | 57076-71-8 |
| FDA UNII | 04B949KO6F |
Denbufylline price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D231400 | Denbufylline | 57076-71-8 | 5mg | $80 | 2021-12-16 | Buy |
| Usbiological | D2743 | Denbufylline | 57076-71-8 | 10mg | $403 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21036 | Denbufylline | 57076-71-8 | 25mg | $425 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21036 | Denbufylline | 57076-71-8 | 50mg | $830 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21036 | Denbufylline | 57076-71-8 | 100mg | $1280 | 2021-12-16 | Buy |
Denbufylline Chemical Properties,Uses,Production
Description
Denbufylline, a xanthine derivative and PDE4 inhibitor, has effects such as vasodilatation of cerebral vessels (Willette et al., 1997) and potent activation of the hypothalamic–pituitary–adrenal axis. PDE4 is one of the cyclic adenosine monophosphate (cAMP)–specic phosphodiesterases whose tissue distribution is important in pathologies related to the central nervous and immune systems. In experimental animals, denbufylline increases adrenocorticotropic hormone (ACTH), circulating corticosterone, luteinizing hormone, corticotrophin-releasing hormone, and cAMP content of the hypothalamic tissue, but is without effect on arginine vasopressin (Kumari et al., 1997). Treves and Korczyn (1999) studied patients with AD, mixed dementia, and VaD treated with denbufylline. No signicant differences were found in comparison with placebo for the treatment of AD or VaD, although patients who received denbufylline tended to improve their cognitive scores.
Chemical Properties
White Solid
Uses
A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle apaillary muscle independently of its PDE inhibitory activity.
Uses
Bronchial spasmolysis agent
Definition
ChEBI: 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione is an oxopurine.
Denbufylline Preparation Products And Raw materials
Raw materials
Preparation Products
Denbufylline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Foshan Treasure Biotechnology Co., Ltd | 0757-85921206 18520245316 | 2329783215@qq.com | China | 12664 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Carbosynth | -- | sales@carbosynth.com | United Kingdom | 6018 | 58 |
Related articles
- Mechanism of action of Denbufylline
- Denbufylline, a xanthine derivative and PDE4 inhibitor, haseffects such as vasodilatation of cerebral vessels and potent activ....
- May 6，2022