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Benzothiazole

Benzothiazole
Benzothiazole structure
CAS No.
95-16-9
Chemical Name:
Benzothiazole
Synonyms
o-2857;NSC 8040;vangardbt;FEMA 3256;Vangard BT;usafek-4812;USAF ek-4812;Benzthiazole;Benzothiazol;benbinshanzuo
CBNumber:
CB1720657
Molecular Formula:
C7H5NS
Formula Weight:
135.19
MOL File:
95-16-9.mol

Benzothiazole Properties

Melting point:
2 °C (lit.)
Boiling point:
231 °C (lit.)
Density 
1.238 g/mL at 25 °C (lit.)
vapor density 
4.66 (vs air)
vapor pressure 
34 mm Hg ( 131 °C)
refractive index 
n20/D 1.642(lit.)
FEMA 
3256 | BENZOTHIAZOLE
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
3g/l
form 
Liquid
pka
0.85±0.10(Predicted)
color 
Clear yellow-brown to brown
Odor
odor of quinoline, sltly water-sol
explosive limit
0.9-8.2%(V)
Water Solubility 
slightly soluble
JECFA Number
1040
Merck 
14,1107
BRN 
109468
Stability:
Stable - regarded as highly persistent in the environment. Incompatible with strong oxidizing agents. Combustion products: nitrogen oxides, carbon monoxide, carbon dioxide, sulphur oxides.
InChIKey
IOJUPLGTWVMSFF-UHFFFAOYSA-N
CAS DataBase Reference
95-16-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
BENZOTHIAZOLE
EWG's Food Scores
1
FDA UNII
G5BW2593EP
NIST Chemistry Reference
Benzothiazole(95-16-9)
EPA Substance Registry System
Benzothiazole (95-16-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H302-H311-H320-H402-H301-H301+H311-H319-H332
Precautionary statements  P280-P301+P310-P305+P351+P338-P312-P301+P310+P330-P302+P352+P312-P261-P301+P310a-P501a-P264-P270-P273-P301+P312+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P405-P501
Hazard Codes  Xn,T,Xi
Risk Statements  22-20/21/22-36-25-24-20
Safety Statements  23-26-36-36/37-45
RIDADR  2810
WGK Germany  2
RTECS  DL0875000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29342080
Toxicity LD50 i.v. in mice: 95±3 mg/kg (Domino)
NFPA 704
1
2 0

Benzothiazole price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 101338 Benzothiazole 96% 95-16-9 5g $27.2 2021-03-22 Buy
Sigma-Aldrich 101338 Benzothiazole 96% 95-16-9 100g $40.3 2021-03-22 Buy
TCI Chemical B0092 Benzothiazole >96.0%(GC) 95-16-9 25mL $16 2021-03-22 Buy
TCI Chemical B0092 Benzothiazole >96.0%(GC) 95-16-9 100mL $34 2021-03-22 Buy
Alfa Aesar A10380 Benzothiazole, 97% 95-16-9 50g $20 2021-03-22 Buy

Benzothiazole Chemical Properties,Uses,Production

Description

Benzothiazole and its derivative are recognized as the most important heterocyclic compounds. This series of compounds is of particular interests. It has various kinds of pharmacological properties and has been included in many kinds of natural products and pharmaceutical agents. The broad spectrum of pharmacological activity in individual benzothiazole derivative enables it to serve as unique and valuable scaffolds for experimental drug design. It is already known that benzothiazole and its derivative has various biological applications including anticancer, antimicrobial, anticonvulsant, antiviral, antidiabetic, antipsychotic, antiinflammatory, analgesic, fungicidal and diuretic. Its derivatives also have many applications in polymer chemistry, dyes, drugs, and silver photography as well as rubber industry.

Chemical Properties

yellow liquid with an unpleasant odour

Chemical Properties

Benzothiazole has a delicate, persistent, rose-like odor similar to that of quinoline.

Occurrence

Reported found in apricot, cooked asparagus, mozzarella cheese, skim milk powder, roasted beef, beer, malt whiskey, coconut meat, fresh mango, cooked broccoli and kelp.

Uses

In organic synthesis.

Uses

Various benzothiazole-benzamides synthesized were evaluated for their analgesic and antidepressant activities.

Definition

ChEBI: An organic heterobicyclic compound that is a fusion product between benzene and thiazole. The parent of the class of benzothiazoles.

Preparation

By refluxing a mixture of zinc o-aminophenylsulfide and formic acid, followed by steam distillation of the alkalized reaction mixture; by heating formanilid or dimethylaniline with sulfur; by oxidation of 2-mercaptobenzothiazole or of the corresponding disulfide.

Aroma threshold values

Detection: 80 to 450 ppb

Taste threshold values

Taste characteristics at 3 ppm: meaty, vegetative, brown, cooked, beefy and coffee-like.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 6559, 1955 DOI: 10.1021/ja01629a041

Hazard

Highly toxic by ingestion.

Safety Profile

Poison by ingestion,intraperitoneal, intravenous, and possibly other routes.When heated to decomposition it emits very toxic fumesof SOx, CN??, and NOx.

References

Gupta, Akhilesh, and S. Rawat. "Synthesis and cyclization of benzothiazole." J. of Current Pharmaceutical Research 3.1 (2010): 13-25.
Keri, Rangappa S., et al. "A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry." European journal of medicinal chemistry 89 (2015): 207-251.
Khokra, Sukhbir L., et al. "Common methods to synthesize benzothiazole derivatives and their medicinal significance: a review." International Journal of Pharmaceutical Sciences and Research 2.6 (2011): 1356.

Benzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products


Benzothiazole Suppliers

Global( 313)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1714 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Chongqing Chemdad Co., Ltd
+86-13650506873
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View Lastest Price from Benzothiazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-06 Benzothiazole
95-16-9
US $0.00 / Kg/Drum 1KG 99% 2000mt/year Jinan Finer Chemical Co., Ltd
2021-12-01 Benzothiazole
95-16-9
US $2.60 / KG 1KG 99% 5000kg Hebei Crovell Biotech Co Ltd
2021-11-08 Benzothiazole
95-16-9
US $1.00 / g 1KG 99% 28Tons Wuhan wingroup Pharmaceutical Co., Ltd

Benzothiazole Spectrum


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