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DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE structure

CAS No.: 881-86-7

Chemical Name:: DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

Synonyms: Acifluorfen Impurity 7;dimethyl isocinchomeronate;Dimethyl-2,5-pyridinecarboxylate;Dimethy1-2.5-pyridineaarbanylate;2,5-Bis(methoxycarbonyl)pyridine;DIMETHYL 2,5-PYRIDINEDICARBOXYLATE;DIMETHYL PYRIDINE-2,5-DICARBOXYLATE;METHYL 6-METHOXYCARBONYL NICOTINATE;2,5-pyridine-dimethyl dicarboxylate;Dimethyl 2,5-pyridine dicarboxylate 97%

CBNumber:: CB1767704

Molecular Formula:: C9H9NO4

Molecular Weight:: 195.17

MDL Number:: MFCD00034767

MOL File:: 881-86-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:44

Product description	Number	Pack Size	Price
Dimethyl 2,5-pyridine dicarboxylate 97%	540234	25g	$106
Dimethyl 2,5-pyridine dicarboxylate	D479050	25g	$95
Dimethyl pyridine-2,5-dicarboxylate	FD153579	5G	$40
Dimethyl pyridine-2,5-dicarboxylate 97%	083391	25g	$55
Dimethyl pyridine-2,5-dicarboxylate	FD153579	10g	$60
More product size

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DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Properties

Melting point	213-217 °C(lit.)
Boiling point	302.9±22.0 °C(Predicted)
Density	1.231±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Dichloromethane, Ethyl Acetate
pka	-0.35±0.10(Predicted)
Appearance	White to off-white Solid
Water Solubility	Soluble in Dichloromethane and Ethyl Acetate. Insoluble in water.
BRN	172251
InChI	InChI=1S/C9H9NO4/c1-13-8(11)6-3-4-7(10-5-6)9(12)14-2/h3-5H,1-2H3
InChIKey	TUGSJNQAIMFEDY-UHFFFAOYSA-N
SMILES	C1(C(OC)=O)=NC=C(C(OC)=O)C=C1
CAS DataBase Reference	881-86-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2933399990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540234	Dimethyl 2,5-pyridine dicarboxylate 97%	881-86-7	25g	$106	2026-04-30	Buy
TRC	D479050	Dimethyl 2,5-pyridine dicarboxylate	881-86-7	25g	$95	2021-12-16	Buy
Biosynth Carbosynth	FD153579	Dimethyl pyridine-2,5-dicarboxylate	881-86-7	5G	$40	2021-12-16	Buy
Matrix Scientific	083391	Dimethyl pyridine-2,5-dicarboxylate 97%	881-86-7	25g	$55	2021-12-16	Buy
Biosynth Carbosynth	FD153579	Dimethyl pyridine-2,5-dicarboxylate	881-86-7	10g	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
540234	25g	$106	Buy
D479050	25g	$95	Buy
FD153579	5G	$40	Buy
083391	25g	$55	Buy
FD153579	10g	$60	Buy

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Chemical Properties,Uses,Production

Uses

It is the intermediate in the synthesis of potent antitumor agents.

Uses

Intermediate for the synthesis of potent antitumor agents.

General Description

Dimethyl 2,5-pyridine dicarboxylate can be prepared from 2,5-pyridinedicarboxylic acid.

Synthesis

67-56-1

100-26-5

881-86-7

Oxalyl chloride (60.96 g, 480 mmol) was slowly added dropwise over 20 min to a suspension of 2,5-pyridinedicarboxylic acid (20 g, 120 mmol) in dichloromethane (396 mL) and N,N-dimethylformamide (DMF, 6.6 mL). The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated under reduced pressure by rotary evaporator and the residue was azeotroped with toluene to remove residual water. The residue was dissolved in methanol (276 mL) pre-cooled to 0 °C and stirred for 15 min. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate solution, deionized water and saturated brine. Some of the product was collected as a white precipitate. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2,5-pyridinedicarboxylate as a white solid (Yield: 22.93 g, 98% yield). It was analyzed by liquid chromatography-mass spectrometry (LCMS, Method B) with a retention time (R t) of 2.48 min and a molecular ion peak [M + H] + = 196.

References

[1] Patent: WO2009/85983, 2009, A1. Location in patent: Page/Page column 65
[2] Molecules, 2014, vol. 19, # 1, p. 102 - 121
[3] European Journal of Organic Chemistry, 2013, # 3, p. 541 - 549
[4] Tetrahedron Letters, 2005, vol. 46, # 6, p. 967 - 969
[5] Patent: US2007/231300, 2007, A1. Location in patent: Page/Page column 13-14

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

2,5-PYRIDINEDICARBOXYLIC ACID Methanol Oxalyl chloride Sodium bicarbonate Dichloromethane

Ethyl acetate Water

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Preparation Products

Methyl 6-(hydroxymethyl)nicotinate Pyridine-2,5-dicarbaldehyde METHYL 6-FORMYLNICOTINATE

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from DIMETHYL PYRIDINE-2,5-DICARBOXYLATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	Dimethyl-2,5-pyridinecarboxylate 881-86-7	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	Dimethyl 2,5-pyridinedicarboxylate 881-86-7	US $1.00 / kg	1kg	95%-99%	as request	Career Henan Chemical Co

Dimethyl-2,5-pyridinecarboxylate
881-86-7
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

Dimethyl 2,5-pyridinedicarboxylate
881-86-7
US $1.00 / kg
95%-99%
Career Henan Chemical Co

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Spectrum

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE(881-86-7)MS DIMETHYL PYRIDINE-2,5-DICARBOXYLATE(881-86-7)¹HNMR DIMETHYL PYRIDINE-2,5-DICARBOXYLATE(881-86-7)IR1 DIMETHYL PYRIDINE-2,5-DICARBOXYLATE(881-86-7)IR2

881-86-7(DIMETHYL PYRIDINE-2,5-DICARBOXYLATE)Related Search:

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METHYL 6-METHOXYCARBONYL NICOTINATE DIMETHYL PYRIDINE-2,5-DICARBOXYLATE DIMETHYL 2,5-PYRIDINEDICARBOXYLATE PYRIDINE-2,5-DICARBOXYLIC ACID DIMETHYL ESTER Dimethyl isocinchomeronate~Pyridine-2,5-dicarboxylic acid dimethyl ester dimethyl isocinchomeronate Dimethyl-2,5-pyridinecarboxylate 2,5-Pyridinedicarboxylic acid, 2,5-diMethyl ester DIMETHYL PYRIDINE-2,5-DICARBOXYLATE HYDROCHLORIDE Dimethyl pyridine-2,5-dicarboxylate, 98+% 2,5-Pyridinedicarboxylic acid dimethyl ester Dimethyl 2,5-pyridine dicarboxylate 97% 2,5-dimethyl pyridine-2,5-dicarboxylate Dimethyl pyridine-2,5-dicarboxylate 97% 2,5-pyridine-dimethyl dicarboxylate DIMETHYL PYRIDINE-2,5-DICARBOXYLATE ISO 9001：2015 REACH Dimethyl-2,5-Pyridine Dicarboxylic Acid Dimethy1-2.5-pyridineaarbanylate Acifluorfen Impurity 7 2,5-Bis(methoxycarbonyl)pyridine 881-86-7 Pyridines Heterocyclic Building Blocks C9 to C46 Building Blocks Pyridine series Esters Pyridines API intermediates Aromatics Heterocycles Intermediates