bumadizone
- CAS No.
- 3583-64-0
- Chemical Name:
- bumadizone
- Synonyms
- Bumadizon;bumadizone;IKCNUEPHJHLSPG-UHFFFAOYSA-N;N-(2-Carboxycaproyl)hydrazobenzene;(2RS)-2-[(1,2-Diphenyldiazanyl)carb;Phenylbutazone EP Impurity A (Bumadizone);Butylmalonic acid 1-(N,N'-diphenyl hydrazide);Butylmalonic acid mono(1,2-diphenylhydrazide);2-(N,N'-diphenylhydrazinecarbonyl)hexanoic acid;Butylpropanedioic acid 1-(1,2-diphenyl hydrazide)
- CBNumber:
- CB1904970
- Molecular Formula:
- C19H22N2O3
- Molecular Weight:
- 326.39
- MDL Number:
- MFCD00864288
- MOL File:
- 3583-64-0.mol
- MSDS File:
- SDS
| Melting point | 117-119℃ |
|---|---|
| Boiling point | 487.4±47.0 °C(Predicted) |
| Density | 1.227±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.69±0.21(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | ATD81G944M |
| ATC code | M01AB07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
bumadizone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B689640 | Bumadizon | 3583-64-0 | 100mg | $150 | 2021-12-16 | Buy |
| Usbiological | 162964 | Bumadizon | 3583-64-0 | 500mg | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010877 | BUMADIZONE 95.00% | 3583-64-0 | 5MG | $496.1 | 2021-12-16 | Buy |
bumadizone Chemical Properties,Uses,Production
Originator
Eumotol,Byk Gulden,W. Germany,1972
Uses
Bumadizon, is a non-steroidal anti-inflammatory (NSAID) drug.
Definition
ChEBI: A carbohydrazide obtained by formal condensation of one of the carboxy groups from butylmalonic acid with the hydrazino group of 1,2-diphenylhydrazine. Used (as its calcium semihydrate) for treatment of rheumatoid arthritis.
Manufacturing Process
(a) A solution of 22.4 grams of dicyclohexylcarbodiimide in 120 ml of absolute
tetrahydrofuran is added dropwise at 5°-10°C in an atmosphere of nitrogen to
a solution of 20 grams of n-butylmalonic acid monoethyl ester and 19.6 grams
of freshly recrystallized hydrazobenzene in 320 ml of anhydrous
tetrahydrofuran. The mixture is then stirred for 15 hr at 25°C in an
atmosphere of nitrogen, then the precipitated dicyclohexyl urea is filtered off
and the filtrate, after the addition of 3 drops of glacial acetic acid, is
evaporated to dryness in vacuo. The residue is dissolved in 1 liter of ether, the
ethereal solution is extracted twice with 2 N potassium bicarbonate solution
and twice with 2 N hydrochloric acid, whereupon it is washed with water until
the washing water is neutral. The ethereal solution is dried over sodium
sulfate and concentrated in vacuo. The residue is fractionally distilled under
high vacuum whereupon the ester is obtained as a yellow oil. BP 170°C at
0.05 torr vacuum. Crystals which melt at 63°-65°C are obtained from
cyclohexane.
(b) A suspension of 7.1 grams of the ester obtained according to (a) in 40 ml
of aqueous 0.5 N sodium hydroxide solution is refluxed for 24 hours in an
atmosphere of nitrogen. The solution is filtered and traces of hydrazobenzene
are removed by extraction with ether. The aqueous solution is made acid to Congo paper at 10°C with concentrated hydrochloric acid, the oil which
separates is dissolved in 40 ml of ethyl acetate, the ethyl acetate solution is
isolated, and washed neutral with water. The solution is then extracted twice
with 36 ml of 0.5 N sodium bicarbonate solution each time.
The separate extracts are made acid to Congo paper with concentr
brand name
Bumaflex;Rheumatol.
Therapeutic Function
Analgesic, Antipyretic, Antirheumatic
World Health Organization (WHO)
Bumadizone, a pyrazolone derivative with antiinflammatory, analgesic and antipyretic activity, was introduced in 1972 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
bumadizone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| EnciPharmatech Co., Ltd | 025-52714267-66 13813902930 | stephen_shengll@hotmail.com | China | 232 | 64 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9394 | 52 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10287 | 55 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4901 | 55 |