TAS 103
- CAS No.
- 174634-08-3
- Chemical Name:
- TAS 103
- Synonyms
- TAS 103;CS-1287;BMS-247615;TAS-103 HC1;TAS-103 base;TAS-103(salt);TA103(bms-247615);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one;7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-
- CBNumber:
- CB21321579
- Molecular Formula:
- C20H19N3O2
- Molecular Weight:
- 333.38
- MDL Number:
- MFCD26960891
- MOL File:
- 174634-08-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| TAS-103 98+% | CD31002974 | 5mg | $83 |
| TAS-103 98+% | CD31002974 | 10mg | $132 |
| TAS-103 98+% | CD31002974 | 50mg | $381 |
| TAS-103 98+% | CD31002974 | 100mg | $658 |
| TAS-103(BMS247615) >98% | DC7898 | 250mg | $1100 |
| Melting point | 216-217 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 589.5±50.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 7.88±0.20(Predicted) |
| FDA UNII | YVC96489QV |
TAS 103 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD31002974 | TAS-103 98+% | 174634-08-3 | 5mg | $83 | 2021-12-16 | Buy |
| Crysdot | CD31002974 | TAS-103 98+% | 174634-08-3 | 10mg | $132 | 2021-12-16 | Buy |
| Crysdot | CD31002974 | TAS-103 98+% | 174634-08-3 | 50mg | $381 | 2021-12-16 | Buy |
| Crysdot | CD31002974 | TAS-103 98+% | 174634-08-3 | 100mg | $658 | 2021-12-16 | Buy |
| DC Chemicals | DC7898 | TAS-103(BMS247615) >98% | 174634-08-3 | 250mg | $1100 | 2021-12-16 | Buy |
TAS 103 Chemical Properties,Uses,Production
Uses
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
Biological Activity
TAS-103 is a dual DNA topoisomerase I/II (topoisomerase I/II) inhibitor for cancer research.
in vivo
TAS-103 (30 mg/kg, iv) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.
target
| Topoisomerase I
| Topoisomerase II
|
IC 50
Topoisomerase I; Topoisomerase II
References
[1] Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II DOI:10.1016/s0006-2952(00)00402-0
[2] Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7. DOI:10.1248/bpb.25.1385
[3] Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94. Epu DOI:10.1124/mol.107.043307
TAS 103 Preparation Products And Raw materials
Raw materials
Preparation Products
TAS 103 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1844 | 58 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Shanghai BetterBioChem Co., Ltd. | +86-18017644823 | sales@betterbiochem.com | China | 325 | 58 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1788 | 58 |
| Supplier | Advantage |
|---|---|
| InvivoChem | 58 |
| Amadis Chemical Company Limited | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 55 |
| LETOPHARM LIMITED | 58 |
| SPIRO PHARMA | 55 |
| ShangHai Biochempartner Co.,Ltd | 62 |
| Medi-tech Bioscientific Co., Ltd. | 58 |
| Musechem | 60 |
| Shanghai BetterBioChem Co., Ltd. | 58 |
| Twochem Co.Ltd. | 58 |
