N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
- CAS No.
- 392721-37-8
- Chemical Name:
- N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
- Synonyms
- Fasentin;Fasentin NEW;Fasentin >=98% (HPLC);Fasentin - CAS 392721-37-8 - Calbiochem;N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide;Butanamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-;anti-angiogenic,glucose,factor,Glucose transporter,inhibit,phase,necrosis,tumor,Fasentin,transport,GLUT,Inhibitor,G0/G1,FAS
- CBNumber:
- CB21845028
- Molecular Formula:
- C11H9ClF3NO2
- Molecular Weight:
- 279.64
- MDL Number:
- MFCD01001285
- MOL File:
- 392721-37-8.mol
- MSDS File:
- SDS
Boiling point | 394.2±42.0 °C(Predicted) |
---|---|
Density | 1.411±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | DMSO: >10mg/mL |
form | powder |
pka | 10.76±0.46(Predicted) |
color | white to off-white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F5557 | Fasentin ≥98% (HPLC) | 392721-37-8 | 5mg | $110 | 2024-03-01 | Buy |
Sigma-Aldrich | 341305 | Fasentin | 392721-37-8 | 25mg | $280 | 2024-03-01 | Buy |
Cayman Chemical | 27050 | Fasentin | 392721-37-8 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 27050 | Fasentin | 392721-37-8 | 5mg | $100 | 2024-03-01 | Buy |
Sigma-Aldrich | F5557 | Fasentin ≥98% (HPLC) | 392721-37-8 | 25mg | $419 | 2024-03-01 | Buy |
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide Chemical Properties,Uses,Production
Description
Fasentin (392721-37-8) is a novel inhibitor of glucose uptake which acts via inhibition of the glucose transporter GluT1 and GluT4 (IC50=68 μM).1?Inhibition of glucose uptake is cell type specific2?and is a promising approach to new cancer therapeutics3. Rescues cardiac progenitor cell dysfunction and mitochondrial fission induced by high glucose.4?Sensitizes cells to FAS-induced cell death.5,6
Uses
Fasentin is a novel glucose transport inhibitor that blocks glucose uptake and is also a chemical sensitizer to the death receptor stimuli FAS and tumor necrosis factor apoptosis-inducing ligand.
Uses
Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines and to study its effects on cytotoxic drugs induced by hydrocortisone (HC).
Biochem/physiol Actions
Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.
storage
Store at -20°C
References
1) Granchi?et al.?(2016),?Anticancer agents interacting with membrane glucose transporters; Med. Chem. Comm.,?7?1716 2) Kraus?et al. (2018),?Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell. Oncol. (Dordr),?41?485 3) Adekola?et al. (2012),?Glucose transporters in cancer metabolism; Curr. Opin. Oncol.,?24?650 4) Choi?et al.?(2016),?High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker; Prog. Biomol. Ther. (Seoul),?24?363 5) Schimmer?et al.?(2006),?Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors; Cancer Res.,?66?2367 6) Wood?et al.?(2008),?A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death; Mol. Cancer Ther.,?7?3546
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9082 | 58 |
Rhawn Reagent | 400-400-1332688 18019345275 | amy@rhawn.cn | China | 15503 | 58 |