网站主页 >> CAS数据库列表 >> N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
|
|
|
- CAS号:
- 392721-37-8
- 英文名:
- N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
- 英文别名:
- Fasentin;Fasentin NEW;Fasentin >=98% (HPLC);Fasentin - CAS 392721-37-8 - Calbiochem;N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide;Butanamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-;anti-angiogenic,glucose,factor,Glucose transporter,inhibit,phase,necrosis,tumor,Fasentin,transport,GLUT,Inhibitor,G0/G1,FAS
- 中文名:
- N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
- 中文别名:
- 化合物FASENTIN;FASENTIN,GLUT1 / GLUT4抑制剂;N-(4-氯-3-(三氟甲基)苯基)-3-氧代丁酰胺
- CBNumber:
- CB21845028
- 分子式:
- C11H9ClF3NO2
- 分子量:
- 279.64
- MOL File:
- 392721-37-8.mol
|
|
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide化学性质
-
沸点:
-
394.2±42.0 °C(Predicted)
-
|
-
密度:
-
1.411±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
room temp
-
|
-
溶解度:
-
DMSO: >10mg/mL
-
|
-
形态:
-
powder
-
|
-
酸度系数(pKa):
-
10.76±0.46(Predicted)
-
|
-
颜色:
-
white to off-white
-
|
-
稳定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
-
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide性质、用途与生产工艺
Fasentin 是有效的葡萄糖摄取抑制剂，可抑制 GLUT-1/GLUT-4 转运蛋白。Fasentin 优先抑制 GLUT4 (IC50=68 μM)。Fasentin 是死亡受体刺激 (FAS) 敏化剂，可敏化细胞对 FAS 诱导的细胞死亡。Fasentin 也是诱导肿瘤坏死因子 (TNF) 凋亡配体的敏化剂。Fasentin 阻断癌细胞系中的葡萄糖摄取，并具有抗血管生成活性。
|
GLUT4
68 μM (IC
50
)
|
GLUT1
|
Fasentin (0.1-1000 μM; 72 hours) inhibits endothelial, tumour and fibroblast cell growth without inducing cell death.
Fasentin (25-100 μM; 16-24 hours) induces a cell cycle arrest in G0/G1 phase and reduces the cell number in S phase in a dose-dependent manner.
Fasentin (50 μM; 16 hours) alters expression of genes associated with glucose deprivation such as AspSyn and PCK-2.
Fasentin (15, 30, 80 μM; pretreatment 1 hour) induces glucose deprivation, partially blocks glucose uptake in PPC-1, DU145, and U937 cells.
Fasentin (100 μM; 16 hours) does not affect the migratory capability of endothelial cells.
Fasentin (25-100 μM; 16 hours) lowers levels of phospho-ERK in HMECs, indicating a partial inhibition on the ERK signalling pathway, even though the effect is not statistically significant. Fasentin does not inhibit the tyrosine kinase activity of VEGFR2.
Fasentin interacts with a unique site in the intracellular channel of GLUT1.
Cell Viability Assay
|
Cell Line:
|
Three types of endothelial cells ECs (HMEC, human microvascular endothelial cells; HUVEC, human umbilical vein endothelial cells; and BAEC, bovine aortic endothelial cells), three human tumour cell lines (MDA-MB-231 and MCF7 breast carcinoma cells, and HeLa cervix adenocarcinoma cells), and human gingival fibroblasts (HGF)
|
|
Concentration:
|
0.1, 1, 10, 100, 1000 μM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Inhibited endothelial, tumour and fibroblast cell growth (IC
50
=26.3-111.2 μM) without inducing cell death.
|
Cell Cycle Analysis
|
Cell Line:
|
HMECs
|
|
Concentration:
|
25, 50, 100 μM
|
|
Incubation Time:
|
16, 24 hours
|
|
Result:
|
Induced a cell cycle arrest in G0/G1 phase and reduced the cell number in S phase in a dose-dependent manner.
Did not increase the subG1 population.
|
RT-PCR
|
Cell Line:
|
PPC-1 cells
[2]
|
|
Concentration:
|
50 μM
|
|
Incubation Time:
|
16 hours
|
|
Result:
|
Altered expression of genes associated with glucose deprivation such as AspSyn and PCK-2 not FLIP mRNA expression.
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101849 | N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
Fasentin | 392721-37-8 | 5mg | 700元 |
| 2024/01/25 | HY-101849 | N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
Fasentin | 392721-37-8 | 10mM * 1mLin DMSO | 770元 |
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
生产厂家
392721-37-8, N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide 相关搜索:
ZM447439 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-八氢-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-3-丙酸叔丁酯 LFM-A13 AAL-993 N-1
- 配体家族
- FASENTIN,GLUT1 / GLUT4抑制剂
- 化合物FASENTIN
- N-(4-氯-3-(三氟甲基)苯基)-3-氧代丁酰胺
- 392721-37-8
- Butanamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-
- anti-angiogenic,glucose,factor,Glucose transporter,inhibit,phase,necrosis,tumor,Fasentin,transport,GLUT,Inhibitor,G0/G1,FAS
- Fasentin >=98% (HPLC)
- Fasentin NEW
- Fasentin - CAS 392721-37-8 - Calbiochem
- Fasentin
- N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide