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(S)-(-)-Nicoumalone

(S)-(-)-Nicoumalone Structure
(S)-(-)-Nicoumalone structure
CAS No.
66556-78-3
Chemical Name:
(S)-(-)-Nicoumalone
Synonyms
(S)-(-)-Nicoumalone;Acenocoumarol Impurity 2（Acenocoumarol (S)-Isomer);2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-1-(4-nitrophenyl)-3-oxobutyl]-
CBNumber:
CB22129552
Molecular Formula:
C19H15NO6
Molecular Weight:
353.328
MDL Number:
MFCD00869569
MOL File:
66556-78-3.mol
Last updated:2023-06-08 09:03:09
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(S)-(-)-Nicoumalone Properties

Boiling point 592.7±50.0 °C(Predicted)
Density 1.427±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.2 mg/ml
form A crystalline solid
pka 4.50±1.00(Predicted)
FDA UNII 4O90VF03HV

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P202-P280-P308+P313-P405-P501

(S)-(-)-Nicoumalone price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9000336 (S)-Acenocoumarol ≥98% 66556-78-3 1mg $135 2024-03-01 Buy
Cayman Chemical 9000336 (S)-Acenocoumarol ≥98% 66556-78-3 5mg $601 2024-03-01 Buy
Cayman Chemical 9000336 (S)-Acenocoumarol ≥98% 66556-78-3 10mg $1068 2024-03-01 Buy
TRC A130795 (S)-Acenocoumarol 66556-78-3 10mg $1230 2021-12-16 Buy
AK Scientific 1097AH (S)-Acenocoumarol 66556-78-3 10mg $1288 2021-12-16 Buy
Product number Packaging Price Buy
9000336 1mg $135 Buy
9000336 5mg $601 Buy
9000336 10mg $1068 Buy
A130795 10mg $1230 Buy
1097AH 10mg $1288 Buy

(S)-(-)-Nicoumalone Chemical Properties,Uses,Production

Description

Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The S-enantiomer undergoes extensive first-pass metabolism during absorption from the gastrointestinal tract, whereas (R)-acenocoumarol is rapidly absorbed and provides essentially complete oral bioavailability. Perhaps related to these pharmacokinetic characteristics, (S)-acenocoumarol is less potent in vivo as an anti-coagulant than the (R)-enantiomer. As the clearance of acenocoumarol is ~20-fold faster than that for warfarin, the plasma concentrations of acenocoumarol are substantially lower than those for warfarin in patients receiving long-term treatment.

Uses

S-Enantiomer of

Definition

ChEBI: The (R)-enantiomer of acenocoumarol.

(S)-(-)-Nicoumalone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(-)-Nicoumalone Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Cato Research Chemicals Inc. 020-81960175 min.he@cato-chem.com China 1958 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Beijing Minruida Technology Co., Ltd. 010-82387566 18001021521; sales@mreda.com.cn China 21450 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55791 58
BOC Sciences -- info@bocsci.com USA 0 65
Jinan blalong chemical co. LTD 2710913286@.com 1513643261@qq.com China 14253 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky (shanghai) International Co.,Ltd 60
Cato Research Chemicals Inc. 55
Shanghai Hongye Biotechnology Co. Ltd 58
Beijing Minruida Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
BOC Sciences 65
Jinan blalong chemical co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
(S)-(-)-Nicoumalone Acenocoumarol Impurity 2（Acenocoumarol (S)-Isomer) 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-1-(4-nitrophenyl)-3-oxobutyl]- 66556-78-3 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals