ChemicalBook >> CAS DataBase List >>1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether


Chemical Name:
1,1,2,2-TETRAFLUOROETHYL 2,2,3,3-TETRAFLUOROPROPYL ETHER;1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane;uoropropyL;DAIKIN T-5216;HFE458 HFE-458;1,1,2,2-TetrafL;2,2,3,3-tetrafL;HYDROFLUOROETHER-458;2-Tetrafluoroethyl-2;3-tetrafluoropropylether
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Modify Date:2022-08-26 03:05:28

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Properties

Boiling point 92 °C
Density 1.533
refractive index 1.29
Flash point 27.5 °C
storage temp. Sealed in dry,Room Temperature
Specific Gravity 1.533
CAS DataBase Reference 16627-68-2(CAS DataBase Reference)
EPA Substance Registry System (2H-Perfluoroethyl)(1H,1H,3H-perfluoropropyl)ether (16627-68-2)


Risk and Safety Statements

Signal word  Warning
Hazard statements  H226
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3271
HazardClass  IRRITANT
PackingGroup  II
HS Code  29091990

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3069 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether >98.0%(GC) 16627-68-2 5g $21 2022-04-27 Buy
TCI Chemical T3069 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether >98.0%(GC) 16627-68-2 25g $54 2022-04-27 Buy
Frontier Specialty Chemicals JK246778 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether 16627-68-2 5g $68 2021-12-16 Buy
Oakwood 010635 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether 16627-68-2 100g $75 2021-12-16 Buy
AK Scientific 5332AD 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether 16627-68-2 25g $79 2021-12-16 Buy
Product number Packaging Price Buy
T3069 5g $21 Buy
T3069 25g $54 Buy
JK246778 5g $68 Buy
010635 100g $75 Buy
5332AD 25g $79 Buy

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Chemical Properties,Uses,Production


1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (HFE-458) is a hydrofluoroether. Hydrofluoroether is a new type of Chemicalbook chlorofluorocarbons (CFCs) substitute, ODP is zero, GWP is low, and the atmospheric residence time is very short. It is considered as one of the ideal substitutes for CFCs.


1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.


A system of a 6-L autoclave made of stainless steel was evacuated. The autoclave was charged with 401 g of potassium hydroxide (7.15 mol, 0.55 molar amount relative to 1 mol of a fluorine-containing alkyl alcohol), water (1604 mL), 2,2,3,3-tetrafluoro-1-propanol (boiling point of 109° C., specific gravity of 1.4) represented by HCF2CF2CH2OH (1716 g, 13 mol) as a fluorine-containing alkyl alcohol. Then, the system was evacuated and replaced with nitrogen 20 times at room temperature. After evacuated, the system was filled with tetrafluoroethylene to 0.1 MPa, and the reaction system was heated to 85° C. After the temperature in the system reached 85° C., tetrafluoroethylene was added thereto little by little so that the reaction pressure was kept at 0.5 to 0.8 MPa. The temperature in the system was adjusted so as to be kept at 75 to 95° C.Tetrafluoroethylene was added until the amount reached 0.5 molar relative to 1 mol of the fluorine-containing alkyl alcohol. The reaction was continuously carried out under stirring. When reduction in the pressure in the autoclave was stopped, the temperature in the autoclave was reduced to room temperature and unreacted tetrafluoroethylene was discharged, and the reaction was stopped. These steps took 5 hours to perform.The fluoroether of a lower phase of the production solution was HCF2CF2CH2OCF2CF2H (boiling point of 92° C., specific gravity of 1.52). Table 1 shows the composition of the fluoroether production solution of a lower phase resulting from GC analysis.

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 137)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9404 55
CD Chemical Group Limited
+86-13651442114 +86-13651442114 China 20374 58
henan kanbei chemical co.,ltd
+86-15237804566 +86-15237804566 China 500 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 22021 55
career henan chemical co
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Hubei xin bonus chemical co. LTD
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0371-55170695 CHINA 26742 58
+8618523575427 China 47501 58
+8613917686115 CHINA 704 58

View Lastest Price from 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-09-20 HFE-458 /1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether
US $0.00 / kg 1kg 99% 1000kg henan kanbei chemical co.,ltd
2019-07-06 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether
US $1.00 / kg 1kg 95%-99% 100kg Career Henan Chemical Co
2,2,3,3-TETRAFLUORO-1-(1,1,2,2-TETRAFLUOROETHOXY)PROPANE 1,1,2,2,5,5,6,6-OCTAFLUORO-3-OXAHEXANE product NaMe 2,2,3,3-Tetrafluoro-1-(1,1,2,2-tetrafluoroethoxy)propane 1,1,2,2,5,5,6,6-Octafluoro-3-oxahexane, 1,1,2,2-Tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane 2H-Tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether HYDROFLUOROETHER(HFE-458) DAIKIN T-5216 Propane,1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)- 2H-Tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether 98% HYDROFLUOROETHER-458 HFE-458 /1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether 1,1,2,2-TetrafL 2,2,3,3-tetrafL uoropropyL 1,1,2,2-Tetrafluoroethyl-2,2,3,3-Tetrafluoropropylether,>98% 2-Tetrafluoroethyl-2 3-tetrafluoropropylether HFE458 HFE-458 1,1,2,2-TETRAFLUOROETHYL 2,2,3,3-TETRAFLUOROPROPYL ETHER 1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane 16627-68-2