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ChemicalBook >> CAS DataBase List >>N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Structure
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide structure
CAS No.
925434-55-5
Chemical Name:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Synonyms
SRT1720 free base/ STR1720 HCl salt;SRT1720 - CAS 925434-55-5 - Calbiochem;N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide;N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide;2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-;N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
CBNumber:
CB22489951
Molecular Formula:
C25H23N7OS
Molecular Weight:
469.56
MDL Number:
MFCD14584468
MOL File:
925434-55-5.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Properties

Melting point 221℃
Density 1.46
storage temp. -20C
solubility DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM)
form Yellow solid
pka 11.19±0.70(Predicted)
FDA UNII DX3FHY76FZ

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 567860 SRT1720 - CAS 925434-55-5 - Calbiochem
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). 		925434-55-5 10mg $245 2024-03-01 Buy
Biosynth Carbosynth FP41292 SRT 1720 925434-55-5 50mg $250 2021-12-16 Buy
AK Scientific 5644AC N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide 925434-55-5 25mg $303 2021-12-16 Buy
Biosynth Carbosynth FP41292 SRT 1720 925434-55-5 100mg $350 2021-12-16 Buy
AK Scientific 5644AC N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide 925434-55-5 50mg $387 2021-12-16 Buy
Product number Packaging Price Buy
567860 10mg $245 Buy
FP41292 50mg $250 Buy
5644AC 25mg $303 Buy
FP41292 100mg $350 Buy
5644AC 50mg $387 Buy

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Chemical Properties,Uses,Production

General Description

A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).

storage

Store at -20°C

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide synthesis

6851-99-6
925434-55-5
Synthesis of N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide from 2-Bromo-2'-nitroacetophenone

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Preparation Products And Raw materials

Raw materials

tert-butyl 4-((6-(2-aMinophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl)piperazine-1-carboxylate 6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID (6-(2-nitrophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl Methanesulfonate 6-(2-NITRO-PHENYL)-IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE
2-QUINOXALINECARBONYL CHLORIDE 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-Bromo-2'-nitroacetophenone

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Preparation Products

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
RR Scientific LLC 		+86-13917743231 sales@rrscientific.com United States 878 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9440 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
InvivoChem 		58
RR Scientific LLC 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
Shanghai Chaolan Chemical Technology Center 58

View Lastest Price from N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide pictures 2020-02-19 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
925434-55-5
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

925434-55-5(N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide)Related Search:

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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide 2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]- SRT1720 free base/ STR1720 HCl salt Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide SRT1720 - CAS 925434-55-5 - Calbiochem N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide 925434-55-5 C25H23N7OS