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Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate structure

CAS No.: 323176-93-8

Chemical Name:: Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate

Synonyms: Venlafaxine IMpurity B;Venlafaxine EP IMpurity B;Venlafaxine EP Impurity B HCl;Ethyl (2RS)-3-(Dimethylamino)-2-(4-;ethyl 3-(dimethylamino)-2-(4-methoxyphenyl);ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Ethyl 3-Dimethylamino-2-(4-methoxy-phenyl)-propionate;Venlafaxine EP Impurity B (Venlafaxine Ester Impurity)

CBNumber:: CB22508656

Molecular Formula:: C14H21NO3

Molecular Weight:: 251.32

MDL Number:: MFCD16293840

MOL File:: 323176-93-8.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Properties

Boiling point	337.9±42.0 °C(Predicted)
Density	1.045±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Oil
pka	8.61±0.28(Predicted)
color	Pale Brown to Light Brown
FDA UNII	20A3002JTT

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	E925055	Ethylα-(p-Methoxyphenyl)-β-(dimethylamino)propionate	323176-93-8	50mg	$185	2021-12-16	Buy
AK Scientific	7161CS	Ethylalpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate	323176-93-8	250mg	$399	2021-12-16	Buy
AK Scientific	7161CS	Ethylalpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate	323176-93-8	500mg	$671	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0293941	ALPHA-[(DIMETHYLAMINO)METHYL]-4-METHOXYBENZENEACETIC ACID ETHYL ESTER 95.00%	323176-93-8	100MG	$704.55	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0293941	ALPHA-[(DIMETHYLAMINO)METHYL]-4-METHOXYBENZENEACETIC ACID ETHYL ESTER 95.00%	323176-93-8	1G	$1593.9	2021-12-16	Buy

Product number	Packaging	Price	Buy
E925055	50mg	$185	Buy
7161CS	250mg	$399	Buy
7161CS	500mg	$671	Buy
CHM0293941	100MG	$704.55	Buy
CHM0293941	1G	$1593.9	Buy

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Chemical Properties,Uses,Production

Synthesis

A mixture of ethyl p-methoxyphenylacetate (4 g, 20.62 mmol), paraformaldehyde (1.05 g, 35.0 mmol) and TBAI (0.381 g, 1.03 mmol) was heated in PhMe (16 ml) at 80-85 ºC for 3.5 hours. The reaction mixture was allowed to cool. Then, a solution of Me2NH in THF was added to the reaction mixture at 0 ºC in the presence of catalytic FeCl3 (0.160 g, 0.001 mol) and stirred for 45 minutes. After completion of the reaction, 100 ml water was added to the reaction mixture and aqueous layer was acidified with conc. HCl (pH = 2). Aqueous layer was washed with DCM (3x 50 ml) and made alkaline (pH = 8) using 5% NaOH solution, extracted with DCM (3x 50 ml), washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Column chromatographic purification over silca gel (0.5% MeOH in CHCl3) furnished aminoester 65 as a thick colourless oil (3.08 g). When the reaction was carried out without catalyst, it took 48 hours for completetion.

Uses

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate (Venlafaxine EP Impurity B) is an impurity of Venlafaxine (impurity B).

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Suppliers

Global( 62)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Adamas Reagent, Ltd.	400-6009262 16621234537	zhangsn@titansci.com	China	14113	59

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
Career Henan Chemica Co	58
ANHUI WITOP BIOTECH CO., LTD	58
sgtlifesciences pvt ltd	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
Adamas Reagent, Ltd.	59

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Spectrum

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate(323176-93-8)¹HNMR Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate(323176-93-8)¹³CNMR

323176-93-8(Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate)Related Search:

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Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Ethyl (2RS)-3-(DiMethylaMino)-2-(4-Methoxyphenyl)propanoate Hydrochloride Venlafaxine EP Impurity B HCl ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate α-[(DiMethylaMino)Methyl]-4-Methoxybenzeneacetic Acid Ethyl Ester Venlafaxine EP IMpurity B Venlafaxine IMpurity B D,L N,O-Didesmethylvenlafaxine (Venlafaxine Impurity B) ethyl 3-(dimethylamino)-2-(4-methoxyphenyl) Venlafaxine impurity 2/Venlafaxine EP Impurity B HCl/Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate hydrochloride Ethyl (2RS)-3-(Dimethylamino)-2-(4- Benzeneacetic acid, α-[(dimethylamino)methyl]-4-methoxy-, ethyl ester Venlafaxine EP Impurity B (Venlafaxine Ester Impurity) Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate (Venlafaxine Impurity) Ethyl 3-Dimethylamino-2-(4-methoxy-phenyl)-propionate 323176-93-8 Intermediates & Fine Chemicals Pharmaceuticals Aromatics Impurities